With the development of technology, the performance of vessel equipment is improved, the structure is more complicated, the automation level is enhanced, the source needed by maintenance is increased and the outlay is...With the development of technology, the performance of vessel equipment is improved, the structure is more complicated, the automation level is enhanced, the source needed by maintenance is increased and the outlay is rising day by day. For these questions, this paper analyzes the factors that affect the outlay of equipment maintenance, and describes the computational principle of the BP (back propagation) artificial neural network and its applications in the maintenance of naval ship and craft. Finally, a dynamic investment prediction model of outlay for the military equipment maintenance is designed. It is important for decreasing the entire life period outlay and drawing up the maintenance plan and programming to analyze the position and action of maintenance outlay in entire life period outlay.展开更多
A compact high-voltage repetitive nanosecond pulse generator(HRNPG)was developed for studying the technology of repetitive nanosecond pulse technology and its related application.The HRNPG mainly consists of a repetit...A compact high-voltage repetitive nanosecond pulse generator(HRNPG)was developed for studying the technology of repetitive nanosecond pulse technology and its related application.The HRNPG mainly consists of a repetitive charging module,a Tesla transformer and a sharpening switch.With its voltage lower than 1 kV,the primary repetitive charging circuit comprises two fast thyristors as its low-voltage switches.The spiral Tesla transformer acts as the main step-up component,and its peak transformation ratio is designed to be more than 100.A self-breakdown spark switch,i.e.the sharpening switch,is used to sharpen the output of the transformer and to generate nanosecond pulses.The HRNPG prototype is capable of generating pulses of 100 kV in peak with rise time 30 ns and the maximum repetition rate of 500 Hz on a 6 k load.Experimental results show,without any magnetic core,the developed Tesla transformer prototype can easily output high voltage while keeping itself small in size and light in weight,which is of significance for the compactness and portability of the pulse generator.The N2-insulated spark switch operated well at voltage close to 100 kV and the repetition rate within several hundreds of hertz.展开更多
Software testing is a very important phase of the software development process. It is a very difficult job for a software manager to allocate optimally the financial budget to a software project during testing. In thi...Software testing is a very important phase of the software development process. It is a very difficult job for a software manager to allocate optimally the financial budget to a software project during testing. In this paper the problem of optimal allocation of the software testing cost is studied. There exist several models focused on the development of software costs measuring the number of software errors remaining in the software during testing. The purpose of this paper is to use these models to formulate the optimization problems of resource allocation: Minimization of the total number of software errors remaining in the system. On the assumption that a software project consists of some independent modules, the presented approach extends previous work by defining new goal functions and extending the primary assumption and precondition.展开更多
The cooperative mechanism is one main issue in the decentralized supply chain system, especially in an asymmetric information structure. We analyze the non-cooperative game behavior of a 2-echelon distribution supply ...The cooperative mechanism is one main issue in the decentralized supply chain system, especially in an asymmetric information structure. We analyze the non-cooperative game behavior of a 2-echelon distribution supply chain, compare the results with the system optimal solution, and give the supplier dominated cooperative mechanisms. We also analyze the validity of our contract under the asymmetric retailers' holding cost information and give some useful conclusions.展开更多
A four-bar linkage mechanism with links fabricated from symmetric laminates was studied. The mass matrix of the beam dement was obtained in light of the mass distribution characteristics of composite materials. The st...A four-bar linkage mechanism with links fabricated from symmetric laminates was studied. The mass matrix of the beam dement was obtained in light of the mass distribution characteristics of composite materials. The stiffness matrix of the beam element was derived from the constitutive equations of each layer and the relationship between the strain distribution and the node displacement of the beam element. The specific damping capacity of the beam element was analyzed according to the strain distribution of the beam element and the strain energy dissipation caused by vibration in each direction of each layer; and the damping coefficients were obtained according to the principle that the total energy dissipation of the beam element was equal to the work done by the equivalent damping force during a cycle of vibration, from which the damping matrix of the dynamic equations was obtained. Using the finite element method, the dynamic analytic model of the mechanism was obtained. The dynamic responses and natural frequency of the mechanism were obtained by simulation, respectively, and those of the simulation obtained by the proposed model were analyzed and compared with the results obtained by the conventional model. The work provides theoretical basis to a certain extent for the further research on nonlinear vibration characteristics and optimum design of this kind of mechanism.展开更多
