Types and characteristics of gastric dysplasia werestudied histopathologically. Besides the adenomatous,cryptal and globoid dysplasias, regenerative type of gas-tric dysplasia was described, especially about its histo...Types and characteristics of gastric dysplasia werestudied histopathologically. Besides the adenomatous,cryptal and globoid dysplasias, regenerative type of gas-tric dysplasia was described, especially about its histo-pathological features and histogenesis. The peculiarityof this type of gastric dysplasia just coincided with thefindings of gastric mucosal changes found in the inhabitantsliving in Liaodong Panisula-a high incidence area ofgastric cancer. According to the epidemiologic and histo-pathologic studies on the inhabitants of Zhuanghe Countyof Liaodong Panisula, it was found that high salted foodse.g. the salted pork and fish etc. showed strongmutagenecity. The authors detected that these were therisk factors and might be the leading cause of the gastricmucosal erosions and following by epithelial regenerativechanges. Malignant changes were detected in the regene-rative dysplastic lesions in pathologic sections. Therefore,gastric mucosal regeneration should not be oper looked asa precursor of gastric cancer in some cases.展开更多
This paper discussed 378 cases of lung cancer which were identified pathologically in the thoracic department of China Medical University from 1980～1986. The sections were stained with H.E., PAS-ab and Keratin, and c...This paper discussed 378 cases of lung cancer which were identified pathologically in the thoracic department of China Medical University from 1980～1986. The sections were stained with H.E., PAS-ab and Keratin, and compared with sections of 131 cases of lung cancer being confirmed beforehand from 1978～1984. Chinese cases showed epidermoid carcinoma 165 (male 146), adenocarcinoma 136(male 82), small cell carcinoma 29 (male 21), large cell carcinoma 19 (male 15) and the others 29 (male 27); Japanese cases were 59(50), 53(25), 3 (2), 11(10), 3(0) respectively. The cases under 40 years of age were 23(6.1%) in China, 3(2.3%)in Japan. Both of them have similar character of histology. But the incidence of lung cancer in youth is higher in China.展开更多
Objective:Multiple myeloma(MM)is a hematologically malignant clonal plasma cell disease.This study aims to explore the association between immunophenotypes and prognosis in patients with MM,to determine whether the ex...Objective:Multiple myeloma(MM)is a hematologically malignant clonal plasma cell disease.This study aims to explore the association between immunophenotypes and prognosis in patients with MM,to determine whether the expression of CD45 and CD200 is related to the prognosis of newly diagnosed MM(NDMM)patients,and to evaluate the significance of the combined expression of CD45 and CD200 in NDMM.Methods:A total of 123 NDMM patients admitted to Shengjing Hospital of China Medical University from July 2015 to August 2019 were enrolled.Five key immunophenotypic markers(including CD38,CD138,CD45,CD56,and CD200)were screened through flow cytometry and identified using random forest analysis and univariate Cox regression analysis.Patients were divided into 3 groups:Group A,CD45 and CD200 double-positive;Group B,CD45 or CD200 single-positive;Group C,CD45 and CD200 double-negative.Kaplan-Meier curves were used to analyze overall survival(OS)and progression-free survival(PFS)across groups.Multivariate Cox regression was performed to evaluate prognostic factors,and a nomogram was constructed based on these results.Results:The OS and PFS of single-positive groups for CD38,CD138,CD45,CD56,and CD200 were all shorter than those of their respective single-negative groups(all P<0.05).Significant differences were observed in OS(P<0.001)and PFS(P=0.001)among Groups A,B,and C.Group A had shorter OS and PFS(all P=0.001)compared to the Group B+C(cases from Group B and Group C were combined).CD45 and CD200 double-positive was an independent prognostic factor for NDMM[hazard ratio(HR)=2.178,95%confidence interval(CI)1.048 to 4.529;P=0.037].The nomogram and calibration curves constructed from multivariate Cox regression analysis demonstrated good concordance(concordance index=0.706;95%CI 0.661 to 0.751).Conclusion:NDMM patients with double-positive expression of CD45 and CD200 have significantly shorter OS and PFS.Compared with the use of either marker alone,the combined assessment of CD45 and CD200 may provide better prognostic stratification for MM patients.展开更多
