The expression of the MT1 MMP mRNA (membrane type 1 matrix metalloproteinase) was measured by RT PCR method in 45 patients with laryngeal squamous cell carcinoma and the relationship between MT1 MMP positive rate and ...The expression of the MT1 MMP mRNA (membrane type 1 matrix metalloproteinase) was measured by RT PCR method in 45 patients with laryngeal squamous cell carcinoma and the relationship between MT1 MMP positive rate and 5 year survival rate was investigated in 18 cases.There were 28 males and 17 females,ranging in age from 34 to 78 years old.Of these patients,there were 7 in stage Ⅰ,9 in stage Ⅱ,15 in stage Ⅲ,9 in stage Ⅳ,5 in recurrent group.Results showed that the expression of MT1 MMP mRNA (MT1 MMP/ actin) was higher in tumor tissue (45 cases) (0 4511±0 1052) than that in adjacent tissue of tumor (35 cases) (0 3818±0 0680) (P<0 05).The expression level of MT1 MMPmRNA in tumor tissue on stage Ⅲ (15 cases) (0 4568±0 1185) was than stage Ⅱ (9 cases) (0 3413±0 0904) (P<0 05),and also was significantly higher in group of 20 patients with lymph node metastasis (0 4991±0 1197) than that in group of 20 patients with negative lymph node metastasis (0 3574±0 0741) (P<0 01).The 5 year survival rate in group of 10 patients with high expression level of MT1 MMPmRNA was significantly poorer than that in group of 8 patients with low expression level (40% vs 90%,P<0 01).It seemed closely relates between the expression of MT1 MMPmRNA and metastasis,prognosis of laryngeal carcinoma.展开更多
文摘The expression of the MT1 MMP mRNA (membrane type 1 matrix metalloproteinase) was measured by RT PCR method in 45 patients with laryngeal squamous cell carcinoma and the relationship between MT1 MMP positive rate and 5 year survival rate was investigated in 18 cases.There were 28 males and 17 females,ranging in age from 34 to 78 years old.Of these patients,there were 7 in stage Ⅰ,9 in stage Ⅱ,15 in stage Ⅲ,9 in stage Ⅳ,5 in recurrent group.Results showed that the expression of MT1 MMP mRNA (MT1 MMP/ actin) was higher in tumor tissue (45 cases) (0 4511±0 1052) than that in adjacent tissue of tumor (35 cases) (0 3818±0 0680) (P<0 05).The expression level of MT1 MMPmRNA in tumor tissue on stage Ⅲ (15 cases) (0 4568±0 1185) was than stage Ⅱ (9 cases) (0 3413±0 0904) (P<0 05),and also was significantly higher in group of 20 patients with lymph node metastasis (0 4991±0 1197) than that in group of 20 patients with negative lymph node metastasis (0 3574±0 0741) (P<0 01).The 5 year survival rate in group of 10 patients with high expression level of MT1 MMPmRNA was significantly poorer than that in group of 8 patients with low expression level (40% vs 90%,P<0 01).It seemed closely relates between the expression of MT1 MMPmRNA and metastasis,prognosis of laryngeal carcinoma.