As the transmission line corridors become more and more rare in China,it is now inevitable for people to construct HVAC-HVDC hybrid transmission lines.The research on the electric field around the transmission lines p...As the transmission line corridors become more and more rare in China,it is now inevitable for people to construct HVAC-HVDC hybrid transmission lines.The research on the electric field around the transmission lines plays an important role in evaluating the electromagnetic environment nearby.However,few existing research now considered the mutual effect of HVAC-HVDC hybrid transmission lines.Thus,this research designed a program based on windows,which calculated the surface voltage gradient on the transmission lines and the electric field at ground level respectively.This research calculated the surface voltage gradient on the transmission lines by applying the improved method of successive images.For the electric field at ground level under AC transmission line,simulation charge method is used,while for the electric field at the ground level under DC transmission lines,deutsch assumption method is used.Comparing the results generated by the calculation with those in published literature,the program is reliable.Taking 500 kV transmission lines as an example,when considering the mutual effect of the HVAC-HVDC lines,the amplitude of the surface voltage gradient will increase by about 10%and the amplitude of the electric field at ground level will increase by about 8%,making the mutual effect of the AC and DC lines unneglectable. Larger part of the electric field at ground level under hybrid lines is produced by the DC line.Thus,in order to control the electric field at ground level under hybrid lines,it should pay more attention on that produced by the DC line.展开更多
The car sequencing problem(CSP)concerns a production sequence of different types of cars in the mixed-model assembly line.A hybrid algorithm is proposed to find an assembly sequence of CSP with minimum violations.Firs...The car sequencing problem(CSP)concerns a production sequence of different types of cars in the mixed-model assembly line.A hybrid algorithm is proposed to find an assembly sequence of CSP with minimum violations.Firstly,the hybrid algorithm is based on the tabu search and large neighborhood search(TLNS),servicing as the framework.Moreover,two components are incorporated into the hybrid algorithm.One is the parallel constructive heuristic(PCH)that is used to construct a set of initial solutions and find some high quality solutions,and the other is the small neighborhood search(SNS)which is designed to improve the new constructed solutions.The computational results show that the proposed hybrid algorithm(PCH+TLNS+SNS)obtains100best known values out of109public instances,among these89instances get their best known values with100%success rate.By comparing with the well-known related algorithms,computational results demonstrate the effectiveness,efficiency and robustness of the proposed algorithm.展开更多
A fast object detection method based on object region dissimilarity and 1-D AGADM(one dimensional average gray absolute difference maximum) between object and background isproposed for real-time defection of small off...A fast object detection method based on object region dissimilarity and 1-D AGADM(one dimensional average gray absolute difference maximum) between object and background isproposed for real-time defection of small offshore targets. Then computational complexity, antinoiseperformance, the signal-to-noise ratio (SNR) gain between original images and their results as afunction of SNR of original images and receiver operating characteristic (ROC) curve are analyzed andcompared with those existing methods of small target detection such as two dimensional average grayabsolute difference maximum (2-D AGADM), median contrast filter algorithm and multi-level filteralgorithm. Experimental results and theoretical analysis have shown that the proposed method hasfaster speed and more adaptability to small object shape and also yields improved SNR performance.展开更多
The data packet dropouts phenomenon is usually inevitable when information transmitted among communication networks. In this paper, the robust stabilization problem for uncertain networked control systems with data pa...The data packet dropouts phenomenon is usually inevitable when information transmitted among communication networks. In this paper, the robust stabilization problem for uncertain networked control systems with data packet dropouts is studied. First, an uncertain discrete-time switching system model is presented to describe these networked control systems. The stability equivalence is then proved between this switching system and an uncertain impulsive difference system.Moreover, a sufficient condition is obtained for the asymptotical stability of the nonlinear impulsive difference system. From this condition the robust stabilization problem is dealt with for the uncertain impulsive system. Main results are given in linear matrix inequalities. Finally a numerical example is given to illustrate the theoretical results.展开更多
In the area of control theory the time-delay systems have been investigated. It's well known that delays often result in instability, therefore, stability analysis of time-delay systems is an important subject in ...In the area of control theory the time-delay systems have been investigated. It's well known that delays often result in instability, therefore, stability analysis of time-delay systems is an important subject in control theory. As a result, many criteria for testing the stability of linear time-delay systems have been proposed. Significant progress has been made in the theory of impulsive systems and impulsive delay systems in recent years. However, the corresponding theory for uncertain impulsive systems and uncertain impulsive delay systems has not been fully developed. In this paper, robust stability criteria are established for uncertain linear delay impulsive systems by using Lyapunov function, Razumikhin techniques and the results obtained. Some examples are given to illustrate our theory.展开更多
