Two novel lanthanide complexes,[Sm_(2)(BA)_(6)(4-OH-terpy)_(2)]·2H_(2)O·2EtOH(1)and[Pr_(2)(BA)_(6)(4-OH-terpy)_(2)(H_(2)O)_(2)]·HBA·H_(2)O(2),where HBA=benzoic acid,4-OH-terpy=4-hydroxy-2,2'∶6...Two novel lanthanide complexes,[Sm_(2)(BA)_(6)(4-OH-terpy)_(2)]·2H_(2)O·2EtOH(1)and[Pr_(2)(BA)_(6)(4-OH-terpy)_(2)(H_(2)O)_(2)]·HBA·H_(2)O(2),where HBA=benzoic acid,4-OH-terpy=4-hydroxy-2,2'∶6',2″-terpyridine,were successfully synthesized using ultrasonic dissolution and the conventional solution method with two mixed ligands HBA and 4-OH-terpy.During the synthesis,4-OH-terpy was involved in the reaction as a neutral ligand,while HBA,in its deprotonated form(BA-),coordinated with the lanthanide ions as an acidic ligand.The crystal structures of these two complexes were precisely determined by single-crystal X-ray diffraction.Elemental analysis,infrared and Raman spectroscopy,and powder X-ray diffraction techniques were also employed to further explore the physicochemical properties of the two complexes.The single-crystal X-ray diffraction data indicate that,despite their structural differences,both complexes belong to the triclinic crystal system P1 space group.The central lanthanide ions have the same coordination number but exhibit different coordination environments.To comprehensively evaluate the thermal stability of these two complexes,comprehensive tests including thermogravimetric analysis,differential thermogravimetric analysis,differential scanning calorimetry,Fourier transform infrared spectroscopy,and mass spectrometry were conducted.Meanwhile,an in-depth investigation was conducted into the 3D infrared stacked images and mass spectra of the gases emitted from the complexes.In addition,studies of the fluorescence properties of complex1 showed that it exhibited fluorescence emission matching the Sm^(3+)characteristic transition.展开更多
采用薄膜旋转蒸发-超声法分别制备了柠檬酸铁脂质体(FAC-Lip)和血红素铁脂质体(Heme-Lip).通过测定铁脂质体的体外释放,发现两种铁脂质体均具有缓释性,并且Heme-Lip的缓释性比FAC-Lip的好;采用平衡透析法测定了脂质体/水分配系数(P),并...采用薄膜旋转蒸发-超声法分别制备了柠檬酸铁脂质体(FAC-Lip)和血红素铁脂质体(Heme-Lip).通过测定铁脂质体的体外释放,发现两种铁脂质体均具有缓释性,并且Heme-Lip的缓释性比FAC-Lip的好;采用平衡透析法测定了脂质体/水分配系数(P),并考察影响分配系数的因素,初步探讨了FAC和Heme与脂质体膜结合的吉布斯自由能(ΔG),结果发现随着胆固醇含量和药脂比例的增加,P先增大后减小,当P最大时,药物与磷脂膜的氢键及静电作用力最大;在透析平衡时,计算得到了FAC-Lip和Heme-Lip中药物与脂质体膜层之间的吉布斯自由能分别为–12.7和–18.2 k J mol–1.展开更多
文摘Two novel lanthanide complexes,[Sm_(2)(BA)_(6)(4-OH-terpy)_(2)]·2H_(2)O·2EtOH(1)and[Pr_(2)(BA)_(6)(4-OH-terpy)_(2)(H_(2)O)_(2)]·HBA·H_(2)O(2),where HBA=benzoic acid,4-OH-terpy=4-hydroxy-2,2'∶6',2″-terpyridine,were successfully synthesized using ultrasonic dissolution and the conventional solution method with two mixed ligands HBA and 4-OH-terpy.During the synthesis,4-OH-terpy was involved in the reaction as a neutral ligand,while HBA,in its deprotonated form(BA-),coordinated with the lanthanide ions as an acidic ligand.The crystal structures of these two complexes were precisely determined by single-crystal X-ray diffraction.Elemental analysis,infrared and Raman spectroscopy,and powder X-ray diffraction techniques were also employed to further explore the physicochemical properties of the two complexes.The single-crystal X-ray diffraction data indicate that,despite their structural differences,both complexes belong to the triclinic crystal system P1 space group.The central lanthanide ions have the same coordination number but exhibit different coordination environments.To comprehensively evaluate the thermal stability of these two complexes,comprehensive tests including thermogravimetric analysis,differential thermogravimetric analysis,differential scanning calorimetry,Fourier transform infrared spectroscopy,and mass spectrometry were conducted.Meanwhile,an in-depth investigation was conducted into the 3D infrared stacked images and mass spectra of the gases emitted from the complexes.In addition,studies of the fluorescence properties of complex1 showed that it exhibited fluorescence emission matching the Sm^(3+)characteristic transition.
文摘采用薄膜旋转蒸发-超声法分别制备了柠檬酸铁脂质体(FAC-Lip)和血红素铁脂质体(Heme-Lip).通过测定铁脂质体的体外释放,发现两种铁脂质体均具有缓释性,并且Heme-Lip的缓释性比FAC-Lip的好;采用平衡透析法测定了脂质体/水分配系数(P),并考察影响分配系数的因素,初步探讨了FAC和Heme与脂质体膜结合的吉布斯自由能(ΔG),结果发现随着胆固醇含量和药脂比例的增加,P先增大后减小,当P最大时,药物与磷脂膜的氢键及静电作用力最大;在透析平衡时,计算得到了FAC-Lip和Heme-Lip中药物与脂质体膜层之间的吉布斯自由能分别为–12.7和–18.2 k J mol–1.
