Objective:To investigate the effects of epidural spinal cord stimulation(ESCS) and treadmill training on the locomotion function and ultrastructure of spinal cord anterior horn after moderate spinal cord injury in rat...Objective:To investigate the effects of epidural spinal cord stimulation(ESCS) and treadmill training on the locomotion function and ultrastructure of spinal cord anterior horn after moderate spinal cord injury in rats.Method:Nine adult female Sprague-Dawley rats were randomly distributed into three groups:①spinal cord injury group(SI,n=3).②spinal cord injury plus ESCS group(SE,n=3).③spinal cord injury plus treadmill training group(TT,n=3).All rats received a moderate spinal cord injury surgery.Four weeks after surgery,rats in SE group received an electrode implantation procedure,with the electrode field covering spinal cord segments L2-S1.Four weeks after electrode implantation,rats received subthreshold ESCS for 30 min/d.Rats in TT group received 4cm/s treadmill training for 30min/d.Rats in SI group received no intervention,as a control group.All procedures in these three groups lasted four weeks.The open field Basso,Beattie and Bresnahan(BBB) scale was used before and after intervention to evaluate rats' hindlimb motor function.Result:After four weeks intervention,rats in TT group improved their open field locomotion scores to 20.In contrast,no significant improvement was observed in groups SI and SE.The morphology of synapses and neurons were similar regardless of whether rats had undergone ESCS,treadmill training or not.Conclusion:ESCS alone was not sufficient to improve the walking ability of spinal cord injured rats.ESCS or treadmill training alone might not contribute to the changes of ultrastructure in anterior horn of spinal cord that underlie the recovery of walking ability.Further research is needed to understand the contributions of combination of ESCS and treadmill training to the rehabilitation of spinal cord injured rats.展开更多
A new restoration algorithm based on double loops and alternant iterations is proposed to restore the object image effectively from a few frames of turbulence-degraded images, Based on the double loops, the iterative ...A new restoration algorithm based on double loops and alternant iterations is proposed to restore the object image effectively from a few frames of turbulence-degraded images, Based on the double loops, the iterative relations for estimating the turbulent point spread function PSF and object image alternately are derived. The restoration experiments have been made on computers, showing that the proposed algorithm can obtain the optimal estimations of the object and the point spread function, with the feasibility and practicality of the proposed algorithm being convincing.展开更多
The multi-compartment electric vehicle routing problem(EVRP)with soft time window and multiple charging types(MCEVRP-STW&MCT)is studied,in which electric multi-compartment vehicles that are environmentally friendl...The multi-compartment electric vehicle routing problem(EVRP)with soft time window and multiple charging types(MCEVRP-STW&MCT)is studied,in which electric multi-compartment vehicles that are environmentally friendly but need to be recharged in course of transport process,are employed.A mathematical model for this optimization problem is established with the objective of minimizing the function composed of vehicle cost,distribution cost,time window penalty cost and charging service cost.To solve the problem,an estimation of the distribution algorithm based on Lévy flight(EDA-LF)is proposed to perform a local search at each iteration to prevent the algorithm from falling into local optimum.Experimental results demonstrate that the EDA-LF algorithm can find better solutions and has stronger robustness than the basic EDA algorithm.In addition,when comparing with existing algorithms,the result shows that the EDA-LF can often get better solutions in a relatively short time when solving medium and large-scale instances.Further experiments show that using electric multi-compartment vehicles to deliver incompatible products can produce better results than using traditional fuel vehicles.展开更多
Spiking neural P systems with anti-spikes （ASN P systems） are variant forms of spiking neural P systems, which are inspired by inhibitory impulses/spikes or inhibitory synapses. The typical feature of ASN P systems ...Spiking neural P systems with anti-spikes （ASN P systems） are variant forms of spiking neural P systems, which are inspired by inhibitory impulses/spikes or inhibitory synapses. The typical feature of ASN P systems is when a neuron contains both spikes and anti-spikes, spikes and anti-spikes wil immediately annihilate each other in a maximal way. In this paper, a restricted variant of ASN P systems, cal ed ASN P systems without anni-hilating priority, is considered, where the annihilating rule is used as the standard rule, i.e., it is not obligatory to use in the neuron associated with both spikes and anti-spikes. If the annihilating rule is used in a neuron, the annihilation wil consume one time unit. As a result, such systems using two categories of spiking rules （identified by （a, a） and （a,a^-）） can achieve Turing completeness as number accepting devices.展开更多