Background and objective Heparanase has been thought to be a good molecular marker of tumor,and the heparanase expression level was correlated closely with tumor metastasis. In this study,we investigate the effects of...Background and objective Heparanase has been thought to be a good molecular marker of tumor,and the heparanase expression level was correlated closely with tumor metastasis. In this study,we investigate the effects of heparanase on angiogenesis and lymphangiogenesis of lung cancer and the relationship between heparanase expression and vascular endothelial growth factor (VEGF),vascular endothelial growth factor-C (VEGF-C). Methods Immunohistochemistry was used to detect the expression of heparanase,VEGF,VEGF-C protein and microvascular density (MVD),lymphatic vessel density (LVD) in 115 cases of non-small cell lung cancer (NSCLC) and 45 cases of adjacent normal tissue samples. Results Our results showed that heparanase expression was significantly increased in 91 (79.13%) of the 115 cases and correlated with lymph node metastasis (node positive rate 87.0%; node negative rate 36.8%; P=0.003). Heparanase positive expression cases have significantly higher concentration of microvascular density (MVD) and lymphatic vessel density (LVD) as compared with heparanase negative expression cases (P<0.01,P<0.01,respectively),heparanase expression was significantly correlated with VEGF,VEGF-C expression in NSCLC. Conclusion Heparanase overexpression was associated with angiogenesis and lymphangiogenesis of lung cancer,targeting of heparanase may represent a significant therapeutic potential for lung cancer.展开更多
OBJECTIVE Ketamine is an injectable anesthetic and recreational drug of abuse commonly used worldwide. Many experimental studies have shown that ketamine can impair cognitive function and induce psychotic states. Neur...OBJECTIVE Ketamine is an injectable anesthetic and recreational drug of abuse commonly used worldwide. Many experimental studies have shown that ketamine can impair cognitive function and induce psychotic states. Neuroinflammation has been suggested to play an important role in neurodegeneration. Meanwhile,ketamine has been showed to modulate the levels of inflammatory cytokines.Therefore,we sought to investigate whether the effects of ketamine on the central nervous system is associated with the inflammatory cytokines. METHODS We established acute(single or multiple intraperitoneal injection) and chronic(six months daily intraperitoneal injection) ketamine administration models in C57BL/6 mice,evaluated the spatial recognition memory and emotional response by applying the Y maze test and open field test. We analyzed the changes of inflammatory cytokines interleukin-6(IL-6),interleukin-1β(IL-1β) and tumor necrosis factor-α(TNF-α) levels in mouse hippocampus,employing Western blot,quantitative reverse transcriptase-polymerase chain reaction(qR T-PCR) and immunohistochemistry. RESULTS Ketamine induced spatial recognition memory deficit,reduced anxiety-like behaviors in mice after chronic administration,and it was dose-dependent. Moreover,we found that ketamine could increase the levels of mouse hippocampal inflammatory cytokines IL-6 and IL-1β after single,multiple and long-term administration in a dose-dependent manner. However,the level of TNF-α expressed differently in mouse hippocampus under different conditions. Single administration of ketamine increased the level of TNF-α,whereas multiple and long-term administration decreased it significantly. We considered that TNF-α might exist bi-directional regulatory pathway,which was associated with the dose and duration of ketamine administration. CONCLUSION Our results suggest that the alterations of inflammatory cytokines IL-6,IL-1β and TNF-α levels may be involved in the neurotoxicity of ketamine.展开更多
During 1984 to 1990, a comparative etiologic studyand primary prevention for stomach cancer was carriedout in a high risk area in Zhuanghe County of LiaoningProvince. Because of the increase of consumption of fr-esh v...During 1984 to 1990, a comparative etiologic studyand primary prevention for stomach cancer was carriedout in a high risk area in Zhuanghe County of LiaoningProvince. Because of the increase of consumption of fr-esh vegetables and fruits (Protective factors), decreaseof eating salted pork and fishes which was verified tohave strong mutagenecity (risk factors), acute inflamma-tion and erosions accompanying with chronic gastritis havegot striking improvement. At the same time, serum betac-arotene also raised gradually. The authors stressed thatimprovement of economic situation and dietary habits mayplay an important role in primary prevention of precurso-res of stomach cancer but decrease of incidence of thiscancer is an event of 30 years or more later as the letentperiod of stomach cancer is rather long.展开更多
