目的:应用基于核磁共振氢谱(nuclear magnetic resonance1H,1H-NMR)的代谢组学方法比较慢性乙肝和重症乙肝患者血清代谢组。方法:对慢性乙肝患者血清(20例)和重症乙肝患者血清(11例)进行核磁共振氢谱检测,应用主成分分析方法找出慢性乙...目的:应用基于核磁共振氢谱(nuclear magnetic resonance1H,1H-NMR)的代谢组学方法比较慢性乙肝和重症乙肝患者血清代谢组。方法:对慢性乙肝患者血清(20例)和重症乙肝患者血清(11例)进行核磁共振氢谱检测,应用主成分分析方法找出慢性乙肝和重症乙肝患者血清代谢组差异。结果:与慢性乙肝患者血清代谢组比较,重肝患者血清中蛋氨酸、乙酰乙酸盐、三甲胺、葡萄糖和乳酸升高,而胆碱和脂的含量降低。结论:慢性乙肝和重症乙肝患者血清代谢组具有明显差异,基于核磁共振氢谱和主成分分析的代谢组学方法可以为重症乙肝的诊断提供代谢依据。展开更多
文摘目的:应用基于核磁共振氢谱(nuclear magnetic resonance1H,1H-NMR)的代谢组学方法比较慢性乙肝和重症乙肝患者血清代谢组。方法:对慢性乙肝患者血清(20例)和重症乙肝患者血清(11例)进行核磁共振氢谱检测,应用主成分分析方法找出慢性乙肝和重症乙肝患者血清代谢组差异。结果:与慢性乙肝患者血清代谢组比较,重肝患者血清中蛋氨酸、乙酰乙酸盐、三甲胺、葡萄糖和乳酸升高,而胆碱和脂的含量降低。结论:慢性乙肝和重症乙肝患者血清代谢组具有明显差异,基于核磁共振氢谱和主成分分析的代谢组学方法可以为重症乙肝的诊断提供代谢依据。
