Background Though type 2 diabetes mellitus(T2DM)is an important and independent risk factor for coronary artery disease(CAD)in general population,whether this feature also exists in patients with familial hypercholest...Background Though type 2 diabetes mellitus(T2DM)is an important and independent risk factor for coronary artery disease(CAD)in general population,whether this feature also exists in patients with familial hypercholesterolemia(FH)is less determined.The current study aims to characterize the clinical,laboratory,coronary and genetic characteristics of the FH patients with T2DM compared with FH alone.展开更多
Objective Vascular endothelial cells senescence is one of major risk factors for atherosclerotic diseases,which can be induced by endogenous peptides,such as angiotensin Ⅱ(Ang Ⅱ).However,the effect of chronic Ang Ⅱ...Objective Vascular endothelial cells senescence is one of major risk factors for atherosclerotic diseases,which can be induced by endogenous peptides,such as angiotensin Ⅱ(Ang Ⅱ).However,the effect of chronic Ang Ⅱ stimulation on endothelial senescence remains unknown.Therefore,this study aims to investigate the changes in morphology and function of human umbilical vein endothelial cells(HUVECs)in response to the chronic stimulation of Ang Ⅱ.展开更多
Objective To establish three-dimensional phenotyping system for congenital heart disease in mouse and to lay a foundation for the study of phenotype identification and mechanism of congenital heart disease.Methods Twe...Objective To establish three-dimensional phenotyping system for congenital heart disease in mouse and to lay a foundation for the study of phenotype identification and mechanism of congenital heart disease.Methods Twelve SPF C57BL/6 J wild type pregnant mice(8-10 week-old)were randomly divided into control group(n=6)and experimental group(n=6).展开更多
Background Cyanotic congenital heart disease(CCHD)is one ofthe most common birth anomaly,in which chronic hypoxia is the basic pathophysiological process.Researches in the protective mechanisms of cardiomyocytes to ch...Background Cyanotic congenital heart disease(CCHD)is one ofthe most common birth anomaly,in which chronic hypoxia is the basic pathophysiological process.Researches in the protective mechanisms of cardiomyocytes to chronic hypoxia have the potential to provide novel treatment strategies for many patients.Metabolomics is a study of metabolism at global level,which capture global biochemical events by assaying thousands of small molecules in tissues,followed by application of bioinformatics to define metabolomic signatures of the targets.In order to describe the features of metabolic remodeling of the heart of CCHD,we conducted our study on the effect of hypoxia on metabolism of human heart by using tissue from patients with CCHD compared with that from patients with non-cyanotic CHD(NCCHD).展开更多
Objective Calcium Voltage-Gated Channel Subunit Alpha1 C(CACNA1C)gene encodes an alpha-1 subunit of a voltage-dependent calcium channel.This subunit forms the pore through which calcium ions pass into the cell and pla...Objective Calcium Voltage-Gated Channel Subunit Alpha1 C(CACNA1C)gene encodes an alpha-1 subunit of a voltage-dependent calcium channel.This subunit forms the pore through which calcium ions pass into the cell and plays an important role in regulating blood pressure.Smoking habit has been proven become the risk factor of hypertension.This study aimed to investigate the interaction of variants in CACNA1C gene with smoke in blood pressure(BP)responses to dietary sodium and potassium intervention.展开更多
Background Relations of lipoprotein (a)(Lp[a]) and proprotein convertase substilisin/kexin type 9 (PCSK9) levels to coronary artery disease (CAD) have been well established in general population, while little is known...Background Relations of lipoprotein (a)(Lp[a]) and proprotein convertase substilisin/kexin type 9 (PCSK9) levels to coronary artery disease (CAD) have been well established in general population, while little is known about the association between Lp(a) or PCSK9 and atherosclerotic lesions of different artery sites in patients with familial hypercholesterolemia (FH).展开更多
Background Arrhythmogenic right ventricular cardiomyopathy(ARVC)is an inherited primary cardiomyopathy characterized by myocardial degeneration with fibro-fatty replacement.Clinical and genetic features of ARVC were w...Background Arrhythmogenic right ventricular cardiomyopathy(ARVC)is an inherited primary cardiomyopathy characterized by myocardial degeneration with fibro-fatty replacement.Clinical and genetic features of ARVC were well identified in Caucasian cohorts,but seldom examined in Chinese cohort.Our aim is to examine the genetic factor,genotype-phenotype correlations,and inheritance patterns of ARVC in a Chinese cohort.展开更多
Objective Genotype has been related to specific phenotype of hypertrophic cardiomyopathy (HCM) patients, but its relationship with histopathological alterations remains uncertain. The purpose of the study is to explor...Objective Genotype has been related to specific phenotype of hypertrophic cardiomyopathy (HCM) patients, but its relationship with histopathological alterations remains uncertain. The purpose of the study is to explore the relationship between the genotype and histopathological alterations under different genetic Backgrounds.展开更多
