Tramadol and its four metabolites O-desmethyltramadol,N-desmethyltramadol,N,O-didesmethyltramadol,Hydroxy tramadol were identified by GC-MS(EI,PCI).The contents and kinds of tramadol and its metabolites were compared ...Tramadol and its four metabolites O-desmethyltramadol,N-desmethyltramadol,N,O-didesmethyltramadol,Hydroxy tramadol were identified by GC-MS(EI,PCI).The contents and kinds of tramadol and its metabolites were compared between human urine and rat urine.The identical metabolites were found in human urine and rat urine but different contents.Some of the tramadol and its metabolites existing as conjugative and the others existing as educts in body were found after enzymatic hydrolysis.展开更多
文摘Tramadol and its four metabolites O-desmethyltramadol,N-desmethyltramadol,N,O-didesmethyltramadol,Hydroxy tramadol were identified by GC-MS(EI,PCI).The contents and kinds of tramadol and its metabolites were compared between human urine and rat urine.The identical metabolites were found in human urine and rat urine but different contents.Some of the tramadol and its metabolites existing as conjugative and the others existing as educts in body were found after enzymatic hydrolysis.
