ATP-sensitive potassium channel(KATP) consists of a 4.4 complex of an inwardly rectifying Kir6.x pore plus a sulfonylurea receptor,which is an ATP-binding cassette transporter.KATP has been indentified in a variety of...ATP-sensitive potassium channel(KATP) consists of a 4.4 complex of an inwardly rectifying Kir6.x pore plus a sulfonylurea receptor,which is an ATP-binding cassette transporter.KATP has been indentified in a variety of tissues and recognized as an important drug target.It connects cell metabolism with cell electric activity.KATP has been proposed to play protective roles during heart failure,arrhythmia,myocardial infarction,stress,myocardial ischemia and hypertension.In this review,a summary of KATP is presented with molecular structure,localization,regulation,cardiovascular protective effect and its mechanisms.展开更多
目的:分析体位性心动过速综合征(postural tachycardia syndrome, POTS)儿童及青少年直立试验过程中血流动力学变化及不同心脏指数(cardiac index, CI)患者血流动力学指标的差异。方法:回顾性分析26例POTS患者与12例健康对照者间直立试...目的:分析体位性心动过速综合征(postural tachycardia syndrome, POTS)儿童及青少年直立试验过程中血流动力学变化及不同心脏指数(cardiac index, CI)患者血流动力学指标的差异。方法:回顾性分析26例POTS患者与12例健康对照者间直立试验过程中总外周血管阻力指数(total peripheral vascular resistance index, TPVRI)、心率和血压的变化,并比较两组间各指标变化趋势。根据每位POTS患者直立试验过程中CI变化趋势将患者分为CI降低组(14例)与CI未降低组(12例),分析两组患者在直立试验过程中CI、TPVRI、心率、血压变化,并比较两组间各指标变化趋势。结果: POTS患者在直立试验过程中CI显著下降( F =6.936, P =0.001),心率明显增快( F = 113.926 , P <0.001),收缩压明显降低( F =6.049, P <0.001),而TPVRI ( F =2.031, P =0.138)和舒张压( F =2.018, P =0.113)无明显变化。健康对照组CI在直立后显著升高( F =3.646, P =0.016),同时心率明显增快( F = 43.970, P <0.001),收缩压( F =4.043, P =0.020)和舒张压( F =8.627, P <0.001)均明显升高,TPVRI ( F = 1.688, P =0.190)无明显变化。POTS患者与健康对照组比较,CI ( F =6.221, P= 0.001)、心率( F =6.203, P < 0.001)和收缩压( F =7.946, P <0.001)随时间变化趋势显著不同,而TPVRI和舒张压在两组间的变化趋势差异无统计学意义( P >0.05)。CI降低组与CI未降低组POTS患者在直立试验中CI变化趋势差异有统计学意义( F = 14.723, P <0.001),前者直立后收缩压明显降低( F =8.010, P <0.001),而后者却无明显变化( F =0.612, P = 0.639 ), TPVRI、心率和舒张压在CI降低组与CI未降低组间随时间变化趋势差异无统计学意义( P >0.05)。年龄是POTS患者直立后CI呈下降趋势的独立影响因素( P =0.013, OR =2.233;95% CI :1.183~4.216)。结论: POTS患者在直立试验过程中存在明显的血流动力学变化,不同患者心输出量变化可能不同,年龄是心输出量下降的独立影响因素。展开更多
文摘ATP-sensitive potassium channel(KATP) consists of a 4.4 complex of an inwardly rectifying Kir6.x pore plus a sulfonylurea receptor,which is an ATP-binding cassette transporter.KATP has been indentified in a variety of tissues and recognized as an important drug target.It connects cell metabolism with cell electric activity.KATP has been proposed to play protective roles during heart failure,arrhythmia,myocardial infarction,stress,myocardial ischemia and hypertension.In this review,a summary of KATP is presented with molecular structure,localization,regulation,cardiovascular protective effect and its mechanisms.
文摘目的:分析体位性心动过速综合征(postural tachycardia syndrome, POTS)儿童及青少年直立试验过程中血流动力学变化及不同心脏指数(cardiac index, CI)患者血流动力学指标的差异。方法:回顾性分析26例POTS患者与12例健康对照者间直立试验过程中总外周血管阻力指数(total peripheral vascular resistance index, TPVRI)、心率和血压的变化,并比较两组间各指标变化趋势。根据每位POTS患者直立试验过程中CI变化趋势将患者分为CI降低组(14例)与CI未降低组(12例),分析两组患者在直立试验过程中CI、TPVRI、心率、血压变化,并比较两组间各指标变化趋势。结果: POTS患者在直立试验过程中CI显著下降( F =6.936, P =0.001),心率明显增快( F = 113.926 , P <0.001),收缩压明显降低( F =6.049, P <0.001),而TPVRI ( F =2.031, P =0.138)和舒张压( F =2.018, P =0.113)无明显变化。健康对照组CI在直立后显著升高( F =3.646, P =0.016),同时心率明显增快( F = 43.970, P <0.001),收缩压( F =4.043, P =0.020)和舒张压( F =8.627, P <0.001)均明显升高,TPVRI ( F = 1.688, P =0.190)无明显变化。POTS患者与健康对照组比较,CI ( F =6.221, P= 0.001)、心率( F =6.203, P < 0.001)和收缩压( F =7.946, P <0.001)随时间变化趋势显著不同,而TPVRI和舒张压在两组间的变化趋势差异无统计学意义( P >0.05)。CI降低组与CI未降低组POTS患者在直立试验中CI变化趋势差异有统计学意义( F = 14.723, P <0.001),前者直立后收缩压明显降低( F =8.010, P <0.001),而后者却无明显变化( F =0.612, P = 0.639 ), TPVRI、心率和舒张压在CI降低组与CI未降低组间随时间变化趋势差异无统计学意义( P >0.05)。年龄是POTS患者直立后CI呈下降趋势的独立影响因素( P =0.013, OR =2.233;95% CI :1.183~4.216)。结论: POTS患者在直立试验过程中存在明显的血流动力学变化,不同患者心输出量变化可能不同,年龄是心输出量下降的独立影响因素。
