Neuronal growth associated protein (GAP-43) is a membrane bound phosphoprotein found in the axonal growth cones of sprouting central nervous system axons. It is neuron specific and is proposed to play a critical role ...Neuronal growth associated protein (GAP-43) is a membrane bound phosphoprotein found in the axonal growth cones of sprouting central nervous system axons. It is neuron specific and is proposed to play a critical role in growth cone function during development of the nervous system or the regenerative recovery from axon injury. The injury leads to the transfection of fibroblasts with the GAP-43 gene, which result in increasing GAP-43 expression. GAP-43 is expressed at high levels during the course of recovery of brain injury. GAP-43 acts with calmodulin and G protein to regulate metabolic responses that initates axonal growth. It is important to reestablish neuronal structure and axonal sprouting. The level of GAP-43 returns to basal level once sprouting has finished. So more and more researchers attach importance to the study of GAP-43, which will improve the level of treatment with brain injury. [展开更多
Apoptosis is one of the most important causes, which results in the central neuronal system complication in hypoxic-ischemic brain damage (HIBD). Apoptosis occurs in the developing brain more than in the developed bra...Apoptosis is one of the most important causes, which results in the central neuronal system complication in hypoxic-ischemic brain damage (HIBD). Apoptosis occurs in the developing brain more than in the developed brain. Apoptosis can last several weeks and may be inverted its pathology by appropriate therapy. Caspase inhibitor, neurotrophic factors, anti-apoptosis gene Bcl-2, mild hypothermia,and early intervention play important roles in promoting neuronal cell survival and preventing from apoptosis through different mechanisms. It may be a new way for rehabilitation of HIBD. [展开更多
文摘Neuronal growth associated protein (GAP-43) is a membrane bound phosphoprotein found in the axonal growth cones of sprouting central nervous system axons. It is neuron specific and is proposed to play a critical role in growth cone function during development of the nervous system or the regenerative recovery from axon injury. The injury leads to the transfection of fibroblasts with the GAP-43 gene, which result in increasing GAP-43 expression. GAP-43 is expressed at high levels during the course of recovery of brain injury. GAP-43 acts with calmodulin and G protein to regulate metabolic responses that initates axonal growth. It is important to reestablish neuronal structure and axonal sprouting. The level of GAP-43 returns to basal level once sprouting has finished. So more and more researchers attach importance to the study of GAP-43, which will improve the level of treatment with brain injury. [
文摘Apoptosis is one of the most important causes, which results in the central neuronal system complication in hypoxic-ischemic brain damage (HIBD). Apoptosis occurs in the developing brain more than in the developed brain. Apoptosis can last several weeks and may be inverted its pathology by appropriate therapy. Caspase inhibitor, neurotrophic factors, anti-apoptosis gene Bcl-2, mild hypothermia,and early intervention play important roles in promoting neuronal cell survival and preventing from apoptosis through different mechanisms. It may be a new way for rehabilitation of HIBD. [
