Bacterial DNA taken up by immune cells in a CpG motif-independent manner is translocated into endosome. Endosomal maturation is essential for subsequent bacterial DNA-mediated signal transduction. TLR9 is recruited in...Bacterial DNA taken up by immune cells in a CpG motif-independent manner is translocated into endosome. Endosomal maturation is essential for subsequent bacterial DNA-mediated signal transduction. TLR9 is recruited into endosome to recognize bacterial DNA and initiate the TLR/IL-1R signal transduction pathway. As a result , transcription factors NF-κB and AP-1 are activated, which, in turn, leads to proinflammatory cytokine expression and induces a strong acute Th1-like inflammatory response.展开更多
Objective: To investigate the anti-inflammation and analgesic effects of Quyuningtong paster (QYNTP). Method : Animal models of acute and subacute inflammations including ear edema caused by xylene , capillary permeab...Objective: To investigate the anti-inflammation and analgesic effects of Quyuningtong paster (QYNTP). Method : Animal models of acute and subacute inflammations including ear edema caused by xylene , capillary permeability increase by acetic acid in mice and plantar edema by albumen, granuloma by cotton ball in rats were made to observe the anti-inflammation effects of QYNTP . Animal models of pain including reaction of body torsion caused by acetic acid and irritations by heat plate in mice were adopted to study the analgesic action of QYNTP. Result: QYNTP could not only significantly inhibit the ear edema, depress the increase of capillary permeability in mice, but relieve the plantar edema and inhibit the granuloma in rats. In addition, it also remarkably reduce the frequency of body torsion reaction,prolong the latent period of the pain reactions and raise the pain threshold in mice. Conclusion : QYNTP has obvious anti-inflammation and analgesic effects.展开更多
文摘Bacterial DNA taken up by immune cells in a CpG motif-independent manner is translocated into endosome. Endosomal maturation is essential for subsequent bacterial DNA-mediated signal transduction. TLR9 is recruited into endosome to recognize bacterial DNA and initiate the TLR/IL-1R signal transduction pathway. As a result , transcription factors NF-κB and AP-1 are activated, which, in turn, leads to proinflammatory cytokine expression and induces a strong acute Th1-like inflammatory response.
文摘Objective: To investigate the anti-inflammation and analgesic effects of Quyuningtong paster (QYNTP). Method : Animal models of acute and subacute inflammations including ear edema caused by xylene , capillary permeability increase by acetic acid in mice and plantar edema by albumen, granuloma by cotton ball in rats were made to observe the anti-inflammation effects of QYNTP . Animal models of pain including reaction of body torsion caused by acetic acid and irritations by heat plate in mice were adopted to study the analgesic action of QYNTP. Result: QYNTP could not only significantly inhibit the ear edema, depress the increase of capillary permeability in mice, but relieve the plantar edema and inhibit the granuloma in rats. In addition, it also remarkably reduce the frequency of body torsion reaction,prolong the latent period of the pain reactions and raise the pain threshold in mice. Conclusion : QYNTP has obvious anti-inflammation and analgesic effects.
