To study the antifungal mechanism and structure-activity relationship of the azole compounds,four triazole compounds were designed and synthesized.All of them were confirmed by 1H-NMR.Antifungal activities of title co...To study the antifungal mechanism and structure-activity relationship of the azole compounds,four triazole compounds were designed and synthesized.All of them were confirmed by 1H-NMR.Antifungal activities of title compounds were evaluated.And the results of the preliminary antifungal test showed that all compounds exhibited inhibitory effects on C.albicans and C.neoformans,especially the effects of 8d and 8b showed more potent than fluconazole.展开更多
文摘To study the antifungal mechanism and structure-activity relationship of the azole compounds,four triazole compounds were designed and synthesized.All of them were confirmed by 1H-NMR.Antifungal activities of title compounds were evaluated.And the results of the preliminary antifungal test showed that all compounds exhibited inhibitory effects on C.albicans and C.neoformans,especially the effects of 8d and 8b showed more potent than fluconazole.