Objective To elucidate the transformation of energy metabolism patterns in the process of myocardial remodeling induced by volumeoverload and to explore a novel intervention target for the prevention,delay or even rev...Objective To elucidate the transformation of energy metabolism patterns in the process of myocardial remodeling induced by volumeoverload and to explore a novel intervention target for the prevention,delay or even reversal of structural heart dysfunction.Methods Thirty C57/BL6 mice,20-30 g,half male and half female,were randomly divided into model group(n=15)and sham operation group(n=15).Each group was divided into subacute phase(2 weeks after surgery,n=5),cardiac functional compensation phase(5 weeks after surgery,n=5)and decompensation phase(15 weeks after surgery,n=5).展开更多
Objective To investigate the risk factors for prolonged postoperative mechanical ventilation patients with atrioventricular septal defect(AVSD).Methods We retrospectively analyzed the clinical data of 76 patients with...Objective To investigate the risk factors for prolonged postoperative mechanical ventilation patients with atrioventricular septal defect(AVSD).Methods We retrospectively analyzed the clinical data of 76 patients with atrioventricular septal defect aged more than 18 years in our hospital from January 1^st 2011 to December 31^st 2017.展开更多
Objective Mitochondria serve as energy generators, and its energy metabolism disorder is a key factor in myocardial remodeling. The purpose of this study was to investigate the role of PINK1-Mfn2-Parkinmediated mitoch...Objective Mitochondria serve as energy generators, and its energy metabolism disorder is a key factor in myocardial remodeling. The purpose of this study was to investigate the role of PINK1-Mfn2-Parkinmediated mitochondrial autophagy in the development and progression of myocardial remodeling, which is important for mitochondrial quality control and maintenance of cellular energy metabolism homeostasis.展开更多
Background and Objective(TGA)is a rare life-threatening form of congenital heart disease(CHD)with little known etiology.The recurrence rate in siblings and offspring of TGA patients has been observed higher than gener...Background and Objective(TGA)is a rare life-threatening form of congenital heart disease(CHD)with little known etiology.The recurrence rate in siblings and offspring of TGA patients has been observed higher than general population,implying the contribution of genetic factors.Indeed,family studies identified copy number variants e.g.22q11.2 deletions and point mutations e.g.NKX2-5 underlying genetic susceptibility to TGA or other forms of CHD.However,these genetic variants revealed in family studies are seldom observed in sporadic TGA subjects,indicating a distinct genetic etiology in sporadic TGA that remains to be explored.We sought to explore the genetic etiology of sporadic TGA at different levels including mutations,genes and pathways.展开更多
Objective Vascular inflammation is an important component of the pathophysiology in cardiovascular diseases,such as atherosclerosis,hypertension,and aneurysms.In the last decade,microRNAs(miRNAs)have been revealed as ...Objective Vascular inflammation is an important component of the pathophysiology in cardiovascular diseases,such as atherosclerosis,hypertension,and aneurysms.In the last decade,microRNAs(miRNAs)have been revealed as novel regulators of vascular inflammation.Each miR NA suppresses a subset of genes,forming a complex regulatory network.Here,we performed miR microarray to profile miRNAs expression in coronary artery disease(CAD)patients and healthy controls and identified differentially expressed miR in CAD patients.MiR-197-3p is one of up regulated miRNAs,in this study we investigate its biological functions in vascular inflammation.展开更多
文摘Background Though type 2 diabetes mellitus(T2DM)is an important and independent risk factor for coronary artery disease(CAD)in general population,whether this feature also exists in patients with familial hypercholesterolemia(FH)is less determined.The current study aims to characterize the clinical,laboratory,coronary and genetic characteristics of the FH patients with T2DM compared with FH alone.
文摘Objective Vascular endothelial cells senescence is one of major risk factors for atherosclerotic diseases,which can be induced by endogenous peptides,such as angiotensin Ⅱ(Ang Ⅱ).However,the effect of chronic Ang Ⅱ stimulation on endothelial senescence remains unknown.Therefore,this study aims to investigate the changes in morphology and function of human umbilical vein endothelial cells(HUVECs)in response to the chronic stimulation of Ang Ⅱ.
文摘Objective To establish three-dimensional phenotyping system for congenital heart disease in mouse and to lay a foundation for the study of phenotype identification and mechanism of congenital heart disease.Methods Twelve SPF C57BL/6 J wild type pregnant mice(8-10 week-old)were randomly divided into control group(n=6)and experimental group(n=6).