In 2002,the Core Committee of the Institute for International Medical Education(IIME)developed the concept of Global Minimum Essential Requirements in Medical Education("essentials"),in which a set of minimu...In 2002,the Core Committee of the Institute for International Medical Education(IIME)developed the concept of Global Minimum Essential Requirements in Medical Education("essentials"),in which a set of minimum outcomes have been defined for the medical students to demonstrate at graduation.To attain these requirements,the Ministry of Education of the People’s Republic of China has proposed the Outstanding Clinician Cultivation Plan in the National Outline of Medium and Long-term Program for Education Reform and Development(2010-2020).Among the proposed seven outcomes in the"essentials",the core competence includes critical thinking and research,communication skills,and information management.To this end,we have taken various measures to maximally implement the Outstanding Clinician Cultivation Plan in pathophysiology teaching.In this meeting,I would like to share with our colleagues the thoughts to reform the functional experimental courses by a substantial interdisciplinary cooperation through Physiology,Pathophysiology and Pharmacology Departments.Based on the preliminary trials,we feel that the reform can ensure the resource sharing(teachers and the laboratory equipments),and also allows us to carry out the experiments gradually from basic skill training,unifactorial and multifactorial/integrative experiments,to the explorative scientific research,which is beneficial not only for the students but also for the young teachers in cultivating their creative thinking,communication skills,and information management.We also believe that getting in touch with the clinical patients in early stage during pathophysiology teaching will nurture the students with right professional values and humanitarian feelings in addition to eliciting the interests of learning.展开更多
AIM: To determine the safety, tolerability and pharmacokinetic parameters of a new drug recombinant human parathyroid hormone [rhPTH (1-84)] in healthy male Chinese subjects. METHODS: Thirty-six healthy male volunteer...AIM: To determine the safety, tolerability and pharmacokinetic parameters of a new drug recombinant human parathyroid hormone [rhPTH (1-84)] in healthy male Chinese subjects. METHODS: Thirty-six healthy male volunteers were randomly divided into 3 groups. The volunteers in these groups received single subcutaneous injection of rhPTH (1-84) in a dosage of 1, 2 and 4 μg/kg respectively. Blood samples were obtained before and after administration within 24 hours. The rhPTH concentrations in serum were determined by enzyme linked immunosorbent assay (ELISA). The pharmacokinetic parameters determined with use of standard noncompartmental analysis were the maximum serum concentration (Cmax), the time to attain that concentration (tmax), and the area under the serum concentration-time curve up to 24 hours(AUC0-24) and up to infinity (AUC0-∞). Dose proportionality of pharmacokinetic parameters (AUC, Cmax of every volunteer of each dosage and AUC was computed from log transformed data) and was examined by mean of analysis of variance (ANOVA) using SPSS software package. In the study, subjects’ symptoms, objective signs, and vital signs, including blood pressure, heart rate, respiratory rate and body temperature, were checked and 12-lead electrocardiography was recorded before and after drug administration within 24 hours. Routine laboratory tests, including hematology, blood biochemistry, serum electrolyte, and urinalysis, were performed before and after drug administration within at 24 hours. RESULTS: The specificity, sensitivity, linear range, precision and accuracy of the method were all satisfied for the determination of rhPTH in serum. The serum concentration-time curve of most volunteers clearly exhibited a double-peak profile, with the first peak appearing approximately 10 to 30 minutes and the second peak appearing approximately 1.5 to 2 hours after subcutaneous injection of the hormone. The concentrations of all subjects 24 hours after dosing in the three groups almost returned to physiologic placebo levels. The main pharmacokinetic parameters: the mean AUC0-24 values were 2359, 4009 and 9232 pg·mL-1·h for the three dosage groups, respectively, and AUC0-∞ values were 2371, 4018 and 9299 pg·mL-1·h, respectively, the mean Cmax values were 543, 981 and 1845 pg/mL, respectively, and the mean t1/2β were 1.85, 1.79 and 2.57 h, respectively. All parameters had no significant difference. Cmax and AUC of the three groups had the linear characteristic with the correlation coefficient(r) 0.9991 and 0.9945, respectively. No severe adverse events were noted during this study. CONCLUSION: rhPTH (1-84) in Chinese male subjects presents a linear pharmacokinetic characteristic. It has a favorable pharmacokinetics and safety profile that enables the drug to be explored in future clinical studies that target patients with osteoporosis. It could be recommend that the dose for PhaseⅡ clinical trial should be 100 μg per day as a singular agent.展开更多
文摘With the development of technology, the performance of vessel equipment is improved, the structure is more complicated, the automation level is enhanced, the source needed by maintenance is increased and the outlay is rising day by day. For these questions, this paper analyzes the factors that affect the outlay of equipment maintenance, and describes the computational principle of the BP (back propagation) artificial neural network and its applications in the maintenance of naval ship and craft. Finally, a dynamic investment prediction model of outlay for the military equipment maintenance is designed. It is important for decreasing the entire life period outlay and drawing up the maintenance plan and programming to analyze the position and action of maintenance outlay in entire life period outlay.