A numerical analysis of the log-law behavior for the turbulent boundary layer of a wall-bounded flow is performed over a flat plate immersed in three nanofluids(Zn O-water,SiO_(2)-water,TiO_(2)-water).Numerical simula...A numerical analysis of the log-law behavior for the turbulent boundary layer of a wall-bounded flow is performed over a flat plate immersed in three nanofluids(Zn O-water,SiO_(2)-water,TiO_(2)-water).Numerical simulations using CFD code are employed to investigate the boundary layer and the hydrodynamic flow.To validate the current numerical model,measurement points from published works were used,and the compared results were in good compliance.Simulations were carried out for the velocity series of 0.04,0.4 and 4 m/s and nanoparticle concentrations0.1% and 5%.The influence of nanoparticles’ concentration on velocity,temperature profiles,wall shear stress,and turbulent intensity was investigated.The obtained results showed that the viscous sub-layer,the buffer layer,and the loglaw layer along the potential-flow layer could be analyzed based on their curving quality in the regions which have just a single wall distance.It was seen that the viscous sub-layer is the biggest area in comparison with other areas.Alternatively,the section where the temperature changes considerably correspond to the thermal boundary layer’s thickness goes a downward trend when the velocity decreases.The thermal boundary layer gets deep away from the leading edge.However,a rise in the volume fraction of nanoparticles indicated a minor impact on the shear stress developed in the wall.In all cases,the thickness of the boundary layer undergoes a downward trend as the velocity increases,whereas increasing the nanoparticle concentrations would enhance the thickness.More precisely,the log layer is closed with log law,and it is minimal between Y^(+)=50 and Y^(+)=95.The temperature for nanoparticle concentration φ=5%is higher than that for φ=0.1%,in boundary layers,for all studied nanofluids.However,it is established that the behavior is inverted from the value of Y^(+)=1 and the temperature for φ =0.1% is more important than the case of φ =5%.For turbulence intensity peak,this peak exists at Y^(+)=100 for v=4 m/s,Y^(+)=10 for v=0.4 m/s and Y^(+)=8 for v=0.04 m/s.展开更多
The preliminary results of our research with column chromatography inbrief is presented to separate and purify simultaneously various kinds offractions with biochemical and pharmaceutical activities from a kinds ofsna...The preliminary results of our research with column chromatography inbrief is presented to separate and purify simultaneously various kinds offractions with biochemical and pharmaceutical activities from a kinds ofsnake venom and to make the proceeding either simplicity or economy. 2g of dry agkistrodon halys pallas of Jiang Ze area dissolved with展开更多
The intraglomerular distribution of alpha 2-plasmin inhi-bitor (α2-PI), plasminogen (PLG), fibronectin (FN) andfibrinogen related antigen (FRA), were examined in 118 ca-ses of primary or secondary glomerular disease ...The intraglomerular distribution of alpha 2-plasmin inhi-bitor (α2-PI), plasminogen (PLG), fibronectin (FN) andfibrinogen related antigen (FRA), were examined in 118 ca-ses of primary or secondary glomerular disease by immuno-fluorescence method. The plasma concentrations of α2-PI,PLGand FRA were also measured simultaneously. The results ofthis study indicated that there was significant correlationbetween the deposition of α2-PI, PLG, FN, FRA and thedegree of histopathological changes in patients with severeglomerulonephritis. There was no significant correlation be-tween the intensity of α2-PI, PLG, FN and FRA depositionin glomeruli and the serum levels of α2-PI, PLG and FRA.展开更多
Artificial intelligence(AI)technology has been increasingly used in medical field with its rapid developments.Echocardiography is one of the best imaging methods for clinical diagnosis of heart diseases,and combining ...Artificial intelligence(AI)technology has been increasingly used in medical field with its rapid developments.Echocardiography is one of the best imaging methods for clinical diagnosis of heart diseases,and combining with AI could further improve its diagnostic efficiency.Though the applications of AI in echocardiography remained at a relatively early stage,a variety of automated quantitative and analytical techniques were rapidly emerging and initially entered clinical practice.The status of clinical applications of AI in echocardiography were reviewed in this article.展开更多
