Objective To qualitatively assess the diagnostic performance of dynamic contrast enhancement(DCE),diffusionweighted imaging(DWI),and T2-weighted imaging(T2WI),alone or in combination,in the evaluation of breast cancer...Objective To qualitatively assess the diagnostic performance of dynamic contrast enhancement(DCE),diffusionweighted imaging(DWI),and T2-weighted imaging(T2WI),alone or in combination,in the evaluation of breast cancer.Methods We retrospectively reviewed the records of 394 consecutive patients with pathologically confirmed breast lesions who had undergone 3-T magnetic resonance imaging(MRI).The morphological characteristics of breast lesions were evaluated using DCE,DWI,and T2WI based on BI-RADS lexicon descriptors by trained radiologists.Patients were categorized into mass and non-mass groups based on MRI characteristics of the lesions,and the differences between benign and malignant lesions in each group were compared.Clinical prediction models for breast cancer diagnosis were constructed using logistic regression analysis.Diagnostic efficacies were compared using the area under the receiver operating characteristic curve(AUC)and DeLong test.Results For mass-like lesions,all the morphological parameters significantly differentiated benign and malignant lesions on consensus DCE,DWI,and T2WI(P<0.05).The combined method(DCE+DWI+T2WI)had a higher AUC(0.865)than any of the individual modality(DCE:0.786;DWI:0.793;T2WI:0.809)(P<0.05).For non-mass-like lesions,DWI signal intensity was a significant predictor of malignancy(P=0.036),but the model using DWI alone had a low AUC(0.669).Conclusion Morphological assessment using the combination of DCE,DWI,and T2WI provides better diagnostic value in differentiating benign and malignant breast mass-like lesions than assessment with only one of the modalities.展开更多
目的探讨免疫功能正常人原发性中枢神经系统淋巴瘤(primary central nervous system lymphomas,PCNSL)单体素氢质子磁共振波谱(1H-MRS)的表现特点。方法收集经手术病理和活检证实的PCNSL和胶质瘤(Glioma,GM)的~1H-MRS各15例,对其MRS表...目的探讨免疫功能正常人原发性中枢神经系统淋巴瘤(primary central nervous system lymphomas,PCNSL)单体素氢质子磁共振波谱(1H-MRS)的表现特点。方法收集经手术病理和活检证实的PCNSL和胶质瘤(Glioma,GM)的~1H-MRS各15例,对其MRS表现进行回顾性分析,并将两组Cho/NAA、Cho/Cre、NAA/Cre的比值进行对比。结果 PCNSL及GB的强化区域~1H-MRS均出现NAA峰值下降,Cho峰升高,15例PCNSL均出现高耸的脂质(Lip)峰和(或)Lip、乳酸(Lac)双峰,15例GM中5例出现Lip峰,两组间NAA/Cre、Cho/Cre存在显著性差异,Cho/NAA无显著性差异。结论 PCNSL的MRS表现具有一定特点,尤其是强化区域出现明显升高的Lip峰或Lip、Lac双峰对诊断PCNSL具有特异性,传统MRI结合~1H-MRS表现可以提高对PCNSL的诊断准确率。展开更多
文摘Objective To qualitatively assess the diagnostic performance of dynamic contrast enhancement(DCE),diffusionweighted imaging(DWI),and T2-weighted imaging(T2WI),alone or in combination,in the evaluation of breast cancer.Methods We retrospectively reviewed the records of 394 consecutive patients with pathologically confirmed breast lesions who had undergone 3-T magnetic resonance imaging(MRI).The morphological characteristics of breast lesions were evaluated using DCE,DWI,and T2WI based on BI-RADS lexicon descriptors by trained radiologists.Patients were categorized into mass and non-mass groups based on MRI characteristics of the lesions,and the differences between benign and malignant lesions in each group were compared.Clinical prediction models for breast cancer diagnosis were constructed using logistic regression analysis.Diagnostic efficacies were compared using the area under the receiver operating characteristic curve(AUC)and DeLong test.Results For mass-like lesions,all the morphological parameters significantly differentiated benign and malignant lesions on consensus DCE,DWI,and T2WI(P<0.05).The combined method(DCE+DWI+T2WI)had a higher AUC(0.865)than any of the individual modality(DCE:0.786;DWI:0.793;T2WI:0.809)(P<0.05).For non-mass-like lesions,DWI signal intensity was a significant predictor of malignancy(P=0.036),but the model using DWI alone had a low AUC(0.669).Conclusion Morphological assessment using the combination of DCE,DWI,and T2WI provides better diagnostic value in differentiating benign and malignant breast mass-like lesions than assessment with only one of the modalities.
文摘目的探讨免疫功能正常人原发性中枢神经系统淋巴瘤(primary central nervous system lymphomas,PCNSL)单体素氢质子磁共振波谱(1H-MRS)的表现特点。方法收集经手术病理和活检证实的PCNSL和胶质瘤(Glioma,GM)的~1H-MRS各15例,对其MRS表现进行回顾性分析,并将两组Cho/NAA、Cho/Cre、NAA/Cre的比值进行对比。结果 PCNSL及GB的强化区域~1H-MRS均出现NAA峰值下降,Cho峰升高,15例PCNSL均出现高耸的脂质(Lip)峰和(或)Lip、乳酸(Lac)双峰,15例GM中5例出现Lip峰,两组间NAA/Cre、Cho/Cre存在显著性差异,Cho/NAA无显著性差异。结论 PCNSL的MRS表现具有一定特点,尤其是强化区域出现明显升高的Lip峰或Lip、Lac双峰对诊断PCNSL具有特异性,传统MRI结合~1H-MRS表现可以提高对PCNSL的诊断准确率。