基金Project supported by National Natural Science Foundation of China （51107049）.
文摘A compact high-voltage repetitive nanosecond pulse generator(HRNPG)was developed for studying the technology of repetitive nanosecond pulse technology and its related application.The HRNPG mainly consists of a repetitive charging module,a Tesla transformer and a sharpening switch.With its voltage lower than 1 kV,the primary repetitive charging circuit comprises two fast thyristors as its low-voltage switches.The spiral Tesla transformer acts as the main step-up component,and its peak transformation ratio is designed to be more than 100.A self-breakdown spark switch,i.e.the sharpening switch,is used to sharpen the output of the transformer and to generate nanosecond pulses.The HRNPG prototype is capable of generating pulses of 100 kV in peak with rise time 30 ns and the maximum repetition rate of 500 Hz on a 6 k load.Experimental results show,without any magnetic core,the developed Tesla transformer prototype can easily output high voltage while keeping itself small in size and light in weight,which is of significance for the compactness and portability of the pulse generator.The N2-insulated spark switch operated well at voltage close to 100 kV and the repetition rate within several hundreds of hertz.
文摘Software testing is a very important phase of the software development process. It is a very difficult job for a software manager to allocate optimally the financial budget to a software project during testing. In this paper the problem of optimal allocation of the software testing cost is studied. There exist several models focused on the development of software costs measuring the number of software errors remaining in the software during testing. The purpose of this paper is to use these models to formulate the optimization problems of resource allocation: Minimization of the total number of software errors remaining in the system. On the assumption that a software project consists of some independent modules, the presented approach extends previous work by defining new goal functions and extending the primary assumption and precondition.
基金This project was supported by the National Science Foundation of China(7017015)The Teaching and Research Award Fund for Outstanding Young Teachers in Higher Education Institutions of MOEThe Excellent Young Teachers Fund of MOE and the Project of Suppor
文摘The cooperative mechanism is one main issue in the decentralized supply chain system, especially in an asymmetric information structure. We analyze the non-cooperative game behavior of a 2-echelon distribution supply chain, compare the results with the system optimal solution, and give the supplier dominated cooperative mechanisms. We also analyze the validity of our contract under the asymmetric retailers' holding cost information and give some useful conclusions.
基金Projects(50175031, 50565001) supported by the National Natural Science Foundation of China project (2003203) supported by the New Century Ten Hundred and Thousand Talent Project Special Foundation of Guangxi+1 种基金 project(0542005) supported by Guangxi Science Foundation project(205119) supported by the Key Project of Chinese Ministry of Education
文摘A four-bar linkage mechanism with links fabricated from symmetric laminates was studied. The mass matrix of the beam dement was obtained in light of the mass distribution characteristics of composite materials. The stiffness matrix of the beam element was derived from the constitutive equations of each layer and the relationship between the strain distribution and the node displacement of the beam element. The specific damping capacity of the beam element was analyzed according to the strain distribution of the beam element and the strain energy dissipation caused by vibration in each direction of each layer; and the damping coefficients were obtained according to the principle that the total energy dissipation of the beam element was equal to the work done by the equivalent damping force during a cycle of vibration, from which the damping matrix of the dynamic equations was obtained. Using the finite element method, the dynamic analytic model of the mechanism was obtained. The dynamic responses and natural frequency of the mechanism were obtained by simulation, respectively, and those of the simulation obtained by the proposed model were analyzed and compared with the results obtained by the conventional model. The work provides theoretical basis to a certain extent for the further research on nonlinear vibration characteristics and optimum design of this kind of mechanism.