Objective To observe the value of deep learning echocardiographic intelligent model for evaluation on left ventricular(LV)regional wall motion abnormalities(RWMA).Methods Apical two-chamber,three-chamber and four-cham...Objective To observe the value of deep learning echocardiographic intelligent model for evaluation on left ventricular(LV)regional wall motion abnormalities(RWMA).Methods Apical two-chamber,three-chamber and four-chamber views two-dimensional echocardiograms were obtained prospectively in 205 patients with coronary heart disease.The model for evaluating LV regional contractile function was constructed using a five-fold cross-validation method to automatically identify the presence of RWMA or not,and the performance of this model was assessed taken manual interpretation of RWMA as standards.Results Among 205 patients,RWMA was detected in totally 650 segments in 83 cases.LV myocardial segmentation model demonstrated good efficacy for delineation of LV myocardium.The average Dice similarity coefficient for LV myocardial segmentation results in the apical two-chamber,three-chamber and four-chamber views was 0.85,0.82 and 0.88,respectively.LV myocardial segmentation model accurately segmented LV myocardium in apical two-chamber,three-chamber and four-chamber views.The mean area under the curve(AUC)of RWMA identification model was 0.843±0.071,with sensitivity of(64.19±14.85)%,specificity of(89.44±7.31)%and accuracy of(85.22±4.37)%.Conclusion Deep learning echocardiographic intelligent model could be used to automatically evaluate LV regional contractile function,hence rapidly and accurately identifying RWMA.展开更多
The author has observed the epithelium and basement membrane of uterus, oviduct and fimbriae in mice under the TEM by oral administration of AgNo<sub>3</sub> tracer. The results showed that there was obvio...The author has observed the epithelium and basement membrane of uterus, oviduct and fimbriae in mice under the TEM by oral administration of AgNo<sub>3</sub> tracer. The results showed that there was obvious deposit of argentum granules outside the basement membrane of mucosal epithelium of the uterus, oviduct and fimbriae as well as outside the basement membrane of uterine glands. And there was dilatation fully filled with high electron-dense argentum granules at the intercellular space just beneath the tight junction between the mucosal epithelial cells of uterus, oviduet, fimbriae. All these finding suggest that the uterus, oviduct and fimbriae serve as barriers to the heavy metal argentum ions.展开更多
To study the effects of Bai-Hua-Qian-Hu on cardiovascular system,emphasis was put on the research of Bai-Hua-Qian-Hu extracted with water and alcohol on coronary flow and some cardiovascular indices in both isolated p...To study the effects of Bai-Hua-Qian-Hu on cardiovascular system,emphasis was put on the research of Bai-Hua-Qian-Hu extracted with water and alcohol on coronary flow and some cardiovascular indices in both isolated preparations and intact normal animals. The results showed that extract obtained with water and alcohol （Pd-wa） increased coronary flow in isolated rabbit heart and in the anaesthetized cats, Pd-wa antagonised the strip contraction either in canine coronary artery or in rabbit aorta, and increased myocardial nutrient blood flow in mice, The values of LD<sub>50</sub> by peritoneal and intravenous injection proved that Pd-wa was very safe.展开更多
An epidemiologic health survey was carried out among 314 workers in one of grain elevators in Shenyang.A medical and occupational questionnaire was administered by trained interviewers. Spirometry was performed on sit...An epidemiologic health survey was carried out among 314 workers in one of grain elevators in Shenyang.A medical and occupational questionnaire was administered by trained interviewers. Spirometry was performed on site. 61.47% of the grain workers complained of one or more respiratory symptoms during or after exposure to airborne grain dust.The prevalence of various symptoms was significantly higher among grain workers than control subjects. 15.6% of the grain workers had episodes of grain fever. The mean values of V<sub>max75</sub>, V<sub>max50</sub>, and V<sub>max25</sub> was significantly lower for grain workers than control subjects, suggesting that the group of grain workers had evidence of small airway dysfunction. Pulmonary function abnormalities were associated with increased duration of employment in the grain elevator,smoking was also associated with deterioration of respiratory function.展开更多
Four Patients with tuberculous mediastinal lymphadenitis resembling leiomyoma of the oesophagus are presented. The differential diagnosis between this disease and leiomyoma of the oesophagus is discussed. In any adult...Four Patients with tuberculous mediastinal lymphadenitis resembling leiomyoma of the oesophagus are presented. The differential diagnosis between this disease and leiomyoma of the oesophagus is discussed. In any adult patient, especially young females with dysphagia and filling defects along the middle third of the oesophagus, the possibility of tuberculous mediastinal lymphadenitis should be considered in the differential diagnosis. The material here presented is based upon conventional radiologic methods which are also available in the developing countries.展开更多
