DNA N4-methylacytosine(4mC)在DNA表达、修复和复制方面起着重要作用。准确地预测DNA 4mC位点是了解其功能行为的迫切需要,这将有助于药物发现和生物医学研究。相比于传统湿实验方法而言,基于机器学习的4mC位点识别方法不仅能节省大量...DNA N4-methylacytosine(4mC)在DNA表达、修复和复制方面起着重要作用。准确地预测DNA 4mC位点是了解其功能行为的迫切需要,这将有助于药物发现和生物医学研究。相比于传统湿实验方法而言,基于机器学习的4mC位点识别方法不仅能节省大量的经费,而且能快速大批量地获取4mC修饰位点。本研究对现有预测器进行了汇总分析,并对未来相关研究工作进行展望。展开更多
基金supported by the National Natural Science Foundation of China(Grant No.11571025Key Grant No.11331011)+2 种基金the BCMIISthe Beijing Natural Science Foundation(Grant Nos.1142003L140003)
基金The project was supported by the Doctoral Scientific Research Starting Foundation of Jingdezhen Ceramic Institute(Grant No.102/01003002031)the Scientific Program of Department of Education of Jiangxi Province of China(Grant Nos.GJJ190732,GJJ180737)the Natural Science Foundation Program of Jiangxi Province(Grant No.20202BABL211005).
基金the Doctoral Scientific Research Starting Foundation of Jingdezhen Ceramic University(Grant No.102/01003002031)the Scientific Program of Department of Education of Jiangxi Province of China(Grant No.GJJ190732)。