p-Chlorophenylhydrazine hydrochloride was synthesized from p-chloroaniline through diazotization followed by Na 2SO 3 reduction. The p-chloroaniline is at first diazotized in dilute hydrochloride acid and PEG-600, and...p-Chlorophenylhydrazine hydrochloride was synthesized from p-chloroaniline through diazotization followed by Na 2SO 3 reduction. The p-chloroaniline is at first diazotized in dilute hydrochloride acid and PEG-600, and then the solution of diazonium hydrochloride was reduced by droping into Na 2SO 3 solution at 70 ℃, and acided in 20%～25% of hydrochloride acid. The yield was above 84 5%(with purity≥99 5% by HPLC). The following reagent ratios were used in synthesis: n(p-chlorlaniline) ∶n(sodium nitrite)∶n(hydrochloride acid)∶n(sodium sulfite)=1 0∶ 1 02∶ 3 0∶ 2 5.展开更多
文摘p-Chlorophenylhydrazine hydrochloride was synthesized from p-chloroaniline through diazotization followed by Na 2SO 3 reduction. The p-chloroaniline is at first diazotized in dilute hydrochloride acid and PEG-600, and then the solution of diazonium hydrochloride was reduced by droping into Na 2SO 3 solution at 70 ℃, and acided in 20%～25% of hydrochloride acid. The yield was above 84 5%(with purity≥99 5% by HPLC). The following reagent ratios were used in synthesis: n(p-chlorlaniline) ∶n(sodium nitrite)∶n(hydrochloride acid)∶n(sodium sulfite)=1 0∶ 1 02∶ 3 0∶ 2 5.