We have reported that the central mechanism of acupuncture-induced PRL secretion in non-lactating rats are related to antagonizing hypothalamic dopamine activity; noradrenaline system played little significant role in...We have reported that the central mechanism of acupuncture-induced PRL secretion in non-lactating rats are related to antagonizing hypothalamic dopamine activity; noradrenaline system played little significant role in the acupuncture effect; Υ-aminobutyric-acid system perhaps participated in this effect.This paper further provided evidence that central serotonin and EOP play a stimulatory role in the acupuncture induced secretion of prolactin; acupuncture may antagonize inhibitory effect of H<sub>2</sub> histamine receptor activation on prolactin secretion; the possible role of H<sub>1</sub>-receptor needs further investigation.展开更多
基金This research was supported by the National "7.5" Research Grant on Cancer.
文摘Types and characteristics of gastric dysplasia werestudied histopathologically. Besides the adenomatous,cryptal and globoid dysplasias, regenerative type of gas-tric dysplasia was described, especially about its histo-pathological features and histogenesis. The peculiarityof this type of gastric dysplasia just coincided with thefindings of gastric mucosal changes found in the inhabitantsliving in Liaodong Panisula-a high incidence area ofgastric cancer. According to the epidemiologic and histo-pathologic studies on the inhabitants of Zhuanghe Countyof Liaodong Panisula, it was found that high salted foodse.g. the salted pork and fish etc. showed strongmutagenecity. The authors detected that these were therisk factors and might be the leading cause of the gastricmucosal erosions and following by epithelial regenerativechanges. Malignant changes were detected in the regene-rative dysplastic lesions in pathologic sections. Therefore,gastric mucosal regeneration should not be oper looked asa precursor of gastric cancer in some cases.
文摘This paper discussed 378 cases of lung cancer which were identified pathologically in the thoracic department of China Medical University from 1980～1986. The sections were stained with H.E., PAS-ab and Keratin, and compared with sections of 131 cases of lung cancer being confirmed beforehand from 1978～1984. Chinese cases showed epidermoid carcinoma 165 (male 146), adenocarcinoma 136(male 82), small cell carcinoma 29 (male 21), large cell carcinoma 19 (male 15) and the others 29 (male 27); Japanese cases were 59(50), 53(25), 3 (2), 11(10), 3(0) respectively. The cases under 40 years of age were 23(6.1%) in China, 3(2.3%)in Japan. Both of them have similar character of histology. But the incidence of lung cancer in youth is higher in China.
基金supported by the National Natural Science Foundation,China(81870166).
文摘Objective:Multiple myeloma(MM)is a hematologically malignant clonal plasma cell disease.This study aims to explore the association between immunophenotypes and prognosis in patients with MM,to determine whether the expression of CD45 and CD200 is related to the prognosis of newly diagnosed MM(NDMM)patients,and to evaluate the significance of the combined expression of CD45 and CD200 in NDMM.Methods:A total of 123 NDMM patients admitted to Shengjing Hospital of China Medical University from July 2015 to August 2019 were enrolled.Five key immunophenotypic markers(including CD38,CD138,CD45,CD56,and CD200)were screened through flow cytometry and identified using random forest analysis and univariate Cox regression analysis.Patients were divided into 3 groups:Group A,CD45 and CD200 double-positive;Group B,CD45 or CD200 single-positive;Group C,CD45 and CD200 double-negative.Kaplan-Meier curves were used to analyze overall survival(OS)and progression-free survival(PFS)across groups.Multivariate Cox regression was performed to evaluate prognostic factors,and a nomogram was constructed based on these results.Results:The OS and PFS of single-positive groups for CD38,CD138,CD45,CD56,and CD200 were all shorter than those of their respective single-negative groups(all P<0.05).Significant differences were observed in OS(P<0.001)and PFS(P=0.001)among Groups A,B,and C.Group A had shorter OS and PFS(all P=0.001)compared to the Group B+C(cases from Group B and Group C were combined).CD45 and CD200 double-positive was an independent prognostic factor for NDMM[hazard ratio(HR)=2.178,95%confidence interval(CI)1.048 to 4.529;P=0.037].The nomogram and calibration curves constructed from multivariate Cox regression analysis demonstrated good concordance(concordance index=0.706;95%CI 0.661 to 0.751).Conclusion:NDMM patients with double-positive expression of CD45 and CD200 have significantly shorter OS and PFS.Compared with the use of either marker alone,the combined assessment of CD45 and CD200 may provide better prognostic stratification for MM patients.