文摘Background Cyanotic congenital heart disease(CCHD)is one ofthe most common birth anomaly,in which chronic hypoxia is the basic pathophysiological process.Researches in the protective mechanisms of cardiomyocytes to chronic hypoxia have the potential to provide novel treatment strategies for many patients.Metabolomics is a study of metabolism at global level,which capture global biochemical events by assaying thousands of small molecules in tissues,followed by application of bioinformatics to define metabolomic signatures of the targets.In order to describe the features of metabolic remodeling of the heart of CCHD,we conducted our study on the effect of hypoxia on metabolism of human heart by using tissue from patients with CCHD compared with that from patients with non-cyanotic CHD(NCCHD).
文摘Objective Calcium Voltage-Gated Channel Subunit Alpha1 C(CACNA1C)gene encodes an alpha-1 subunit of a voltage-dependent calcium channel.This subunit forms the pore through which calcium ions pass into the cell and plays an important role in regulating blood pressure.Smoking habit has been proven become the risk factor of hypertension.This study aimed to investigate the interaction of variants in CACNA1C gene with smoke in blood pressure(BP)responses to dietary sodium and potassium intervention.
文摘Background Relations of lipoprotein (a)(Lp[a]) and proprotein convertase substilisin/kexin type 9 (PCSK9) levels to coronary artery disease (CAD) have been well established in general population, while little is known about the association between Lp(a) or PCSK9 and atherosclerotic lesions of different artery sites in patients with familial hypercholesterolemia (FH).
文摘Background Arrhythmogenic right ventricular cardiomyopathy(ARVC)is an inherited primary cardiomyopathy characterized by myocardial degeneration with fibro-fatty replacement.Clinical and genetic features of ARVC were well identified in Caucasian cohorts,but seldom examined in Chinese cohort.Our aim is to examine the genetic factor,genotype-phenotype correlations,and inheritance patterns of ARVC in a Chinese cohort.
文摘Objective Genotype has been related to specific phenotype of hypertrophic cardiomyopathy (HCM) patients, but its relationship with histopathological alterations remains uncertain. The purpose of the study is to explore the relationship between the genotype and histopathological alterations under different genetic Backgrounds.
文摘Objective To elucidate the transformation of energy metabolism patterns in the process of myocardial remodeling induced by volumeoverload and to explore a novel intervention target for the prevention,delay or even reversal of structural heart dysfunction.Methods Thirty C57/BL6 mice,20-30 g,half male and half female,were randomly divided into model group(n=15)and sham operation group(n=15).Each group was divided into subacute phase(2 weeks after surgery,n=5),cardiac functional compensation phase(5 weeks after surgery,n=5)and decompensation phase(15 weeks after surgery,n=5).
文摘Objective To investigate the risk factors for prolonged postoperative mechanical ventilation patients with atrioventricular septal defect(AVSD).Methods We retrospectively analyzed the clinical data of 76 patients with atrioventricular septal defect aged more than 18 years in our hospital from January 1^st 2011 to December 31^st 2017.
文摘Objective Mitochondria serve as energy generators, and its energy metabolism disorder is a key factor in myocardial remodeling. The purpose of this study was to investigate the role of PINK1-Mfn2-Parkinmediated mitochondrial autophagy in the development and progression of myocardial remodeling, which is important for mitochondrial quality control and maintenance of cellular energy metabolism homeostasis.
文摘Background and Objective(TGA)is a rare life-threatening form of congenital heart disease(CHD)with little known etiology.The recurrence rate in siblings and offspring of TGA patients has been observed higher than general population,implying the contribution of genetic factors.Indeed,family studies identified copy number variants e.g.22q11.2 deletions and point mutations e.g.NKX2-5 underlying genetic susceptibility to TGA or other forms of CHD.However,these genetic variants revealed in family studies are seldom observed in sporadic TGA subjects,indicating a distinct genetic etiology in sporadic TGA that remains to be explored.We sought to explore the genetic etiology of sporadic TGA at different levels including mutations,genes and pathways.
文摘Objective Vascular inflammation is an important component of the pathophysiology in cardiovascular diseases,such as atherosclerosis,hypertension,and aneurysms.In the last decade,microRNAs(miRNAs)have been revealed as novel regulators of vascular inflammation.Each miR NA suppresses a subset of genes,forming a complex regulatory network.Here,we performed miR microarray to profile miRNAs expression in coronary artery disease(CAD)patients and healthy controls and identified differentially expressed miR in CAD patients.MiR-197-3p is one of up regulated miRNAs,in this study we investigate its biological functions in vascular inflammation.