基金supported by the National Natural Science Foundation of China with grant No. 60874035Tongji Hospital Research Fund with grant No. 2008013
文摘Objective:To investigate the effects of epidural spinal cord stimulation(ESCS) and treadmill training on the locomotion function and ultrastructure of spinal cord anterior horn after moderate spinal cord injury in rats.Method:Nine adult female Sprague-Dawley rats were randomly distributed into three groups:①spinal cord injury group(SI,n=3).②spinal cord injury plus ESCS group(SE,n=3).③spinal cord injury plus treadmill training group(TT,n=3).All rats received a moderate spinal cord injury surgery.Four weeks after surgery,rats in SE group received an electrode implantation procedure,with the electrode field covering spinal cord segments L2-S1.Four weeks after electrode implantation,rats received subthreshold ESCS for 30 min/d.Rats in TT group received 4cm/s treadmill training for 30min/d.Rats in SI group received no intervention,as a control group.All procedures in these three groups lasted four weeks.The open field Basso,Beattie and Bresnahan(BBB) scale was used before and after intervention to evaluate rats' hindlimb motor function.Result:After four weeks intervention,rats in TT group improved their open field locomotion scores to 20.In contrast,no significant improvement was observed in groups SI and SE.The morphology of synapses and neurons were similar regardless of whether rats had undergone ESCS,treadmill training or not.Conclusion:ESCS alone was not sufficient to improve the walking ability of spinal cord injured rats.ESCS or treadmill training alone might not contribute to the changes of ultrastructure in anterior horn of spinal cord that underlie the recovery of walking ability.Further research is needed to understand the contributions of combination of ESCS and treadmill training to the rehabilitation of spinal cord injured rats.
文摘A new restoration algorithm based on double loops and alternant iterations is proposed to restore the object image effectively from a few frames of turbulence-degraded images, Based on the double loops, the iterative relations for estimating the turbulent point spread function PSF and object image alternately are derived. The restoration experiments have been made on computers, showing that the proposed algorithm can obtain the optimal estimations of the object and the point spread function, with the feasibility and practicality of the proposed algorithm being convincing.
基金supported by the National Natural Science Foundation of China(71571076)the National Key R&D Program for the 13th-Five-Year-Plan of China(2018YFF0300301).
文摘The multi-compartment electric vehicle routing problem(EVRP)with soft time window and multiple charging types(MCEVRP-STW&MCT)is studied,in which electric multi-compartment vehicles that are environmentally friendly but need to be recharged in course of transport process,are employed.A mathematical model for this optimization problem is established with the objective of minimizing the function composed of vehicle cost,distribution cost,time window penalty cost and charging service cost.To solve the problem,an estimation of the distribution algorithm based on Lévy flight(EDA-LF)is proposed to perform a local search at each iteration to prevent the algorithm from falling into local optimum.Experimental results demonstrate that the EDA-LF algorithm can find better solutions and has stronger robustness than the basic EDA algorithm.In addition,when comparing with existing algorithms,the result shows that the EDA-LF can often get better solutions in a relatively short time when solving medium and large-scale instances.Further experiments show that using electric multi-compartment vehicles to deliver incompatible products can produce better results than using traditional fuel vehicles.
基金supported by the National Natural Science Foundation of China(6103300361100145+1 种基金91130034)the China Postdoctoral Science Foundation(2014M550389)
文摘Spiking neural P systems with anti-spikes （ASN P systems） are variant forms of spiking neural P systems, which are inspired by inhibitory impulses/spikes or inhibitory synapses. The typical feature of ASN P systems is when a neuron contains both spikes and anti-spikes, spikes and anti-spikes wil immediately annihilate each other in a maximal way. In this paper, a restricted variant of ASN P systems, cal ed ASN P systems without anni-hilating priority, is considered, where the annihilating rule is used as the standard rule, i.e., it is not obligatory to use in the neuron associated with both spikes and anti-spikes. If the annihilating rule is used in a neuron, the annihilation wil consume one time unit. As a result, such systems using two categories of spiking rules （identified by （a, a） and （a,a^-）） can achieve Turing completeness as number accepting devices.
