Chitosan derivative with glycyrrhetinic acid(GA),which was accumulated specifically in liver,was synthesized.By ion-crosslinking of TPP in GA-CTS solution,GA-CTS-TPP complex nanoparticles were obtained.The physicochem...Chitosan derivative with glycyrrhetinic acid(GA),which was accumulated specifically in liver,was synthesized.By ion-crosslinking of TPP in GA-CTS solution,GA-CTS-TPP complex nanoparticles were obtained.The physicochemical properties of these nanoparticles were investigated by using TEM and DLS.The experiment in vitro BSA entrapped was studied.GA-CTS-TPP nanoparticles are well dispersed and stable in aqueous solution in 14 months.展开更多
A new copolymer(C) was designed and synthesized.Isothermal Titration Calorimetry(ITC) expe-riments showed the strong binding of C-Zn and the predetermined peptide sequences(DFLAE,appear in many peptides sequence which...A new copolymer(C) was designed and synthesized.Isothermal Titration Calorimetry(ITC) expe-riments showed the strong binding of C-Zn and the predetermined peptide sequences(DFLAE,appear in many peptides sequence which cumulate in serum of uremic patients).The further ITC experiments demonstrate that the binding is the result of the cooperative effect of coordination and hydrophobic interaction,which may provide further understanding on the mechanism of polymer-metal-peptide interaction and a structural basis for designing the adsorbents for the target peptide.展开更多
文摘Chitosan derivative with glycyrrhetinic acid(GA),which was accumulated specifically in liver,was synthesized.By ion-crosslinking of TPP in GA-CTS solution,GA-CTS-TPP complex nanoparticles were obtained.The physicochemical properties of these nanoparticles were investigated by using TEM and DLS.The experiment in vitro BSA entrapped was studied.GA-CTS-TPP nanoparticles are well dispersed and stable in aqueous solution in 14 months.
文摘A new copolymer(C) was designed and synthesized.Isothermal Titration Calorimetry(ITC) expe-riments showed the strong binding of C-Zn and the predetermined peptide sequences(DFLAE,appear in many peptides sequence which cumulate in serum of uremic patients).The further ITC experiments demonstrate that the binding is the result of the cooperative effect of coordination and hydrophobic interaction,which may provide further understanding on the mechanism of polymer-metal-peptide interaction and a structural basis for designing the adsorbents for the target peptide.
