目的:探讨超声引导下细针穿刺活检(ultrasound guided fine needle aspiration biopsy,US-FNAB)对甲状腺结节的诊断价值。方法:回顾性分析天津医科大学总医院2016年1月至2017年4月行US-FNAB检查的甲状腺结节患者的临床特点及细胞病理诊...目的:探讨超声引导下细针穿刺活检(ultrasound guided fine needle aspiration biopsy,US-FNAB)对甲状腺结节的诊断价值。方法:回顾性分析天津医科大学总医院2016年1月至2017年4月行US-FNAB检查的甲状腺结节患者的临床特点及细胞病理诊断结果,对细胞诊断结果和手术病理结果进行对照分析。结果:在1 241例病例中,甲状腺结节男女比1:3.83(257/984),甲状腺结节的发病率从20岁开始逐年增加,60岁以后发病率开始下降。肿瘤最大径≤1.0 cm的结节640例(51.57%),TI-RADS 4级的结节1 072例(86.38%)。细胞学诊断结果中无法诊断的病例273例(22.00%),良性121例(9.75%),意义不明确的细胞非典型病变380例(30.62%),可疑恶性399例(32.15%),恶性68例(5.48%)。其中在天津医科大学总医院行手术的302例患者中,US-FNAB细胞病理有明确诊断203例,无法诊断21例,意义不明确的细胞非典型病变78例。203例明确诊断的病例中,US-FNAB诊断的灵敏度为100.00%(201/201),特异度为50.00%(1/2),阳性预测值99.50%(201/202),阴性预测值100.00%(1/1),诊断的准确率99.51%(202/203),误诊率0.49%(1/203)。在细胞学诊断为意义不明确的细胞非典型病变的78例中,恶性率70.51%。意义不明确细胞非典型病变是否为恶性与患者的年龄、性别、肿瘤大小和部位均无关(均P>0.05),与甲状腺超声影像报告和数据系统(thyroid imaging reporting and data system,TI-RADS)分级有关(P<0.05)。结论:US-FNAB对甲状腺结节有较高的诊断价值,值得推广应用,可以考虑部分代替术中冰冻,减少术中等候时间和患者的经济负担。展开更多
Objective\ \ To measure the level of osteocalcin (BGP) in ovariectomized rat and study its significance. Methods\ 20 female SD inbred rats were divided into sham ovariectomized (sham OVX) group and ovariectomized grou...Objective\ \ To measure the level of osteocalcin (BGP) in ovariectomized rat and study its significance. Methods\ 20 female SD inbred rats were divided into sham ovariectomized (sham OVX) group and ovariectomized group (OVX). 18 weeks postsurgery, serum and 24 hour urine were collected to measure BGP by radioimmunoassay. Serum Ca, P concentration, alkaline phosphatase activity, urine Ca, P and hydroxyproline were also measured. Results \ Compared with sham OVX rat, the BGP level of OVX rats (0 98±0 14μg/L)was markdly lower than that of sham OVX rat (1 50±0 32μg/L, P<0 01),and serum Ca, P were also reduced. Serum AKP, urine Ca, P and HOP were significantly increased.Conclusion\ Reduced BGP of OVX rat suggests that there is reduced bone formation and declined bone turnover during a slow phase of bone loss in ovariectomized rat.\;展开更多
文摘目的:探讨超声引导下细针穿刺活检(ultrasound guided fine needle aspiration biopsy,US-FNAB)对甲状腺结节的诊断价值。方法:回顾性分析天津医科大学总医院2016年1月至2017年4月行US-FNAB检查的甲状腺结节患者的临床特点及细胞病理诊断结果,对细胞诊断结果和手术病理结果进行对照分析。结果:在1 241例病例中,甲状腺结节男女比1:3.83(257/984),甲状腺结节的发病率从20岁开始逐年增加,60岁以后发病率开始下降。肿瘤最大径≤1.0 cm的结节640例(51.57%),TI-RADS 4级的结节1 072例(86.38%)。细胞学诊断结果中无法诊断的病例273例(22.00%),良性121例(9.75%),意义不明确的细胞非典型病变380例(30.62%),可疑恶性399例(32.15%),恶性68例(5.48%)。其中在天津医科大学总医院行手术的302例患者中,US-FNAB细胞病理有明确诊断203例,无法诊断21例,意义不明确的细胞非典型病变78例。203例明确诊断的病例中,US-FNAB诊断的灵敏度为100.00%(201/201),特异度为50.00%(1/2),阳性预测值99.50%(201/202),阴性预测值100.00%(1/1),诊断的准确率99.51%(202/203),误诊率0.49%(1/203)。在细胞学诊断为意义不明确的细胞非典型病变的78例中,恶性率70.51%。意义不明确细胞非典型病变是否为恶性与患者的年龄、性别、肿瘤大小和部位均无关(均P>0.05),与甲状腺超声影像报告和数据系统(thyroid imaging reporting and data system,TI-RADS)分级有关(P<0.05)。结论:US-FNAB对甲状腺结节有较高的诊断价值,值得推广应用,可以考虑部分代替术中冰冻,减少术中等候时间和患者的经济负担。
文摘Objective\ \ To measure the level of osteocalcin (BGP) in ovariectomized rat and study its significance. Methods\ 20 female SD inbred rats were divided into sham ovariectomized (sham OVX) group and ovariectomized group (OVX). 18 weeks postsurgery, serum and 24 hour urine were collected to measure BGP by radioimmunoassay. Serum Ca, P concentration, alkaline phosphatase activity, urine Ca, P and hydroxyproline were also measured. Results \ Compared with sham OVX rat, the BGP level of OVX rats (0 98±0 14μg/L)was markdly lower than that of sham OVX rat (1 50±0 32μg/L, P<0 01),and serum Ca, P were also reduced. Serum AKP, urine Ca, P and HOP were significantly increased.Conclusion\ Reduced BGP of OVX rat suggests that there is reduced bone formation and declined bone turnover during a slow phase of bone loss in ovariectomized rat.\;
