The inclusion complexes of berberine hydrochloride with β-cyclodextrin was prepared by the method of saturated aqueous solution,its inclusion complex properties were represented with fluorescence,IR,NMR,X-ray and oth...The inclusion complexes of berberine hydrochloride with β-cyclodextrin was prepared by the method of saturated aqueous solution,its inclusion complex properties were represented with fluorescence,IR,NMR,X-ray and other spectral approaches.At the same time,the stoichiometric ratio,the constants and the thermodynamic parameters of inclusion complexes were determined.The experimental results demonstrated that a 1:1 inclusion complex of berberine hydrochloride with β-cyclodextrin was formed,and the thermodynamic function change of inclusion process was△G°<0 and△H°<0,the inclusion reaction was a spontaneous exothermal reaction.△S°<0,it was indicated that forming inclusion complex of berberine hydrochloride with β-cyclodextrin is an increased process for degree of order of molecules.Because the berberine hydrochloride/β-cyclodextrin inclusion complex can effectively improve its solubility,decrease side effect and thrill,increase its stability and bioavailability,a useful experimental data is provided for drugs exploitation and understanding interaction mechanism of inclusion complex between berberine hydrochloride and β-cyclodextrin by current work.展开更多
文摘The inclusion complexes of berberine hydrochloride with β-cyclodextrin was prepared by the method of saturated aqueous solution,its inclusion complex properties were represented with fluorescence,IR,NMR,X-ray and other spectral approaches.At the same time,the stoichiometric ratio,the constants and the thermodynamic parameters of inclusion complexes were determined.The experimental results demonstrated that a 1:1 inclusion complex of berberine hydrochloride with β-cyclodextrin was formed,and the thermodynamic function change of inclusion process was△G°<0 and△H°<0,the inclusion reaction was a spontaneous exothermal reaction.△S°<0,it was indicated that forming inclusion complex of berberine hydrochloride with β-cyclodextrin is an increased process for degree of order of molecules.Because the berberine hydrochloride/β-cyclodextrin inclusion complex can effectively improve its solubility,decrease side effect and thrill,increase its stability and bioavailability,a useful experimental data is provided for drugs exploitation and understanding interaction mechanism of inclusion complex between berberine hydrochloride and β-cyclodextrin by current work.
文摘利用响应面分析方法优化苦荞中黄酮的超声提取条件;在单因素试验的基础上,通过星点设计-中心组合法研究了超声功率、超声时间、超声温度、液固比对黄酮得率的影响。结果表明,黄酮最佳超声提取工艺条件为:超声提取功率50 W,超声提取时间26 min,超声提取温度53℃,液固比49 m L/g,提取次数2次,在此条件下黄酮得率为2.02%。
