摘要
目的制备羧甲基化白及多糖-壳聚糖载姜黄素聚电解质复合膜,进行处方、制备工艺优化,并进行质量评价。方法对白及多糖进行羧甲基化修饰,羧甲基化白及多糖与壳聚糖通过静电结合形成水不溶性复合物。以姜黄素为模型药物,采用溶剂挥发法制备载药聚电解质复合膜;通过单因素和正交设计法进行处方优化,用扫描电子显微镜和显微红外光谱对复合膜的形态和结构进行表征。结果最优处方为羧甲基白及多糖117 mg,壳聚糖233 mg,甘油含量为25%,姜黄素为20 mg。平均厚度为(74.0±2.0)μm,载药量为95.41%,体外累积释放率可达93.78%。结论优化条件下制备的载药复合膜外观光滑平整,分布均匀,载药量和累积释放度良好。
Objective To prepare carboxymethyl Bletilla striata polysaccharide-chitosan@curcumin(CM-BSP) polyelectrolyte complex films, optimize their preparation technology, and evaluate its quality. Methods CM-BSP was synthesized, then CM-BSP and CS formed water-insoluble complex by electrostatic bonding, the Cur-loaded polyelectrolyte complex films were prepared by a volatilization of solvent method. The formulation and preparation technology were optimized using an orthogonal design method and the morphology and structure were observed by scanning electron microscopy and fourier transform microscopic infrared spectroscopy. Results The optimal prescription was of CM-BSP 117 mg, CS 233 mg, glycerol 25%, Cur 20 mg. The mean thickness of Cur-loaded polyelectrolyte complex films was(74.0 ± 2.0) μm, drug loading capacities was 95.41%, and in vitro release rate was 93.78%. Conclusion The obtained polyelectrolyte complex films displayed an smooth exterior inspection, uniform distribution, good drug loading capacities and in vitro release rate.
作者
王玉蓉
冯斌
巨佳
成黎霏
王济
顾宜
王晓娟
WANG Yu-rong;FENG Bin;JU Jia;CHENG Li-fei;WANG Ji;GU Yi;WANG Xiao-juan(Shaanxi University of Chinese Medicine,Xianyang 712046,China;State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture,Department of Pharmacy,Hospital of Stomatology,The Fourth Military Medical University,Xi’an 710032,China)
出处
《中草药》
CAS
CSCD
北大核心
2020年第4期978-985,共8页
Chinese Traditional and Herbal Drugs
基金
陕西省中医管理局中医药科研课题(JCMS053)。
关键词
羧甲基化
白及多糖
壳聚糖
姜黄素
聚电解质复合膜
处方优化
质量评价
溶剂挥发法
正交设计
carboxymethylation
Bletilla striata polysaccharide
chitosan
curcumin
polyelectrolyte complex films
formulation optimization
quality evaluation
solvent evaporation method
orthogonal design
作者简介
王玉蓉(1994—),女,硕士研究生,研究方向为中药药剂学。Tel:(029)84773998,E-mail:2995296639@qq.com;通信作者:王晓娟(1962—),女,主任药师,研究方向为天然药物化学与中药新制剂。Tel:(029)84773189,E-mail:wxjyh@fmmu.edu.cn。
