原子力显微镜(atomic force microscopy,AFM)是一种具有超高分辨率的新型探针显微镜,已广泛应用于生物医学领域。该研究利用AFM检测X射线对细胞形貌和杨氏模量的影响,结果显示照射后的细胞表面变得粗糙,细胞高度降低,杨氏模量减小,提示...原子力显微镜(atomic force microscopy,AFM)是一种具有超高分辨率的新型探针显微镜,已广泛应用于生物医学领域。该研究利用AFM检测X射线对细胞形貌和杨氏模量的影响,结果显示照射后的细胞表面变得粗糙,细胞高度降低,杨氏模量减小,提示细胞的刚性降低。进一步通过免疫荧光和流式细胞术实验发现,X射线能够破坏细胞骨架,损伤线粒体,进而诱发细胞凋亡。使用AFM研究辐射诱导的细胞损伤可以帮助人们了解辐射引起的组织病理改变,为一些放射病的诊断和治疗提供更多的理论依据。展开更多
Corrole,a representative branch of porphyrin,has recently gained popularity.These molecules,viewed as ring‑contracted porphyrinoids containing direct pyrrole‑pyrrole linkages due to the absence of a meso‑carbon atom,e...Corrole,a representative branch of porphyrin,has recently gained popularity.These molecules,viewed as ring‑contracted porphyrinoids containing direct pyrrole‑pyrrole linkages due to the absence of a meso‑carbon atom,exhibit significant photo‑physicochemical properties that make them attractive for various applications.Herein,this review comprehensively discusses the remarkable properties of corrole complexes,as well as related structures and chelation properties.It further explores the biological applications of corrole complexes for in vivo imaging and anticancer therapy.Additionally,it addresses common research bottlenecks and challenges,providing insights into future potential applications in disease diagnosis and treatment.Generally,this review aims to illuminate the significance of corrole complexes and their promising biological applications.展开更多
文摘原子力显微镜(atomic force microscopy,AFM)是一种具有超高分辨率的新型探针显微镜,已广泛应用于生物医学领域。该研究利用AFM检测X射线对细胞形貌和杨氏模量的影响,结果显示照射后的细胞表面变得粗糙,细胞高度降低,杨氏模量减小,提示细胞的刚性降低。进一步通过免疫荧光和流式细胞术实验发现,X射线能够破坏细胞骨架,损伤线粒体,进而诱发细胞凋亡。使用AFM研究辐射诱导的细胞损伤可以帮助人们了解辐射引起的组织病理改变,为一些放射病的诊断和治疗提供更多的理论依据。
文摘Corrole,a representative branch of porphyrin,has recently gained popularity.These molecules,viewed as ring‑contracted porphyrinoids containing direct pyrrole‑pyrrole linkages due to the absence of a meso‑carbon atom,exhibit significant photo‑physicochemical properties that make them attractive for various applications.Herein,this review comprehensively discusses the remarkable properties of corrole complexes,as well as related structures and chelation properties.It further explores the biological applications of corrole complexes for in vivo imaging and anticancer therapy.Additionally,it addresses common research bottlenecks and challenges,providing insights into future potential applications in disease diagnosis and treatment.Generally,this review aims to illuminate the significance of corrole complexes and their promising biological applications.
