摘要
目的探讨黄连总生物碱治疗外阴阴道假丝酵母菌病(VVC)的疗效及对阴道微生态的影响。方法选取VVC非妊娠期患者101例,按照随机数表法分为观察组(50例)和对照组(51例),观察组使用黄连总生物碱阴道栓,对照组使用克霉唑阴道片,观察两种药物对VVC临床效果及对阴道微生态影响。结果观察组治愈率为83.67%,总有效率96.00%,对照组治愈率为86.00%,总有效率96.00为%,两组差异无统计学意义(P>0.05),治疗后观察组乳杆菌分级正常所占比例显著高于对照组(P<0.05),两组VVC症状评分、分群密集度与多样性差异均无统计学意义。结论黄连总生物碱治疗VVC的临床疗效基本等同于克霉唑,在乳杆菌分级方面优于克霉唑。
Objective To investigate the efficacy and safety of total alkaloids of Coptis chinensis in the treatment of vulvovaginal candidiasis(VVC). Methods A total of 101 cases of VVC in non-pregnant period were selected and divided into observation group(50 cases) or control group(51 cases) according to random number table. The observation group was treated with total alkaloids of Coptis chinensis vaginal suppository while the control group was treated with clotrimazole vaginal tablets. The clinical effects in the two drugs were observed and compared. Results The cure rate in the observation group was 83.67% and the total efficiency rate was 95.90%, while the cure rate in the control group was 86.00%, and the total efficiency rate was 96.00%. There was no significant difference between the two groups(P>0.05). After treatment, the proportion of normal grading of Lactobacillus in the observation group was significantly higher than that in the control group(P<0.05). Conclusion There was no significant difference in VVC symptom score, clustering density and diversity between the two groups.
作者
陈怡琼
宁玉梅
周晓涵
汪强
杨懿
刘杰
沈晓芳
祝秀芝
CHEN Yiqiong;NING Yumei;ZHOU Xiaohan;WANG Qiang;YANG Yi;LIU Jie;SHEN Xiaofang;ZHU Xiuzhi(The Second Clinical Medical College of Zhejiang Chinese Medical University,Hangzhou,Zhejiang310053,China;不详)
出处
《中国微生态学杂志》
CAS
CSCD
2020年第2期219-223,共5页
Chinese Journal of Microecology
基金
浙江省中医药科技计划(2017ZQ015).
作者简介
陈怡琼(1994-),女,硕士,从事女性生殖道感染性疾病研究,E-mail:775247223@qq.com;通信作者:祝秀芝(1983-),女,硕士,从事女性生殖道感染性疾病研究,E-mail:82695560@qq.com