文摘Background and objective Heparanase has been thought to be a good molecular marker of tumor,and the heparanase expression level was correlated closely with tumor metastasis. In this study,we investigate the effects of heparanase on angiogenesis and lymphangiogenesis of lung cancer and the relationship between heparanase expression and vascular endothelial growth factor (VEGF),vascular endothelial growth factor-C (VEGF-C). Methods Immunohistochemistry was used to detect the expression of heparanase,VEGF,VEGF-C protein and microvascular density (MVD),lymphatic vessel density (LVD) in 115 cases of non-small cell lung cancer (NSCLC) and 45 cases of adjacent normal tissue samples. Results Our results showed that heparanase expression was significantly increased in 91 (79.13%) of the 115 cases and correlated with lymph node metastasis (node positive rate 87.0%; node negative rate 36.8%; P=0.003). Heparanase positive expression cases have significantly higher concentration of microvascular density (MVD) and lymphatic vessel density (LVD) as compared with heparanase negative expression cases (P<0.01,P<0.01,respectively),heparanase expression was significantly correlated with VEGF,VEGF-C expression in NSCLC. Conclusion Heparanase overexpression was associated with angiogenesis and lymphangiogenesis of lung cancer,targeting of heparanase may represent a significant therapeutic potential for lung cancer.
文摘OBJECTIVE Ketamine is an injectable anesthetic and recreational drug of abuse commonly used worldwide. Many experimental studies have shown that ketamine can impair cognitive function and induce psychotic states. Neuroinflammation has been suggested to play an important role in neurodegeneration. Meanwhile,ketamine has been showed to modulate the levels of inflammatory cytokines.Therefore,we sought to investigate whether the effects of ketamine on the central nervous system is associated with the inflammatory cytokines. METHODS We established acute(single or multiple intraperitoneal injection) and chronic(six months daily intraperitoneal injection) ketamine administration models in C57BL/6 mice,evaluated the spatial recognition memory and emotional response by applying the Y maze test and open field test. We analyzed the changes of inflammatory cytokines interleukin-6(IL-6),interleukin-1β(IL-1β) and tumor necrosis factor-α(TNF-α) levels in mouse hippocampus,employing Western blot,quantitative reverse transcriptase-polymerase chain reaction(qR T-PCR) and immunohistochemistry. RESULTS Ketamine induced spatial recognition memory deficit,reduced anxiety-like behaviors in mice after chronic administration,and it was dose-dependent. Moreover,we found that ketamine could increase the levels of mouse hippocampal inflammatory cytokines IL-6 and IL-1β after single,multiple and long-term administration in a dose-dependent manner. However,the level of TNF-α expressed differently in mouse hippocampus under different conditions. Single administration of ketamine increased the level of TNF-α,whereas multiple and long-term administration decreased it significantly. We considered that TNF-α might exist bi-directional regulatory pathway,which was associated with the dose and duration of ketamine administration. CONCLUSION Our results suggest that the alterations of inflammatory cytokines IL-6,IL-1β and TNF-α levels may be involved in the neurotoxicity of ketamine.
