Objective:While age has been recognized as a noteworthy factor in preoperative graft selection,the correlation between age and hamstring autograft diameter has been the subject of continued debate within the scientifi...Objective:While age has been recognized as a noteworthy factor in preoperative graft selection,the correlation between age and hamstring autograft diameter has been the subject of continued debate within the scientific community.This study aimed to explore the correlation between the diameter of autologous tendon grafts and age in anterior cruciate ligament reconstruction(ACLR).Methods:A retrospective review of 388 patients who underwent arthroscopic ACLR with hamstring autografts was performed.Patients were grouped by age to analyze differences in hamstring autograft dia-meter and tendon cross-sectional area(CSA).We explored the correlations between age and graft diameter and between age and the CSA of the popliteal tendon while controlling for the influence of other pertinent variables.Results:Compared with female patients,male patients presented significantly greater autograft diameters and hamstring tendon CSAs(P<0.05).Notably,graft diameter and hamstring tendon CSA varied significantly across different age groups(P<0.05);patients aged>32 years were substantially more likely to have a graft diameter exceeding 8 mm and a CSA surpassing 18.5 mm^(2) than their≤32-year-old counterparts were(P<0.05).Conclusion:This study revealed that graft diameter varies across different age groups,with age independently influencing graft diameter.展开更多
文摘目的基于心脏影像学特点和血清标志物分析持续性心房颤动(atrial fibrillation,AF)患者环肺静脉隔离+顶部线+后壁线的射频消融术后复发的危险因素,并建立列线图模型。方法选取2022年6月至2023年9月阜阳市第二人民医院收治的持续性AF患者172例,根据术后6个月是否复发分为复发组51例和未复发组121例。于术前常规予以心电图、经胸和食管心动图检查,同时检测血常规和相关生化指标,均行环肺静脉隔离+顶部线+后壁线的射频消融术治疗,术后随访6个月。用二元logistic分析患者术后复发的独立危险因素,建立并评估列线图模型的诊断效能。结果复发组左心房直径、左心房容积指数、中性粒细胞、中性粒细胞与淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)、B型钠尿肽、C反应蛋白高于未复发组,左心耳峰值填充流速、左心耳峰值排空流速、左心耳射血分数低于未复发组(P<0.01)。二元logistic回归分析显示,持续性AF患者左心房容积指数升高(OR=1.160,95%CI:1.006~1.337)、左心耳峰值排空流速降低(OR=0.740,95%CI:0.583~0.940)、左心耳射血分数降低(OR=0.608,95%CI:0.422~0.877)、B型钠尿肽升高(OR=1.017,95%CI:1.004~1.030)和NLR升高(OR=10.116,95%CI:1.316~77.755)是环肺静脉隔离+顶部线+后壁线的射频消融术后复发的独立危险因素(P<0.05,P<0.01)。以左心房容积指数、左心耳峰值排空流速、左心耳射血分数、B型钠尿肽、NLR构建的列线图模型预测持续性AF患者术后复发的曲线下面积为0.889(95%CI:0.833~0.932)。结论持续性AF患者心脏影像学参数左心房容积指数、左心耳峰值排空流速、左心耳射血分数及血清标志物B型钠尿肽、NLR与环肺静脉隔离+顶部线+后壁线的射频消融术后复发密切相关,且相关列线图模型对术后复发的诊断价值较佳。
文摘目的探讨肾炎康复片联合复方α-酮酸片治疗慢性肾脏病(chronickidney diseae,CKD)的疗效及对微炎症状态影响。方法选取医院收治的CKD病患者86例,随机分为对照组44例和观察组42例。对照组口服复方α-酮酸片,5片/次,3次/d;观察组在此基础上联用肾炎康复片5片/次,3次/d;两组治疗4周,对比两组治疗后疗效、肾脏疾病相关生存质量量表(kidney disease quality of life short form,KDTA)评分、中医证候积分及血清甘油三酯(triglyceride,TG)、总胆固醇(total cholesterol,TC)和低密度脂蛋白(low density lipoprotein,LDL-c)及超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)和白细胞介素-6(Interleukin6,IL-6)水平变化。结果治疗后观察组总有效率为95.24%(40/42);对照组总有效率为72.73%(32/44);治疗后观察组疗效明显较高(P<0.05);两组KDTA评分均明显降低(P<0.05),且观察组降低更明显(P<0.05);两组血清TG、TC和LDL-C水平、中医证候积分、血清hs-CRP、TNF-α和IL-6水平均明显降低(P<0.05),且观察组降低更明显(P<0.05);两组血清尿素氮(blood urea nitrogen,BUN)、血肌酐(serum creatinine,Scr)和估算的肾小球滤过率(estimated glomerular filtra-tionrate,eGFR)水平较治疗前均明显降低(P<0.05),且观察组改善更显著(P<0.05)。结论采用肾炎康复片联合复方α-酮酸片治疗CKD具有较好的临床疗效,可改善机体微炎症状态,多重机制保护肾脏,值得在临床上推广应用。
基金This work was supported by the Fundamental Research Funds for the Central Universities(WK9110000143)the USTC Research Funds of the Double First-Class Initiative(YD9110002060)the Health Research Program of Anhui(AHWJ2022b060)。
文摘Objective:While age has been recognized as a noteworthy factor in preoperative graft selection,the correlation between age and hamstring autograft diameter has been the subject of continued debate within the scientific community.This study aimed to explore the correlation between the diameter of autologous tendon grafts and age in anterior cruciate ligament reconstruction(ACLR).Methods:A retrospective review of 388 patients who underwent arthroscopic ACLR with hamstring autografts was performed.Patients were grouped by age to analyze differences in hamstring autograft dia-meter and tendon cross-sectional area(CSA).We explored the correlations between age and graft diameter and between age and the CSA of the popliteal tendon while controlling for the influence of other pertinent variables.Results:Compared with female patients,male patients presented significantly greater autograft diameters and hamstring tendon CSAs(P<0.05).Notably,graft diameter and hamstring tendon CSA varied significantly across different age groups(P<0.05);patients aged>32 years were substantially more likely to have a graft diameter exceeding 8 mm and a CSA surpassing 18.5 mm^(2) than their≤32-year-old counterparts were(P<0.05).Conclusion:This study revealed that graft diameter varies across different age groups,with age independently influencing graft diameter.
