N-Methylmorpholine was synthesized by alkylation of morpholine with chloromethane in sodium hydroxide solution. The influences of reaction temperature, reaction time and molar ratio of reactants on the yield of the re...N-Methylmorpholine was synthesized by alkylation of morpholine with chloromethane in sodium hydroxide solution. The influences of reaction temperature, reaction time and molar ratio of reactants on the yield of the reaction were examined. The optimum reaction conditions are as follows: reaction temperature 35 ℃, time 5 h, n(morpholine)∶n(monochloromethane)=1∶1.1, n(morpholine)∶n(sodium hydroxide)= 1∶1.2, yield of N-methylmorpholine 85%, purity 98%.展开更多
Methoxyindole was synthesized in 4 steps starting from m cresol through nitrosation oxidation , etherification, condensation and reduction cyclization. The protecting piperidine group was at last removed from the enam...Methoxyindole was synthesized in 4 steps starting from m cresol through nitrosation oxidation , etherification, condensation and reduction cyclization. The protecting piperidine group was at last removed from the enamine with Raney nickel as catalyst to give 5 methoxyindole. The total yield was 34.3%.展开更多
文摘N-Methylmorpholine was synthesized by alkylation of morpholine with chloromethane in sodium hydroxide solution. The influences of reaction temperature, reaction time and molar ratio of reactants on the yield of the reaction were examined. The optimum reaction conditions are as follows: reaction temperature 35 ℃, time 5 h, n(morpholine)∶n(monochloromethane)=1∶1.1, n(morpholine)∶n(sodium hydroxide)= 1∶1.2, yield of N-methylmorpholine 85%, purity 98%.
文摘Methoxyindole was synthesized in 4 steps starting from m cresol through nitrosation oxidation , etherification, condensation and reduction cyclization. The protecting piperidine group was at last removed from the enamine with Raney nickel as catalyst to give 5 methoxyindole. The total yield was 34.3%.