基金This research was supported in part by a Grant-Aid for Oversea Cancer Research from the Ministry of Education,Science and Cultrue of Japan and reported at the 9th Asia Pacific Cancer Conference(Lahore, Pakistan, 1989) and the 15th International Cancer Co
文摘During 1984 to 1990, a comparative etiologic studyand primary prevention for stomach cancer was carriedout in a high risk area in Zhuanghe County of LiaoningProvince. Because of the increase of consumption of fr-esh vegetables and fruits (Protective factors), decreaseof eating salted pork and fishes which was verified tohave strong mutagenecity (risk factors), acute inflamma-tion and erosions accompanying with chronic gastritis havegot striking improvement. At the same time, serum betac-arotene also raised gradually. The authors stressed thatimprovement of economic situation and dietary habits mayplay an important role in primary prevention of precurso-res of stomach cancer but decrease of incidence of thiscancer is an event of 30 years or more later as the letentperiod of stomach cancer is rather long.
基金support he received through General Research Project under the grant number (R.G.P.2/138/42)。
文摘A numerical analysis of the log-law behavior for the turbulent boundary layer of a wall-bounded flow is performed over a flat plate immersed in three nanofluids(Zn O-water,SiO_(2)-water,TiO_(2)-water).Numerical simulations using CFD code are employed to investigate the boundary layer and the hydrodynamic flow.To validate the current numerical model,measurement points from published works were used,and the compared results were in good compliance.Simulations were carried out for the velocity series of 0.04,0.4 and 4 m/s and nanoparticle concentrations0.1% and 5%.The influence of nanoparticles’ concentration on velocity,temperature profiles,wall shear stress,and turbulent intensity was investigated.The obtained results showed that the viscous sub-layer,the buffer layer,and the loglaw layer along the potential-flow layer could be analyzed based on their curving quality in the regions which have just a single wall distance.It was seen that the viscous sub-layer is the biggest area in comparison with other areas.Alternatively,the section where the temperature changes considerably correspond to the thermal boundary layer’s thickness goes a downward trend when the velocity decreases.The thermal boundary layer gets deep away from the leading edge.However,a rise in the volume fraction of nanoparticles indicated a minor impact on the shear stress developed in the wall.In all cases,the thickness of the boundary layer undergoes a downward trend as the velocity increases,whereas increasing the nanoparticle concentrations would enhance the thickness.More precisely,the log layer is closed with log law,and it is minimal between Y^(+)=50 and Y^(+)=95.The temperature for nanoparticle concentration φ=5%is higher than that for φ=0.1%,in boundary layers,for all studied nanofluids.However,it is established that the behavior is inverted from the value of Y^(+)=1 and the temperature for φ =0.1% is more important than the case of φ =5%.For turbulence intensity peak,this peak exists at Y^(+)=100 for v=4 m/s,Y^(+)=10 for v=0.4 m/s and Y^(+)=8 for v=0.04 m/s.
文摘The preliminary results of our research with column chromatography inbrief is presented to separate and purify simultaneously various kinds offractions with biochemical and pharmaceutical activities from a kinds ofsnake venom and to make the proceeding either simplicity or economy. 2g of dry agkistrodon halys pallas of Jiang Ze area dissolved with
文摘The intraglomerular distribution of alpha 2-plasmin inhi-bitor (α2-PI), plasminogen (PLG), fibronectin (FN) andfibrinogen related antigen (FRA), were examined in 118 ca-ses of primary or secondary glomerular disease by immuno-fluorescence method. The plasma concentrations of α2-PI,PLGand FRA were also measured simultaneously. The results ofthis study indicated that there was significant correlationbetween the deposition of α2-PI, PLG, FN, FRA and thedegree of histopathological changes in patients with severeglomerulonephritis. There was no significant correlation be-tween the intensity of α2-PI, PLG, FN and FRA depositionin glomeruli and the serum levels of α2-PI, PLG and FRA.
文摘Artificial intelligence(AI)technology has been increasingly used in medical field with its rapid developments.Echocardiography is one of the best imaging methods for clinical diagnosis of heart diseases,and combining with AI could further improve its diagnostic efficiency.Though the applications of AI in echocardiography remained at a relatively early stage,a variety of automated quantitative and analytical techniques were rapidly emerging and initially entered clinical practice.The status of clinical applications of AI in echocardiography were reviewed in this article.
