Alzheimer's disease(AD)is a prevalent neurodegenerative disease characterized by cognitive decline in the early stage.Mild cognitive impairment(MCI)is considered as an intermediate stage between normal aging and A...Alzheimer's disease(AD)is a prevalent neurodegenerative disease characterized by cognitive decline in the early stage.Mild cognitive impairment(MCI)is considered as an intermediate stage between normal aging and AD.In recent years,studies related to resting-state functional MRI(rs-fMRI)indicated that the occurrence and development process of MCI and AD might be closely linked to spontaneous brain activity and alterations in functional connectivity among brain regions,and rs-fMRI could provide important reference for specific diagnosis and early treatment of MCI and AD.The research progresses of rs-fMRI for MCI and AD were reviewed in this article.展开更多
文摘目的:分析新生儿入院时发生低体温的危险因素,为预防及干预提供借鉴。方法:检索国内外数据库中与新生儿入院低体温影响因素相关的队列研究、病例对照研究以及横断面研究,检索时限为数据库建库至2025年2月28日。采用RevMan 5.4进行Meta分析,计算并分析各影响因素合并OR值。结果:共纳入3篇病例对照研究、7篇队列研究和2篇横断面研究进行系统评价,其中低体温组7 096例,非低体温组4 367例。Meta分析结果显示,影响新生儿入院低体温发生情况的影响因素主要有5 min Apgar评分≥7分(OR=0.57)、产前使用糖皮质激素(OR=0.47)、出生体重<2 500 g(OR=3.61)、复苏史(OR=3.14)、剖宫产(OR=1.39),延迟开奶(OR=2.79)、窒息史(OR=3.97)、1 min Apgar评分≥7分(OR=0.48)、多胎(OR=1.67)、母亲产科并发症史(OR=5.26)、转运季节为寒冷季节(OR=2.31)。结论:新生儿入院低体温的发生受多因素影响,应对入院新生儿采取各种有针对性的预防措施,以减少新生儿入院低体温的发生。
文摘Alzheimer's disease(AD)is a prevalent neurodegenerative disease characterized by cognitive decline in the early stage.Mild cognitive impairment(MCI)is considered as an intermediate stage between normal aging and AD.In recent years,studies related to resting-state functional MRI(rs-fMRI)indicated that the occurrence and development process of MCI and AD might be closely linked to spontaneous brain activity and alterations in functional connectivity among brain regions,and rs-fMRI could provide important reference for specific diagnosis and early treatment of MCI and AD.The research progresses of rs-fMRI for MCI and AD were reviewed in this article.
