Carbon dots(CDs)are fluorescent carbon-based nanomaterials with sizes smal-ler than 10 nm,that are renowned for their exceptional properties,including superior anti-photobleaching,excellent biocompatibility,and minima...Carbon dots(CDs)are fluorescent carbon-based nanomaterials with sizes smal-ler than 10 nm,that are renowned for their exceptional properties,including superior anti-photobleaching,excellent biocompatibility,and minimal toxicity,which have received sig-nificant interest.Near-infrared(NIR)light has emerged as an ideal light source in the biolo-gical field due to its advantages of minimal scattering and absorption,long wavelength emission,increased tissue penetration,and reduced interference from biological back-grounds.CDs with efficient absorption and/or emission characteristics in the NIR spectrum have shown remarkable promise in the biomedical uses.This study provides a comprehens-ive overview of the preparation methods and wavelength modulation strategies for near-in-frared CDs and reviews research progress in their use in the areas of biosensing,bioimaging,and therapy.It also discusses current challenges and clinical prospects,aimed at deepening our understanding of the subject and promoting further advances in this field.展开更多
目的研究阴道分娩对子宫骶韧带(uterosacral ligaments,USLs)和主韧带(cardinal ligaments,CLs)生物力学性能的影响,进而探讨阴道分娩对盆腔器官脱垂(pelvic organ prolapse,POP)的影响。方法选用成年母猪(已育母猪5头,未育母猪5头)作...目的研究阴道分娩对子宫骶韧带(uterosacral ligaments,USLs)和主韧带(cardinal ligaments,CLs)生物力学性能的影响,进而探讨阴道分娩对盆腔器官脱垂(pelvic organ prolapse,POP)的影响。方法选用成年母猪(已育母猪5头,未育母猪5头)作为动物模型,通过单轴拉伸实验测量离体母猪的USLs和CLs被动力学行为,分析分娩对USLs和CLs生物力学性能的影响。结果猪子宫韧带组织的被动力学行为呈非线性。无论分娩与否,右骶韧带的最大应力大于左骶韧带(P<0.05);分娩后,二者力学性能存在显著差异。未育母猪左主韧带最大应力略大于右主韧带(P<0.05);分娩后,两者差异降低(P>0.05)。USLs最大应力均大于CLs,表明USLs比CLs承受的张力更大,USLs在POP中起到关键性作用。结论研究结果为认识USLs和CLs力学特性提供参考,可以指导更好治疗方法的发展,如POP手术重建,也为预防POP发生提供理论基础。展开更多
腰椎术后疼痛综合征(failed back surgery syndrome,FBSS)是指在一次或多次腰、骶椎手术后出现的持续性或反复发作的慢性疼痛[1]。有研究表明10%~40%的腰椎融合内固定术后病人会发生FBSS[2],持续的腰骶部、下肢疼痛严重影响病人生活质量...腰椎术后疼痛综合征(failed back surgery syndrome,FBSS)是指在一次或多次腰、骶椎手术后出现的持续性或反复发作的慢性疼痛[1]。有研究表明10%~40%的腰椎融合内固定术后病人会发生FBSS[2],持续的腰骶部、下肢疼痛严重影响病人生活质量。FBSS发病机制复杂。展开更多
基金financial support by Talent Introduction Research Initiation Fund of Shanxi Bethune Hospital(2022RC04)Basic Research Program Youth Science Research Project of Shanxi province(202203021212096)+1 种基金Shanxi Province Clinical Theranostics Technology Innovation Center for Immunologic and Rheumatic Diseases(CXZX-202302)Research Project Plan of Shanxi Provincial Administration of Traditional Chinese Medicine(2023ZYYB2021)。
文摘Carbon dots(CDs)are fluorescent carbon-based nanomaterials with sizes smal-ler than 10 nm,that are renowned for their exceptional properties,including superior anti-photobleaching,excellent biocompatibility,and minimal toxicity,which have received sig-nificant interest.Near-infrared(NIR)light has emerged as an ideal light source in the biolo-gical field due to its advantages of minimal scattering and absorption,long wavelength emission,increased tissue penetration,and reduced interference from biological back-grounds.CDs with efficient absorption and/or emission characteristics in the NIR spectrum have shown remarkable promise in the biomedical uses.This study provides a comprehens-ive overview of the preparation methods and wavelength modulation strategies for near-in-frared CDs and reviews research progress in their use in the areas of biosensing,bioimaging,and therapy.It also discusses current challenges and clinical prospects,aimed at deepening our understanding of the subject and promoting further advances in this field.
文摘目的研究阴道分娩对子宫骶韧带(uterosacral ligaments,USLs)和主韧带(cardinal ligaments,CLs)生物力学性能的影响,进而探讨阴道分娩对盆腔器官脱垂(pelvic organ prolapse,POP)的影响。方法选用成年母猪(已育母猪5头,未育母猪5头)作为动物模型,通过单轴拉伸实验测量离体母猪的USLs和CLs被动力学行为,分析分娩对USLs和CLs生物力学性能的影响。结果猪子宫韧带组织的被动力学行为呈非线性。无论分娩与否,右骶韧带的最大应力大于左骶韧带(P<0.05);分娩后,二者力学性能存在显著差异。未育母猪左主韧带最大应力略大于右主韧带(P<0.05);分娩后,两者差异降低(P>0.05)。USLs最大应力均大于CLs,表明USLs比CLs承受的张力更大,USLs在POP中起到关键性作用。结论研究结果为认识USLs和CLs力学特性提供参考,可以指导更好治疗方法的发展,如POP手术重建,也为预防POP发生提供理论基础。
