摘要
目的分析变应性鼻炎(AR)在全国和广东省流行特征的差异,以及经济发展水平对尘螨过敏阳性率的影响。方法通过我国访问量最大的搜索引擎百度提供的'百度指数',选取2014~2018年共5年'过敏性鼻炎'搜索走势,分析全国范围和广东省AR搜索走势差异并分析其特征;通过对比'过敏性鼻炎'和'螨虫'在全国和广东省搜索走势,分析两组数据的相关性;搜集广东省11个地市15所三甲医院临床诊断A R患者尘螨标准化过敏原皮肤点刺(SPT)阳性率,与当地人均国内生产总值(gross domestic product,GDP)对比,分析其相关性。结果全国AR搜索走势具有明显的季节差异,每年4~5月及8~9月为搜索高峰,广东省AR搜索走势没有明显季节差异,只有1~2月搜索量较低;全国每年AR日搜索量谷峰比为24.37%,而广东省为42.28%,两者相比具有显著差异(P<0.001),全国月均搜索量大于峰值月份50%的月份数每年平均为6个月,而广东省平均每年为10.8个月,两者相比具有显著性差异(P=0.008);截取每月1日'过敏性鼻炎'与'螨虫'搜索量进行相关性分析,全国范围内两者没有相关性(R_s=0.392,P=0.064),而广东省两者搜索量具有明显相关性(R=0.604,P=0.002);广东省各地市多中心临床诊断AR患者尘螨SPT阳性率与当地人均GDP具有显著的相关性(R_s=0.900,P<0.001)。结论网络搜索大数据可在一定程度上反映真实世界AR的流行情况,通过对百度指数搜索走势分析,全国AR发作以季节性为主,而广东省AR发作以常年性为主,'螨虫'是广东省AR患者最为关注的过敏原,广东省各地市AR患者尘螨SPT阳性率与当地人均GDP呈高度相关,表明在气候条件基本一致的条件下,经济发展水平差异以及由此带来的生活方式改变是尘螨过敏率增高的重要原因。
OBJECTIVE Analyzing the difference of epidemiology of AR between China and Guangdong province,and asking whether social developing level affecting the incidence of AR.METHODS Baidu is the largest searching engine in China,which providing the‘Baidu index’that showing search volume(SV)of specific queries.We investigated the SV of AR by Baidu index from 2014 to 2018,found the difference of AR SV between China and Guangdong province.Further,we analyzed the correlation between SV of AR and SV of dust mite,and the correlation between dust mite SPT positive rate and per capita GDP of the cities in Guangdong province.RESULTS SV of AR in China had significant seasonal diversity,the first peak from April to May and the second peak from August to September,whereas SV of AR in Guangdong province did not show seasonal diversity.In each year,the mean valley-peak ratios of single day SV in China and Guangdong province were 24.37%and 42.28%respectively,which had significant difference(P<0.001).There was 6 and 10.8 months in China and Guangdong province that mean monthly SV over 50%of the peak monthly SV respectively,and showed significant difference(P=0.008).Negative correlation was found between SV of AR and SV of dust mite in China(R_s=0.392,P=0.064)but positive Guangdong province(R=0.604,P=0.002).In different cities of Guangdong province,the positive rate of dust mite SPT in AR patients was strongly correlated with per capita GDP(R_s=0.900,P<0.001).CONCLUSION SV might reflect AR incidence in the real world.By investigating Baidu index,we found AR was seasonal in China but perennial in Guangdong province which in southern China.Dust mite was the most concerning allergen by AR patients in Guangdong province.In the similar climate situation,per capita GDP was strongly correlated with dust mite SPT positive rate,indicated that economic developing level and changing of living style are the important reason of dust mite allergy.
作者
黄健聪
王玮豪
洪海裕
杨贵
苗北平
蔡伟伟
吴国谦
刘文林
吕颜路
刘雪婷
李峰
王凯
徐春来
张志雄
卢汉桂
廖艳萍
邱惠军
杨钦泰
HUANG Jiancong;WANG Weihao;HONG Haiyu;YANGGui;MIAO Beiping;CAI Weiwei;WU Guoqian;LIUWenlin;LYU Yanlu;LIU Xueting;LI Feng;WANG Kai;XU Chunlai;ZHANG Zhixiong;LU Hangui;LIAOYanping;QIU Huijun;YANG Qintai(Department of Otolaryngology Head and Neck Surgery,the Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,Guangdong,510630,China;Departmentof Otolaryngology,the Fifth Affiliated Hospital of SunYat-sen University,Zhuhai,Guangdong,519000,China;Otolaryngology Hospital of Shenzhen LonggangCentral Hospital,Shenzhen,Guangdong,518172,China;Depar tment of Otolaryngology,Shenzhen SecondPeople's Hospital,Shenzhen,Guangdong,518035,China;Department of Otolaryngology,Guangzhou PanyuCentral Hospital,Guangzhou,Guangdong,511400,China;Department of Otolaryngology,Dongguan People'sHospital,Dongguan,Guangdong,523059,China;Department of Otolaryngology,Qingyuan People's Hospital,Qingyuan,Guangdong,511500,China;Departmentof Otolaryngology,Shenzhen First People's Hospital,Shenzhen,Guangdong,518020,China;Department ofOtolaryngology,Second Affiliated Hospital of GuangzhouMedical University,Guangzhou,Guangdong,510260,China;Department of Otolaryngology,Zhanjiang CentralPeople's Hospital,Zhanjiang,Guangdong,524045,China;Department of Otolaryngology,Foshan First People'sHospital,Foshan,Guangdong,528000,China;Departmentof Otolaryngology,Heyuan People's Hospital,Heyuan,Guangdong,517000,China;Department of Otolaryngology,Meizhou People's Hospital,Meizhou,Guangdong,514031,China;Department of Otolaryngology,Shantou CentralHospital,Shantou,Guangdong,515031,China;Departmentof Otolaryngology,Huizhou Central People's Hospital,Huizhou,Guangdong,516001,China)
出处
《中国耳鼻咽喉头颈外科》
CSCD
2019年第8期399-404,共6页
Chinese Archives of Otolaryngology-Head and Neck Surgery
基金
国家自然科学基金(81870704、81670912)
广州市产学研重大(对外合作)项目(201704030046)
关键词
鼻炎
变应性
常年性
鼻炎
变应性
季节性
尘蟎科
抗原
尘螨属
国内生产总值
网络搜索指数
Rhinitis,Allergic,Perennial
Rhinitis,Allergic,Seasonal
Pyroglyphidae
Antigens,Dermatophagoides
Gross Domestic Product
internet search volume
