Nanomaterials with unique characteristics exhibit favorable therapeutic and diagnostic properties,implying their enormous potential as biomedical candidates. C60 has been used in gene- and drug-delivery, as imaging ag...Nanomaterials with unique characteristics exhibit favorable therapeutic and diagnostic properties,implying their enormous potential as biomedical candidates. C60 has been used in gene- and drug-delivery, as imaging agents, and as photosensitizers in cancer therapy. In this study, the influences of a cationic functionalized fullerene on cellular behavior of human colorectal cancer cell line(HT-29) were investigated. Results indicated that HT-29 treated with the studied compound showed a lower sensitivity but a significant impairment in migration and invasion by interfering with the activities of matrix metalloproteinases(MMP-2 and9). The presence of fullerene also altered the capacity of adhesion-related proteins to perform their activity,thereby inducing dramatically adverse effects on the cell physiological functions such as cell adhesion. Thus,our study suggests that this compound is a new potential anti-metastatic effector and a therapeutic component for malignant colorectal cancer.展开更多
Lanthanide-sensitized upconverting nanoparticles(UCNPs)are widely studied because of their unusual optical characteristics,such as large antenna-generated anti-Stokes shifts,high photostability,and narrow emission ban...Lanthanide-sensitized upconverting nanoparticles(UCNPs)are widely studied because of their unusual optical characteristics,such as large antenna-generated anti-Stokes shifts,high photostability,and narrow emission bandwidths,which can be harnessed for a variety of applications including bioimaging,sensing,information security and high-level anticounterfeiting.The diverse requirements of these applications typically require precise control over upconversion luminescence(UCL).Recently,the concept of energy migration upconversion has emerged as an effective approach to modulate UCL for various lanthanide ions.Moreover,it provides valuable insights into the fundamental comprehension of energy transfer mechanisms on the nanoscale,thereby contributing to the design of efficient lanthanide-sensitized UCNPs and their practical applications.Here we present a comprehensive overview of the latest developments in energy migration upconversion in lanthanide-sensitized nanoparticles for photon upconversion tuning,encompassing design strategies,mechanistic investigations and applications.Additionally,some future prospects in the field of energy migration upconversion are also discussed.展开更多
Bulk sulfur incorporating 3 wt% gold nano-powder is investigated as possible candidate to maximize the fraction of active material in the Li-S battery cathode.The material is prepared via simple mixing of gold with mo...Bulk sulfur incorporating 3 wt% gold nano-powder is investigated as possible candidate to maximize the fraction of active material in the Li-S battery cathode.The material is prepared via simple mixing of gold with molten sulfur at 120℃,quenching at room temperature,and grinding.Our comprehensive study reports relevant electrochemical data,advanced X-ray computed tomography(CT)imaging of the positive and negative electrodes,and a thorough structural and morphological characterization of the S:Au 97:3 w/w composite.This cathode exhibits high rate capability within the range from C/10 to 1C,a maximum capacity above 1300 mAh gs^(-1),and capacity retention between 85%and 91%after 100 cycles at 1C and C/3 rates.The novel formulation enables a sulfur fraction in the composite cathode film as high as 78 wt%,an active material loading of 5.7 mg cm^(-2),and an electrolyte/sulfur(E/S)ratio of 5μL mg^(-1),which lead to a maximum areal capacity of 5.4 mAh cm^(-2).X-ray CT at the micro-and nanoscale reveals the microstructural features of the positive electrode that favor fast conversion kinetics in the battery.Quantitative analysis of sulfur distribution in the porous cathode displays that electrodeposition during the initial cycle may trigger an activation process in the cell leading to improved performance.Furthermore,the tomography study reveals the characteristics of the lithium anode and the cell separator upon a galvanostatic test prolonged over 300 cycles at a 2C rate.展开更多
基金funded within the research contracts Nanocancer Friuli Venezia Giulia, Fra-2011University of TriesteItalian Ministry of Education MIUR (FIRB RBAP11ETKA and PRIN 2010N3T9M4 001)
文摘Nanomaterials with unique characteristics exhibit favorable therapeutic and diagnostic properties,implying their enormous potential as biomedical candidates. C60 has been used in gene- and drug-delivery, as imaging agents, and as photosensitizers in cancer therapy. In this study, the influences of a cationic functionalized fullerene on cellular behavior of human colorectal cancer cell line(HT-29) were investigated. Results indicated that HT-29 treated with the studied compound showed a lower sensitivity but a significant impairment in migration and invasion by interfering with the activities of matrix metalloproteinases(MMP-2 and9). The presence of fullerene also altered the capacity of adhesion-related proteins to perform their activity,thereby inducing dramatically adverse effects on the cell physiological functions such as cell adhesion. Thus,our study suggests that this compound is a new potential anti-metastatic effector and a therapeutic component for malignant colorectal cancer.
