Objective To observe the value of cranial ultrasound for perioperative patients with acute severe traumatic brain injury(sTBI).Methods Data of 55 sTBI patients who underwent craniotomy were retrospectively analyzed.Th...Objective To observe the value of cranial ultrasound for perioperative patients with acute severe traumatic brain injury(sTBI).Methods Data of 55 sTBI patients who underwent craniotomy were retrospectively analyzed.The patients were divided into observation group(n=15)and control group(n=40)according to received perioperative cranial ultrasound or not.The general data and surgical data were compared between groups,and ultrasonic data of observation group were analyzed.Results The proportions of good prognosis 1 and 6 months after operation in observation group were both higher than those in control group,while the incidence of cerebral infarction in observation group was lower than that in control group(all P<0.05).No significant difference of general data nor other surgical data was found between groups(all P>0.05).Acute encephalocele occurred in 1 case in observation group during operation,and cranial ultrasound accurately showed the contralateral secondary epidural hematoma.Increased intracranial pressure in different degrees were found in all 15 cases(15/15,100%)in observation group after operation with transcranial color coded Doppler(TCCD)or transcranial Doppler(TCD),while cerebral vascular spasm was observed in 5 cases(5/15,33.33%),among them 4 cases(4/5,80.00%)were diagnosed cerebral infarction based on CT examination.Conclusion Cranial ultrasound could be used to evaluate changes of sTBI in perioperative period and guide adjusting treatment strategy in time,being valuable for reducing risk of postoperative cerebral infarction and improving prognosis.展开更多
目的探讨线粒体脑肌病伴高乳酸血症和脑卒中样发作(MELAS)综合征患者骨骼肌中抗线粒体抗体(AMA)的表达情况及凋亡因子Bcl-2、Bax、P53的作用。方法收集经临床、肌肉病理活检确诊的MELAS患者10例,正常健康者3例及非线粒体相关肌病(进行...目的探讨线粒体脑肌病伴高乳酸血症和脑卒中样发作(MELAS)综合征患者骨骼肌中抗线粒体抗体(AMA)的表达情况及凋亡因子Bcl-2、Bax、P53的作用。方法收集经临床、肌肉病理活检确诊的MELAS患者10例,正常健康者3例及非线粒体相关肌病(进行性肌营养不良)患者5例作为对照组。所有肌肉组织活检标本均行AMA、Bcl-2、Bax、P53免疫组织化学染色。结果光镜下AMA免疫组化染色可见,MELAS综合征患者骨骼肌中有大量棕褐色肌纤维,与Gomori染色下的不整红边纤维(ragged red fibers,RRF)形态类似。Bcl-2在3组患者的小血管中均有表达,在MELAS组的RRF下表达明显。Bax和P53在3组患者中均未见表达。结论 AMA在MELAS患者骨骼肌中的阳性表达可作为诊断MELAS综合征的一个病理指标,且其表达可能与患者的病情轻重有关系;MELAS中存在凋亡相关因素的调节,Bcl-2起到保护作用。展开更多
文摘Objective To observe the value of cranial ultrasound for perioperative patients with acute severe traumatic brain injury(sTBI).Methods Data of 55 sTBI patients who underwent craniotomy were retrospectively analyzed.The patients were divided into observation group(n=15)and control group(n=40)according to received perioperative cranial ultrasound or not.The general data and surgical data were compared between groups,and ultrasonic data of observation group were analyzed.Results The proportions of good prognosis 1 and 6 months after operation in observation group were both higher than those in control group,while the incidence of cerebral infarction in observation group was lower than that in control group(all P<0.05).No significant difference of general data nor other surgical data was found between groups(all P>0.05).Acute encephalocele occurred in 1 case in observation group during operation,and cranial ultrasound accurately showed the contralateral secondary epidural hematoma.Increased intracranial pressure in different degrees were found in all 15 cases(15/15,100%)in observation group after operation with transcranial color coded Doppler(TCCD)or transcranial Doppler(TCD),while cerebral vascular spasm was observed in 5 cases(5/15,33.33%),among them 4 cases(4/5,80.00%)were diagnosed cerebral infarction based on CT examination.Conclusion Cranial ultrasound could be used to evaluate changes of sTBI in perioperative period and guide adjusting treatment strategy in time,being valuable for reducing risk of postoperative cerebral infarction and improving prognosis.
文摘目的探讨线粒体脑肌病伴高乳酸血症和脑卒中样发作(MELAS)综合征患者骨骼肌中抗线粒体抗体(AMA)的表达情况及凋亡因子Bcl-2、Bax、P53的作用。方法收集经临床、肌肉病理活检确诊的MELAS患者10例,正常健康者3例及非线粒体相关肌病(进行性肌营养不良)患者5例作为对照组。所有肌肉组织活检标本均行AMA、Bcl-2、Bax、P53免疫组织化学染色。结果光镜下AMA免疫组化染色可见,MELAS综合征患者骨骼肌中有大量棕褐色肌纤维,与Gomori染色下的不整红边纤维(ragged red fibers,RRF)形态类似。Bcl-2在3组患者的小血管中均有表达,在MELAS组的RRF下表达明显。Bax和P53在3组患者中均未见表达。结论 AMA在MELAS患者骨骼肌中的阳性表达可作为诊断MELAS综合征的一个病理指标,且其表达可能与患者的病情轻重有关系;MELAS中存在凋亡相关因素的调节,Bcl-2起到保护作用。
