Objective:To study the clinical effect of neural stem cell transplantation in the treatment of inherited cerebellar atrophy (CA). Methods:The cells from human fetal cerebellum (8-10 weeks of gestation) were grown and ...Objective:To study the clinical effect of neural stem cell transplantation in the treatment of inherited cerebellar atrophy (CA). Methods:The cells from human fetal cerebellum (8-10 weeks of gestation) were grown and expanded in vitro. The cultured neurospheres were then implanted into the dentate nuclei of patients by stereo tactic operation. Totally,12 patients (7 males and 5 females with age ranging 22-62 years,mean 43 years) were treated by this operation from August 2006 to August 2008. Results:The cells of fetal cerebellum were expanded by 107 folds in undifferentiated state in the culture. After the operation,no rejection was detected. Follow up,the effective rates were 58.3% after 3 months,75.0% after 6 months,and 66.7% for 12-24 months (mean 18 months). Conclusion:the transplantation of in vitro cultured neural stem cell is a feasible and effective treatment for inherited CA,but the long term effectiveness need to be taken in consideration.展开更多
文摘Objective:To study the clinical effect of neural stem cell transplantation in the treatment of inherited cerebellar atrophy (CA). Methods:The cells from human fetal cerebellum (8-10 weeks of gestation) were grown and expanded in vitro. The cultured neurospheres were then implanted into the dentate nuclei of patients by stereo tactic operation. Totally,12 patients (7 males and 5 females with age ranging 22-62 years,mean 43 years) were treated by this operation from August 2006 to August 2008. Results:The cells of fetal cerebellum were expanded by 107 folds in undifferentiated state in the culture. After the operation,no rejection was detected. Follow up,the effective rates were 58.3% after 3 months,75.0% after 6 months,and 66.7% for 12-24 months (mean 18 months). Conclusion:the transplantation of in vitro cultured neural stem cell is a feasible and effective treatment for inherited CA,but the long term effectiveness need to be taken in consideration.
