Tubulointerstitial lesions, occurring in many kinds of renal diseases, have been found to be the predominant factor in the impairment of renal function. The severe and extensive lesions often predict a poor outcome in...Tubulointerstitial lesions, occurring in many kinds of renal diseases, have been found to be the predominant factor in the impairment of renal function. The severe and extensive lesions often predict a poor outcome in future. It has been tested recent years that the infiltrating inflammatory cells might play important roles in the onset and deterioration of tubulointerstitial injuries. On the other hand, the resident cells, including the tubular epithelial cells and the fibroblasts, also directly take part in tubulointerstitial inflammation and fibrosis. Researches also display implicated interactions between the infiltrating cells and the resident cells, which contribute to the amplification of inflammation and the progress of fibrosis.展开更多
Increasing evidence has proved that phenotypic changes occured in residential renal cells during the process of renal diseases. The phenotypic change of mesangial cell plays a key role in the development of glomerular...Increasing evidence has proved that phenotypic changes occured in residential renal cells during the process of renal diseases. The phenotypic change of mesangial cell plays a key role in the development of glomerular sclerosis, while the phenotypic changes of tubulo-interstitial cells have close relationship with the progress of interstitial fibrosis. Understandings of these phenotypic changes and their regulations may help us know better of the mechanism of renal diseases and find out ways to block the disease development.展开更多
Macrophages have been identified to play an important role in acute and chronic renal injury through exerting multiple biological effects.This review focus on the origin of macrophages in kidney, mechanism of renal in...Macrophages have been identified to play an important role in acute and chronic renal injury through exerting multiple biological effects.This review focus on the origin of macrophages in kidney, mechanism of renal injury and strategy of inhibiting macrophage infiltration. [展开更多
Serum creatinine and urine output is not sensitive for early detection and degree evaluation of acute kidney injury(AKI).Recently,triggered by high-throughput genomics and proteomics,identification of disease-related ...Serum creatinine and urine output is not sensitive for early detection and degree evaluation of acute kidney injury(AKI).Recently,triggered by high-throughput genomics and proteomics,identification of disease-related proteins has been revolutionized.The proposed biomarkers of AKI,such as kidney injury molecule(KIM-1),neutrophil gelatinase associated lipocalin(NGAL),interleukin-18(IL-18),sodium/hydrogen exchanger isoform 3(NHE3),spermidine/spermine acetyltransferase(SAT),and so on,are involved in various pathological processes,including immunity,cell structure,cell-cycle and signal transduction.More clinical and experimental investigations are needed to identify more biomarkers which are useful for early diagnosis of AKI.展开更多
文摘Tubulointerstitial lesions, occurring in many kinds of renal diseases, have been found to be the predominant factor in the impairment of renal function. The severe and extensive lesions often predict a poor outcome in future. It has been tested recent years that the infiltrating inflammatory cells might play important roles in the onset and deterioration of tubulointerstitial injuries. On the other hand, the resident cells, including the tubular epithelial cells and the fibroblasts, also directly take part in tubulointerstitial inflammation and fibrosis. Researches also display implicated interactions between the infiltrating cells and the resident cells, which contribute to the amplification of inflammation and the progress of fibrosis.
文摘Increasing evidence has proved that phenotypic changes occured in residential renal cells during the process of renal diseases. The phenotypic change of mesangial cell plays a key role in the development of glomerular sclerosis, while the phenotypic changes of tubulo-interstitial cells have close relationship with the progress of interstitial fibrosis. Understandings of these phenotypic changes and their regulations may help us know better of the mechanism of renal diseases and find out ways to block the disease development.
文摘Macrophages have been identified to play an important role in acute and chronic renal injury through exerting multiple biological effects.This review focus on the origin of macrophages in kidney, mechanism of renal injury and strategy of inhibiting macrophage infiltration. [
文摘Serum creatinine and urine output is not sensitive for early detection and degree evaluation of acute kidney injury(AKI).Recently,triggered by high-throughput genomics and proteomics,identification of disease-related proteins has been revolutionized.The proposed biomarkers of AKI,such as kidney injury molecule(KIM-1),neutrophil gelatinase associated lipocalin(NGAL),interleukin-18(IL-18),sodium/hydrogen exchanger isoform 3(NHE3),spermidine/spermine acetyltransferase(SAT),and so on,are involved in various pathological processes,including immunity,cell structure,cell-cycle and signal transduction.More clinical and experimental investigations are needed to identify more biomarkers which are useful for early diagnosis of AKI.