文摘As the transmission line corridors become more and more rare in China,it is now inevitable for people to construct HVAC-HVDC hybrid transmission lines.The research on the electric field around the transmission lines plays an important role in evaluating the electromagnetic environment nearby.However,few existing research now considered the mutual effect of HVAC-HVDC hybrid transmission lines.Thus,this research designed a program based on windows,which calculated the surface voltage gradient on the transmission lines and the electric field at ground level respectively.This research calculated the surface voltage gradient on the transmission lines by applying the improved method of successive images.For the electric field at ground level under AC transmission line,simulation charge method is used,while for the electric field at the ground level under DC transmission lines,deutsch assumption method is used.Comparing the results generated by the calculation with those in published literature,the program is reliable.Taking 500 kV transmission lines as an example,when considering the mutual effect of the HVAC-HVDC lines,the amplitude of the surface voltage gradient will increase by about 10%and the amplitude of the electric field at ground level will increase by about 8%,making the mutual effect of the AC and DC lines unneglectable. Larger part of the electric field at ground level under hybrid lines is produced by the DC line.Thus,in order to control the electric field at ground level under hybrid lines,it should pay more attention on that produced by the DC line.
基金Project(51435009) supported by the National Natural Science Foundation of ChinaProject(LQ14E080002) supported by the Zhejiang Provincial Natural Science Foundation of ChinaProject supported by the K.C.Wong Magna Fund in Ningbo University,China
文摘The car sequencing problem(CSP)concerns a production sequence of different types of cars in the mixed-model assembly line.A hybrid algorithm is proposed to find an assembly sequence of CSP with minimum violations.Firstly,the hybrid algorithm is based on the tabu search and large neighborhood search(TLNS),servicing as the framework.Moreover,two components are incorporated into the hybrid algorithm.One is the parallel constructive heuristic(PCH)that is used to construct a set of initial solutions and find some high quality solutions,and the other is the small neighborhood search(SNS)which is designed to improve the new constructed solutions.The computational results show that the proposed hybrid algorithm(PCH+TLNS+SNS)obtains100best known values out of109public instances,among these89instances get their best known values with100%success rate.By comparing with the well-known related algorithms,computational results demonstrate the effectiveness,efficiency and robustness of the proposed algorithm.
基金National Defense Science Foundation of P.R.China
文摘A fast object detection method based on object region dissimilarity and 1-D AGADM(one dimensional average gray absolute difference maximum) between object and background isproposed for real-time defection of small offshore targets. Then computational complexity, antinoiseperformance, the signal-to-noise ratio (SNR) gain between original images and their results as afunction of SNR of original images and receiver operating characteristic (ROC) curve are analyzed andcompared with those existing methods of small target detection such as two dimensional average grayabsolute difference maximum (2-D AGADM), median contrast filter algorithm and multi-level filteralgorithm. Experimental results and theoretical analysis have shown that the proposed method hasfaster speed and more adaptability to small object shape and also yields improved SNR performance.
文摘The data packet dropouts phenomenon is usually inevitable when information transmitted among communication networks. In this paper, the robust stabilization problem for uncertain networked control systems with data packet dropouts is studied. First, an uncertain discrete-time switching system model is presented to describe these networked control systems. The stability equivalence is then proved between this switching system and an uncertain impulsive difference system.Moreover, a sufficient condition is obtained for the asymptotical stability of the nonlinear impulsive difference system. From this condition the robust stabilization problem is dealt with for the uncertain impulsive system. Main results are given in linear matrix inequalities. Finally a numerical example is given to illustrate the theoretical results.
基金This project was supported by the National Natural Science Foundation of China (60274007) NSERC-Canada.
文摘In the area of control theory the time-delay systems have been investigated. It's well known that delays often result in instability, therefore, stability analysis of time-delay systems is an important subject in control theory. As a result, many criteria for testing the stability of linear time-delay systems have been proposed. Significant progress has been made in the theory of impulsive systems and impulsive delay systems in recent years. However, the corresponding theory for uncertain impulsive systems and uncertain impulsive delay systems has not been fully developed. In this paper, robust stability criteria are established for uncertain linear delay impulsive systems by using Lyapunov function, Razumikhin techniques and the results obtained. Some examples are given to illustrate our theory.