基金supported by Senior Talent Fund of Jiangsu University(No.5501310021)China Postdoctoral Science Foundation(No.2023M741419)+1 种基金the Young Elite Scientist Sponsorship Program by ZJAST(No.G301310002)Research Fund for International Scientists(No.22350710187).
文摘Lanthanide-sensitized upconverting nanoparticles(UCNPs)are widely studied because of their unusual optical characteristics,such as large antenna-generated anti-Stokes shifts,high photostability,and narrow emission bandwidths,which can be harnessed for a variety of applications including bioimaging,sensing,information security and high-level anticounterfeiting.The diverse requirements of these applications typically require precise control over upconversion luminescence(UCL).Recently,the concept of energy migration upconversion has emerged as an effective approach to modulate UCL for various lanthanide ions.Moreover,it provides valuable insights into the fundamental comprehension of energy transfer mechanisms on the nanoscale,thereby contributing to the design of efficient lanthanide-sensitized UCNPs and their practical applications.Here we present a comprehensive overview of the latest developments in energy migration upconversion in lanthanide-sensitized nanoparticles for photon upconversion tuning,encompassing design strategies,mechanistic investigations and applications.Additionally,some future prospects in the field of energy migration upconversion are also discussed.
基金supported by the grant “Fondo di Ateneo per la Ricerca Locale (FAR) 2019”, University of Ferraraperformed within the collaboration project “Accordo di Collaborazione Quadro 2015” between University of Ferrara (Department of Chemical and Pharmaceutical Sciences) and Sapienza University of Rome (Department of Chemistry)+2 种基金funding from The Faraday Institution LiSTAR programme (EP/ S003053/1, FIRG014)supported by funding from EPSRC (EP/K005030/1)the support of The Royal Academy of Engineering (CiET1718/59)。
文摘Bulk sulfur incorporating 3 wt% gold nano-powder is investigated as possible candidate to maximize the fraction of active material in the Li-S battery cathode.The material is prepared via simple mixing of gold with molten sulfur at 120℃,quenching at room temperature,and grinding.Our comprehensive study reports relevant electrochemical data,advanced X-ray computed tomography(CT)imaging of the positive and negative electrodes,and a thorough structural and morphological characterization of the S:Au 97:3 w/w composite.This cathode exhibits high rate capability within the range from C/10 to 1C,a maximum capacity above 1300 mAh gs^(-1),and capacity retention between 85%and 91%after 100 cycles at 1C and C/3 rates.The novel formulation enables a sulfur fraction in the composite cathode film as high as 78 wt%,an active material loading of 5.7 mg cm^(-2),and an electrolyte/sulfur(E/S)ratio of 5μL mg^(-1),which lead to a maximum areal capacity of 5.4 mAh cm^(-2).X-ray CT at the micro-and nanoscale reveals the microstructural features of the positive electrode that favor fast conversion kinetics in the battery.Quantitative analysis of sulfur distribution in the porous cathode displays that electrodeposition during the initial cycle may trigger an activation process in the cell leading to improved performance.Furthermore,the tomography study reveals the characteristics of the lithium anode and the cell separator upon a galvanostatic test prolonged over 300 cycles at a 2C rate.
