To evaluate the safety of oral cabamazepine during breast milk feeding.The carbamazepine concentration in breast milk of one epilepsy maternal patient was assayed by high performance liquid chromatography,and the lite...To evaluate the safety of oral cabamazepine during breast milk feeding.The carbamazepine concentration in breast milk of one epilepsy maternal patient was assayed by high performance liquid chromatography,and the literature was reviewed to find the nursing evidence in the use of cabamazepine.The carbamazepine concentration in breast milk ranged from 0.34-0.86 mg/L.The neonate daily dose intake was estimated ranging from 0.34 mg to 0.86 mg through breast-feeding in theory.The literature showed that carbamazepine was generally considered safe for use during breast feeding;however,adverse effects should be monitored as recommended.It is better to avoid feeding at high concentration level to minimize the harm of carbamazepine to the baby.展开更多
目的:探讨在有无肾功能损伤的情况下,合并用药及其他因素对地高辛血药浓度(serum Digoxin concentration,SDC)的影响,促进合理用药。方法:回顾性分析了北京大学第一医院2014年口服地高辛治疗并进行治疗药物监测(therapeutic drug monito...目的:探讨在有无肾功能损伤的情况下,合并用药及其他因素对地高辛血药浓度(serum Digoxin concentration,SDC)的影响,促进合理用药。方法:回顾性分析了北京大学第一医院2014年口服地高辛治疗并进行治疗药物监测(therapeutic drug monitoring,TDM)住院患者的病历。结果:55例肾功能基本正常的患者口服地高辛、合并使用抗菌药及噻嗪类利尿剂时对SDC影响较大;78例肾功能受损的患者口服地高辛、合并使用抗凝剂时对SDC影响较大;其他因素,如年龄对地高辛的代谢也有显著影响。结论:在有无肾功能损伤的情况下,合并用药均会影响SDC,为确保地高辛使用的安全性,监测其血药浓度意义重大。展开更多
文摘To evaluate the safety of oral cabamazepine during breast milk feeding.The carbamazepine concentration in breast milk of one epilepsy maternal patient was assayed by high performance liquid chromatography,and the literature was reviewed to find the nursing evidence in the use of cabamazepine.The carbamazepine concentration in breast milk ranged from 0.34-0.86 mg/L.The neonate daily dose intake was estimated ranging from 0.34 mg to 0.86 mg through breast-feeding in theory.The literature showed that carbamazepine was generally considered safe for use during breast feeding;however,adverse effects should be monitored as recommended.It is better to avoid feeding at high concentration level to minimize the harm of carbamazepine to the baby.
文摘目的:探讨在有无肾功能损伤的情况下,合并用药及其他因素对地高辛血药浓度(serum Digoxin concentration,SDC)的影响,促进合理用药。方法:回顾性分析了北京大学第一医院2014年口服地高辛治疗并进行治疗药物监测(therapeutic drug monitoring,TDM)住院患者的病历。结果:55例肾功能基本正常的患者口服地高辛、合并使用抗菌药及噻嗪类利尿剂时对SDC影响较大;78例肾功能受损的患者口服地高辛、合并使用抗凝剂时对SDC影响较大;其他因素,如年龄对地高辛的代谢也有显著影响。结论:在有无肾功能损伤的情况下,合并用药均会影响SDC,为确保地高辛使用的安全性,监测其血药浓度意义重大。
