Connective tissue growth factor (CTGF) has recently received much attention as a possible key determinant of progressive fibrosis. It promotes tissue fibrosis through different pathways, such as cell proliferation, ex...Connective tissue growth factor (CTGF) has recently received much attention as a possible key determinant of progressive fibrosis. It promotes tissue fibrosis through different pathways, such as cell proliferation, extracellular matrix accumulation and cell transdifferentiation. A number of regulators of CTGF expression have been identified, including transforming growth factor β, vascular endothelial growth factor, tumor necrosis factor α, etc. The mechanism of profibrotic effect by CTGF was reviewed. [展开更多
Increase in peritoneal membrane permeabil ity is not uncommon in long-t erm peritoneal dialysis patients. It has been shown that increased peritoneal me mbrane permeability is associated with increased mortality in th...Increase in peritoneal membrane permeabil ity is not uncommon in long-t erm peritoneal dialysis patients. It has been shown that increased peritoneal me mbrane permeability is associated with increased mortality in this patient popul ation. We have been thus focused on the pathogenesis of the abnormal peritoneal membrane permeability. It was hypothesized that increased membrane permeability might be due to (1)neoangiogenesis; (2)chronic inflammation; (3)increased hydrau lic permeability of the peritoneal membrane. We have, however, found that increa se d membrane hydraulic permeability may be the key mechanism. We found that the pe ritoneal surface layer, the key component that determines the tissue hydraulic p ermeability, was rich in hyaluronan, phospholipids and surfactant proteins. Dama ging the peritoneal surface layer by shaking the peritoneal cavity, washing, add ing pentobarbital or deoxycholic acid or hyaluronidase or phospholipidase, we ha ve sig nificantly increased the membrane permeability. On the contrary, by adding hyalu r onan, phospholipids or steroid to increase the formation of the peritoneal surfa ce layer, we have decreased significantly the peritoneal permeability. Our resea rch work on this issue has been well recognized and appreciated by the interna tional society.展开更多
文摘Connective tissue growth factor (CTGF) has recently received much attention as a possible key determinant of progressive fibrosis. It promotes tissue fibrosis through different pathways, such as cell proliferation, extracellular matrix accumulation and cell transdifferentiation. A number of regulators of CTGF expression have been identified, including transforming growth factor β, vascular endothelial growth factor, tumor necrosis factor α, etc. The mechanism of profibrotic effect by CTGF was reviewed. [
文摘Increase in peritoneal membrane permeabil ity is not uncommon in long-t erm peritoneal dialysis patients. It has been shown that increased peritoneal me mbrane permeability is associated with increased mortality in this patient popul ation. We have been thus focused on the pathogenesis of the abnormal peritoneal membrane permeability. It was hypothesized that increased membrane permeability might be due to (1)neoangiogenesis; (2)chronic inflammation; (3)increased hydrau lic permeability of the peritoneal membrane. We have, however, found that increa se d membrane hydraulic permeability may be the key mechanism. We found that the pe ritoneal surface layer, the key component that determines the tissue hydraulic p ermeability, was rich in hyaluronan, phospholipids and surfactant proteins. Dama ging the peritoneal surface layer by shaking the peritoneal cavity, washing, add ing pentobarbital or deoxycholic acid or hyaluronidase or phospholipidase, we ha ve sig nificantly increased the membrane permeability. On the contrary, by adding hyalu r onan, phospholipids or steroid to increase the formation of the peritoneal surfa ce layer, we have decreased significantly the peritoneal permeability. Our resea rch work on this issue has been well recognized and appreciated by the interna tional society.
