1文献来源Chiorean EG,Cheung WY,Giordano G,et al.Real world comparative effectiveness of nab Paclitaxel plus Gemcitabine versus FOLFIRINOX in advanced pancreatic cancer:A systematic review[J].Ther Adv Med Oncol,2019 Ma...1文献来源Chiorean EG,Cheung WY,Giordano G,et al.Real world comparative effectiveness of nab Paclitaxel plus Gemcitabine versus FOLFIRINOX in advanced pancreatic cancer:A systematic review[J].Ther Adv Med Oncol,2019 May 19;11:1758835919850367.doi:10.1177/1758835919850367.2证据水平2a。3背景晚期胰腺癌(advanced pancreatic cancer,aPC)的治疗效果不佳,5年生存率约为3%。单药吉西他滨是aPC的标准治疗方案,但已证实疗效不如联合化疗方案如白蛋白紫杉醇联合吉西他滨(nab Paclitaxel/Gemcitabine,nab P/G)与FOLFIRINOX(氟尿嘧啶+亚叶酸钙+奥沙利铂+伊立替康)。社区治疗中肿瘤科医师对瘦弱的转移性胰腺癌(metastasis pancreatic cancer,mPC)患者倾向于选用nab P/G作为一线治疗,而对年轻男性患者倾向于选用FOLFIRINOX。然而,选择nab P/G或FOLFIRINOX的依据尚不清楚。展开更多
1文献来源研究一:Janssen QP,Buettner S,Suker M,et al.Neoadjuvant FOLFIRINOX in patients with borderline resectable pancreatic cancer:A systematic review and patient level meta analysis[J].J Natl Cancer Inst,2019,111(8)...1文献来源研究一:Janssen QP,Buettner S,Suker M,et al.Neoadjuvant FOLFIRINOX in patients with borderline resectable pancreatic cancer:A systematic review and patient level meta analysis[J].J Natl Cancer Inst,2019,111(8):782-794.研究二:Katz MH,Shi Q,Ahmad SA,et al.Preoperative modified FOLFIRINOX treatment followed by Capecitabine based chemoradiation for borderline resectable pancreatic cancer:Alliance for clinical trials in oncology trial A021101[J].JAMA Surg,2016,151(8):e161137.2证据水平1b。展开更多
1文献来源Middleton G,Palmer DH,Greenhalf W,et al.Vandetanib plus Gemcitabine versus placebo plus Gemcitabine in locally advanced or metastatic pancreatic carcinoma(ViP):A prospective,randomised,double blind,multicentr...1文献来源Middleton G,Palmer DH,Greenhalf W,et al.Vandetanib plus Gemcitabine versus placebo plus Gemcitabine in locally advanced or metastatic pancreatic carcinoma(ViP):A prospective,randomised,double blind,multicentre phase 2 trial[J].Lancet Oncol,2017,18(4):486-499.2证据水平1a。3背景吉西他滨单药疗法仍然是转移性胰腺癌患者的标准治疗方案。厄洛替尼是一种EGFR酪氨酸激酶抑制剂,与吉西他滨联合治疗局部进展期和转移性胰腺癌,能略改善患者的中位生存期。展开更多
1文献来源Conroy T,Hammel P,Hebbar M,et al.FOLFIRINOX or Gemcitabin as adjuvant therapy for pancreatic cancer[J].N Eng J Med,2018,379(25):2395-2406.2证据水平1b。3背景胰腺癌单纯手术治疗的5年生存率较低,即使接受了吉西他...1文献来源Conroy T,Hammel P,Hebbar M,et al.FOLFIRINOX or Gemcitabin as adjuvant therapy for pancreatic cancer[J].N Eng J Med,2018,379(25):2395-2406.2证据水平1b。3背景胰腺癌单纯手术治疗的5年生存率较低,即使接受了吉西他滨或者氟尿嘧啶辅助治疗,仍有大约70%的患者会在2年内出现转移复发[1 2]。因此,探索新的胰腺癌辅助治疗策略具有十分重要的临床意义。作为转移性胰腺癌的一线治疗,与吉西他滨单药化疗相比,FOLFIRINOX方案(持续泵注5 氟尿嘧啶+亚叶酸钙+伊立替康+奥沙利铂)明显延长了患者的总生存期(overall survival,OS)[3]。但FOLFIRINOX方案作为胰腺癌切除术后辅助治疗的价值尚不明确。展开更多
文摘1文献来源Chiorean EG,Cheung WY,Giordano G,et al.Real world comparative effectiveness of nab Paclitaxel plus Gemcitabine versus FOLFIRINOX in advanced pancreatic cancer:A systematic review[J].Ther Adv Med Oncol,2019 May 19;11:1758835919850367.doi:10.1177/1758835919850367.2证据水平2a。3背景晚期胰腺癌(advanced pancreatic cancer,aPC)的治疗效果不佳,5年生存率约为3%。单药吉西他滨是aPC的标准治疗方案,但已证实疗效不如联合化疗方案如白蛋白紫杉醇联合吉西他滨(nab Paclitaxel/Gemcitabine,nab P/G)与FOLFIRINOX(氟尿嘧啶+亚叶酸钙+奥沙利铂+伊立替康)。社区治疗中肿瘤科医师对瘦弱的转移性胰腺癌(metastasis pancreatic cancer,mPC)患者倾向于选用nab P/G作为一线治疗,而对年轻男性患者倾向于选用FOLFIRINOX。然而,选择nab P/G或FOLFIRINOX的依据尚不清楚。
文摘1文献来源研究一:Janssen QP,Buettner S,Suker M,et al.Neoadjuvant FOLFIRINOX in patients with borderline resectable pancreatic cancer:A systematic review and patient level meta analysis[J].J Natl Cancer Inst,2019,111(8):782-794.研究二:Katz MH,Shi Q,Ahmad SA,et al.Preoperative modified FOLFIRINOX treatment followed by Capecitabine based chemoradiation for borderline resectable pancreatic cancer:Alliance for clinical trials in oncology trial A021101[J].JAMA Surg,2016,151(8):e161137.2证据水平1b。
文摘1文献来源Middleton G,Palmer DH,Greenhalf W,et al.Vandetanib plus Gemcitabine versus placebo plus Gemcitabine in locally advanced or metastatic pancreatic carcinoma(ViP):A prospective,randomised,double blind,multicentre phase 2 trial[J].Lancet Oncol,2017,18(4):486-499.2证据水平1a。3背景吉西他滨单药疗法仍然是转移性胰腺癌患者的标准治疗方案。厄洛替尼是一种EGFR酪氨酸激酶抑制剂,与吉西他滨联合治疗局部进展期和转移性胰腺癌,能略改善患者的中位生存期。
文摘1文献来源Conroy T,Hammel P,Hebbar M,et al.FOLFIRINOX or Gemcitabin as adjuvant therapy for pancreatic cancer[J].N Eng J Med,2018,379(25):2395-2406.2证据水平1b。3背景胰腺癌单纯手术治疗的5年生存率较低,即使接受了吉西他滨或者氟尿嘧啶辅助治疗,仍有大约70%的患者会在2年内出现转移复发[1 2]。因此,探索新的胰腺癌辅助治疗策略具有十分重要的临床意义。作为转移性胰腺癌的一线治疗,与吉西他滨单药化疗相比,FOLFIRINOX方案(持续泵注5 氟尿嘧啶+亚叶酸钙+伊立替康+奥沙利铂)明显延长了患者的总生存期(overall survival,OS)[3]。但FOLFIRINOX方案作为胰腺癌切除术后辅助治疗的价值尚不明确。