文摘Objective To observe the value of deep learning echocardiographic intelligent model for evaluation on left ventricular(LV)regional wall motion abnormalities(RWMA).Methods Apical two-chamber,three-chamber and four-chamber views two-dimensional echocardiograms were obtained prospectively in 205 patients with coronary heart disease.The model for evaluating LV regional contractile function was constructed using a five-fold cross-validation method to automatically identify the presence of RWMA or not,and the performance of this model was assessed taken manual interpretation of RWMA as standards.Results Among 205 patients,RWMA was detected in totally 650 segments in 83 cases.LV myocardial segmentation model demonstrated good efficacy for delineation of LV myocardium.The average Dice similarity coefficient for LV myocardial segmentation results in the apical two-chamber,three-chamber and four-chamber views was 0.85,0.82 and 0.88,respectively.LV myocardial segmentation model accurately segmented LV myocardium in apical two-chamber,three-chamber and four-chamber views.The mean area under the curve(AUC)of RWMA identification model was 0.843±0.071,with sensitivity of(64.19±14.85)%,specificity of(89.44±7.31)%and accuracy of(85.22±4.37)%.Conclusion Deep learning echocardiographic intelligent model could be used to automatically evaluate LV regional contractile function,hence rapidly and accurately identifying RWMA.
文摘The author has observed the epithelium and basement membrane of uterus, oviduct and fimbriae in mice under the TEM by oral administration of AgNo<sub>3</sub> tracer. The results showed that there was obvious deposit of argentum granules outside the basement membrane of mucosal epithelium of the uterus, oviduct and fimbriae as well as outside the basement membrane of uterine glands. And there was dilatation fully filled with high electron-dense argentum granules at the intercellular space just beneath the tight junction between the mucosal epithelial cells of uterus, oviduet, fimbriae. All these finding suggest that the uterus, oviduct and fimbriae serve as barriers to the heavy metal argentum ions.
文摘To study the effects of Bai-Hua-Qian-Hu on cardiovascular system,emphasis was put on the research of Bai-Hua-Qian-Hu extracted with water and alcohol on coronary flow and some cardiovascular indices in both isolated preparations and intact normal animals. The results showed that extract obtained with water and alcohol （Pd-wa） increased coronary flow in isolated rabbit heart and in the anaesthetized cats, Pd-wa antagonised the strip contraction either in canine coronary artery or in rabbit aorta, and increased myocardial nutrient blood flow in mice, The values of LD<sub>50</sub> by peritoneal and intravenous injection proved that Pd-wa was very safe.
文摘An epidemiologic health survey was carried out among 314 workers in one of grain elevators in Shenyang.A medical and occupational questionnaire was administered by trained interviewers. Spirometry was performed on site. 61.47% of the grain workers complained of one or more respiratory symptoms during or after exposure to airborne grain dust.The prevalence of various symptoms was significantly higher among grain workers than control subjects. 15.6% of the grain workers had episodes of grain fever. The mean values of V<sub>max75</sub>, V<sub>max50</sub>, and V<sub>max25</sub> was significantly lower for grain workers than control subjects, suggesting that the group of grain workers had evidence of small airway dysfunction. Pulmonary function abnormalities were associated with increased duration of employment in the grain elevator,smoking was also associated with deterioration of respiratory function.
文摘Four Patients with tuberculous mediastinal lymphadenitis resembling leiomyoma of the oesophagus are presented. The differential diagnosis between this disease and leiomyoma of the oesophagus is discussed. In any adult patient, especially young females with dysphagia and filling defects along the middle third of the oesophagus, the possibility of tuberculous mediastinal lymphadenitis should be considered in the differential diagnosis. The material here presented is based upon conventional radiologic methods which are also available in the developing countries.
基金Project supported by the National Natural Science Fund
文摘We have reported that the central mechanism of acupuncture-induced PRL secretion in non-lactating rats are related to antagonizing hypothalamic dopamine activity; noradrenaline system played little significant role in the acupuncture effect; Υ-aminobutyric-acid system perhaps participated in this effect.This paper further provided evidence that central serotonin and EOP play a stimulatory role in the acupuncture induced secretion of prolactin; acupuncture may antagonize inhibitory effect of H<sub>2</sub> histamine receptor activation on prolactin secretion; the possible role of H<sub>1</sub>-receptor needs further investigation.
