目的搭建基于循证医学理念的病友网络,帮助患者获取证据,促进患者参与循证实践,增进患者间的沟通互动。方法综合分析各类主流的循证网络资源Best Practice、Dyna Med Plus、Up To Date、Trip Database、Cochrane Library、NICE、NGC,探...目的搭建基于循证医学理念的病友网络,帮助患者获取证据,促进患者参与循证实践,增进患者间的沟通互动。方法综合分析各类主流的循证网络资源Best Practice、Dyna Med Plus、Up To Date、Trip Database、Cochrane Library、NICE、NGC,探讨其证据呈递形式。结合患者认知能力和信息需求,设计病友网络的证据查询和患者在线社区等功能模块。基于当前成熟的Web系统开发技术实现网络。结果本研究提出了将循证医学理念应用于病友网络的构想,设计了以患者为中心的证据呈递形式和患者沟通工具,开发了由循证医学、医疗查证、病友社区和健康管理4个功能模块组成的病友网络系统。结论基于循证医学理念的病友网络有利于拓展患者的循证知识,帮助患者快速获取高质量的干预措施证据,社交功能有助于增进人文关怀,患者健康数据的收集为开展患者报告结局的研究提供了基础。展开更多
Objective To observe value of 0D-1D coupling model and 3D fluid-structure interaction(FSI)model based on coronary CT angiography(CCTA)for displaying hemodynamic characteristics of coronary artery stenosis.Methods Base...Objective To observe value of 0D-1D coupling model and 3D fluid-structure interaction(FSI)model based on coronary CT angiography(CCTA)for displaying hemodynamic characteristics of coronary artery stenosis.Methods Based on CCTA data of the stenosed left anterior descending branch(LAD)in a patient with coronary heart disease,an 0D-1D coupling model and 3D FSI model were built,respectively.Then hemodynamic characteristic indexes,including the pressure,flow velocity and wall shear stress(WSS)were obtained in every 0.01 s during 1 s at 5 sampling points(i.e.sampling point 1—5)using these 2 models,respectively,and the consistencies of the results between models were evaluated with Spearman correlation coefficient r s.Results The time consuming for construction of 0D-1D coupling model and 3D FSI model was 0.033 min and 704 min,respectively.Both models showed basically distribution of the pressure,flow velocity and WSS of the stenosed LAD.For more details,the pressure at the stenosed segment of LAD and the proximal segment of stenosis were both higher,which gradually decreased at the distal segment of stenosis,and the flow velocity at the proximal segment of stenosis was in a relatively slow and uniform condition,with significantly increased flow velocity and WSS at the stenosed segment.Compared with 3D FSI model,0D-1D vascular coupling model was relatively unrefined and lack of distal flow lines when displaying blood flow velocity.For sampling point 2 at the stenosed segment of LAD,no significant consistency for pressure between 2 models was found(P=0.118),but strong consistency for the flow velocity and WSS(r s=0.730,0.807,both P<0.05).The consistencies of pressure,flow velocity and WSS between 2 models at the proximal and distal segment of stenosis,i.e.1,3—5 sampling points were week to moderate(r s=0.237—0.669,all P<0.05).Conclusion 0D-1D coupling model exhibited outstanding computational efficiency and might provide relatively reasonable results,while 3D FSI model showed higher accuracy for details and streamline when simulating LAD stenosis.展开更多
文摘目的搭建基于循证医学理念的病友网络,帮助患者获取证据,促进患者参与循证实践,增进患者间的沟通互动。方法综合分析各类主流的循证网络资源Best Practice、Dyna Med Plus、Up To Date、Trip Database、Cochrane Library、NICE、NGC,探讨其证据呈递形式。结合患者认知能力和信息需求,设计病友网络的证据查询和患者在线社区等功能模块。基于当前成熟的Web系统开发技术实现网络。结果本研究提出了将循证医学理念应用于病友网络的构想,设计了以患者为中心的证据呈递形式和患者沟通工具,开发了由循证医学、医疗查证、病友社区和健康管理4个功能模块组成的病友网络系统。结论基于循证医学理念的病友网络有利于拓展患者的循证知识,帮助患者快速获取高质量的干预措施证据,社交功能有助于增进人文关怀,患者健康数据的收集为开展患者报告结局的研究提供了基础。
文摘Objective To observe value of 0D-1D coupling model and 3D fluid-structure interaction(FSI)model based on coronary CT angiography(CCTA)for displaying hemodynamic characteristics of coronary artery stenosis.Methods Based on CCTA data of the stenosed left anterior descending branch(LAD)in a patient with coronary heart disease,an 0D-1D coupling model and 3D FSI model were built,respectively.Then hemodynamic characteristic indexes,including the pressure,flow velocity and wall shear stress(WSS)were obtained in every 0.01 s during 1 s at 5 sampling points(i.e.sampling point 1—5)using these 2 models,respectively,and the consistencies of the results between models were evaluated with Spearman correlation coefficient r s.Results The time consuming for construction of 0D-1D coupling model and 3D FSI model was 0.033 min and 704 min,respectively.Both models showed basically distribution of the pressure,flow velocity and WSS of the stenosed LAD.For more details,the pressure at the stenosed segment of LAD and the proximal segment of stenosis were both higher,which gradually decreased at the distal segment of stenosis,and the flow velocity at the proximal segment of stenosis was in a relatively slow and uniform condition,with significantly increased flow velocity and WSS at the stenosed segment.Compared with 3D FSI model,0D-1D vascular coupling model was relatively unrefined and lack of distal flow lines when displaying blood flow velocity.For sampling point 2 at the stenosed segment of LAD,no significant consistency for pressure between 2 models was found(P=0.118),but strong consistency for the flow velocity and WSS(r s=0.730,0.807,both P<0.05).The consistencies of pressure,flow velocity and WSS between 2 models at the proximal and distal segment of stenosis,i.e.1,3—5 sampling points were week to moderate(r s=0.237—0.669,all P<0.05).Conclusion 0D-1D coupling model exhibited outstanding computational efficiency and might provide relatively reasonable results,while 3D FSI model showed higher accuracy for details and streamline when simulating LAD stenosis.
