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Research progresses of dual-layer spectral detector CT for preoperative evaluation on colorectal cancer 被引量:3
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作者 LI Pengqiang LIU Nianjun +5 位作者 ZHANG Yanli WANG Yanfei LAN Jinhui REN Huling DOU Yu LEI Junqiang 《中国医学影像技术》 CSCD 北大核心 2024年第8期1262-1265,共4页
Dual-layer spectral detector CT is a new spectrum CT imaging technology based on detector being able to obtain both images similar to true plain and spectral images in one time scanning.The reconstructed multi-paramet... Dual-layer spectral detector CT is a new spectrum CT imaging technology based on detector being able to obtain both images similar to true plain and spectral images in one time scanning.The reconstructed multi-parameter spectral images can not only improve image quality,enhance tissue contrast,increase the visualization and detection ability of occult lesions,but also provide qualitative and quantitative analysis of the lesions,so as to provide more imaging information and multi-dimensional diagnostic basis.The research progresses of dual-layer spectral detector CT for preoperative evaluation on colorectal cancer were reviewed in this article. 展开更多
关键词 colorectal neoplasms tomography X-ray computed
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CNPY2增强非小细胞肺癌细胞上皮-间质转化作用 被引量:1
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作者 窦郁 马娴 余勤 《临床与实验病理学杂志》 CAS CSCD 北大核心 2019年第10期1199-1203,共5页
目的探讨CNPY2激活AKT/GSK3β途径增强非小细胞肺癌(non-small cell lung cancer,NSCLC)细胞侵袭和迁移作用的机制。方法采用qRT-PCR和Western blot法检测AKT/GSK3β途径在CNPY2诱导下上皮、间质标志物以及上皮细胞-间质转化(epithelial... 目的探讨CNPY2激活AKT/GSK3β途径增强非小细胞肺癌(non-small cell lung cancer,NSCLC)细胞侵袭和迁移作用的机制。方法采用qRT-PCR和Western blot法检测AKT/GSK3β途径在CNPY2诱导下上皮、间质标志物以及上皮细胞-间质转化(epithelial-mesenchymal transition,EMT)相关转录因子的表达变化。通过Transwell侵袭实验和细胞划痕修复实验观察过表达CNPY2对NSCLC细胞侵袭和迁移能力的影响。结果CNPY2和E-cadherin在mRNA水平的表达呈负相关。细胞划痕修复实验和Transwell侵袭实验表明CNPY2促进NSCLC细胞的侵袭和迁移能力。进一步分析发现CNPY2可以激活AKT/GSK3β途径,导致GSK3β失活,增加Snail的水平,进而降低E-cadherin的表达,促进细胞发生EMT。结论CNPY2促进NSCLC细胞的EMT过程,在NSCLC侵袭和迁移中发挥重要作用,CNPY2可作为治疗NSCLC的新型靶点。 展开更多
关键词 肺肿瘤 非小细胞肺癌 CNPY2 E-CADHERIN 上皮细胞-间质转化 SNAIL
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