文摘In 2002,the Core Committee of the Institute for International Medical Education(IIME)developed the concept of Global Minimum Essential Requirements in Medical Education("essentials"),in which a set of minimum outcomes have been defined for the medical students to demonstrate at graduation.To attain these requirements,the Ministry of Education of the People’s Republic of China has proposed the Outstanding Clinician Cultivation Plan in the National Outline of Medium and Long-term Program for Education Reform and Development(2010-2020).Among the proposed seven outcomes in the"essentials",the core competence includes critical thinking and research,communication skills,and information management.To this end,we have taken various measures to maximally implement the Outstanding Clinician Cultivation Plan in pathophysiology teaching.In this meeting,I would like to share with our colleagues the thoughts to reform the functional experimental courses by a substantial interdisciplinary cooperation through Physiology,Pathophysiology and Pharmacology Departments.Based on the preliminary trials,we feel that the reform can ensure the resource sharing(teachers and the laboratory equipments),and also allows us to carry out the experiments gradually from basic skill training,unifactorial and multifactorial/integrative experiments,to the explorative scientific research,which is beneficial not only for the students but also for the young teachers in cultivating their creative thinking,communication skills,and information management.We also believe that getting in touch with the clinical patients in early stage during pathophysiology teaching will nurture the students with right professional values and humanitarian feelings in addition to eliciting the interests of learning.
文摘AIM: To determine the safety, tolerability and pharmacokinetic parameters of a new drug recombinant human parathyroid hormone [rhPTH (1-84)] in healthy male Chinese subjects. METHODS: Thirty-six healthy male volunteers were randomly divided into 3 groups. The volunteers in these groups received single subcutaneous injection of rhPTH (1-84) in a dosage of 1, 2 and 4 μg/kg respectively. Blood samples were obtained before and after administration within 24 hours. The rhPTH concentrations in serum were determined by enzyme linked immunosorbent assay (ELISA). The pharmacokinetic parameters determined with use of standard noncompartmental analysis were the maximum serum concentration (Cmax), the time to attain that concentration (tmax), and the area under the serum concentration-time curve up to 24 hours(AUC0-24) and up to infinity (AUC0-∞). Dose proportionality of pharmacokinetic parameters (AUC, Cmax of every volunteer of each dosage and AUC was computed from log transformed data) and was examined by mean of analysis of variance (ANOVA) using SPSS software package. In the study, subjects’ symptoms, objective signs, and vital signs, including blood pressure, heart rate, respiratory rate and body temperature, were checked and 12-lead electrocardiography was recorded before and after drug administration within 24 hours. Routine laboratory tests, including hematology, blood biochemistry, serum electrolyte, and urinalysis, were performed before and after drug administration within at 24 hours. RESULTS: The specificity, sensitivity, linear range, precision and accuracy of the method were all satisfied for the determination of rhPTH in serum. The serum concentration-time curve of most volunteers clearly exhibited a double-peak profile, with the first peak appearing approximately 10 to 30 minutes and the second peak appearing approximately 1.5 to 2 hours after subcutaneous injection of the hormone. The concentrations of all subjects 24 hours after dosing in the three groups almost returned to physiologic placebo levels. The main pharmacokinetic parameters: the mean AUC0-24 values were 2359, 4009 and 9232 pg·mL-1·h for the three dosage groups, respectively, and AUC0-∞ values were 2371, 4018 and 9299 pg·mL-1·h, respectively, the mean Cmax values were 543, 981 and 1845 pg/mL, respectively, and the mean t1/2β were 1.85, 1.79 and 2.57 h, respectively. All parameters had no significant difference. Cmax and AUC of the three groups had the linear characteristic with the correlation coefficient(r) 0.9991 and 0.9945, respectively. No severe adverse events were noted during this study. CONCLUSION: rhPTH (1-84) in Chinese male subjects presents a linear pharmacokinetic characteristic. It has a favorable pharmacokinetics and safety profile that enables the drug to be explored in future clinical studies that target patients with osteoporosis. It could be recommend that the dose for PhaseⅡ clinical trial should be 100 μg per day as a singular agent.
