SUMMARY Mucosal malignant melanoma of the nasal cavity and paranasal sinuses are rare. Because symptoms and radiological examinations of this disease are generally nonspecific, the diagnosis is often difficult. Diagno...SUMMARY Mucosal malignant melanoma of the nasal cavity and paranasal sinuses are rare. Because symptoms and radiological examinations of this disease are generally nonspecific, the diagnosis is often difficult. Diagnosis can be confirmed by the immunohistochemical profile of staining with HMB-45 and S-100. This study deals with two cases of nonspecific clinical features. The factors of misdiagnosis were discussed and the lesson was summarized.展开更多
SUMMARY Wegener’s granulomatosisis (WG) is a multi-system disease characterized by granuloma formation and necrotizing vasciculitis. It typically involves the upper and lower respiratory tract and kidney. Otologic in...SUMMARY Wegener’s granulomatosisis (WG) is a multi-system disease characterized by granuloma formation and necrotizing vasciculitis. It typically involves the upper and lower respiratory tract and kidney. Otologic involvement may occasionally be the initial symptom of WG. A case report of WG was described, which first presented as facial nerve palsy. The combination of facial nerve palsy, sensorineural hearing loss and otitis media was unusual. We should raise suspicion. Early diagnosis is vital if unnecessary surgical exploration is to be avoided. The diagnosis of a WG is made clinically based on clinical findings, histologic confirmation and titres of cytoplasmic pattern antineutrophil cytoplasmic autoantibodies (c-ANCA)/ Anti-proteinase 3 (Anti-PR3). Immunosuppressive therapy with steroids, cyclophosphamide (CTX) is required for relief. A delay in diagnosis may lead to devastating sequelae, such as facial nerve palsy and hearing loss. WG is a challenging disease for otorhinolaryngologist.展开更多
文摘SUMMARY Mucosal malignant melanoma of the nasal cavity and paranasal sinuses are rare. Because symptoms and radiological examinations of this disease are generally nonspecific, the diagnosis is often difficult. Diagnosis can be confirmed by the immunohistochemical profile of staining with HMB-45 and S-100. This study deals with two cases of nonspecific clinical features. The factors of misdiagnosis were discussed and the lesson was summarized.
文摘SUMMARY Wegener’s granulomatosisis (WG) is a multi-system disease characterized by granuloma formation and necrotizing vasciculitis. It typically involves the upper and lower respiratory tract and kidney. Otologic involvement may occasionally be the initial symptom of WG. A case report of WG was described, which first presented as facial nerve palsy. The combination of facial nerve palsy, sensorineural hearing loss and otitis media was unusual. We should raise suspicion. Early diagnosis is vital if unnecessary surgical exploration is to be avoided. The diagnosis of a WG is made clinically based on clinical findings, histologic confirmation and titres of cytoplasmic pattern antineutrophil cytoplasmic autoantibodies (c-ANCA)/ Anti-proteinase 3 (Anti-PR3). Immunosuppressive therapy with steroids, cyclophosphamide (CTX) is required for relief. A delay in diagnosis may lead to devastating sequelae, such as facial nerve palsy and hearing loss. WG is a challenging disease for otorhinolaryngologist.
