Objective:Albumin-globulin ratio(AGR),prognostic nutritional index(PNI),and platelet to-lymphocyte ratio(PLR)have been validated as prognostic factors for gastric cancer(GC).However,significant gender differences exis...Objective:Albumin-globulin ratio(AGR),prognostic nutritional index(PNI),and platelet to-lymphocyte ratio(PLR)have been validated as prognostic factors for gastric cancer(GC).However,significant gender differences exist in albumin levels and inflammatory cell counts,and further research is required to understand how these differences influence GC prognosis.This study aims to investigate the prognostic impact of nutritional and inflammatory indicators on GC patients undergoing radical surgery,as well as the influence of gender on these indicators’prognostic value.Methods:The study included 596 patients with advanced GC hospitalized in the Department of Gastrointestinal Surgery,General Surgery,Xiangya Hospital of Central South University from January 2012 to December 2016.Receiver operating characteristic(ROC)analysis was performed to determine cutoff values for nutritional and inflammatory factors.Univariate analysis was used to identify factors significantly affecting survival in GC patients,while multivariate and Kaplan-Meier analyses determined independent prognostic factors for GC.Results:Multivariate analysis revealed that postsurgical tumor node metastasis(pTNM)stage[stage II:hazard ratio(HR)=3.284,P=0.012;stage III:HR:8.062,P<0.001],low preoperative AGR(HR=1.499,P=0.012),and postoperative PNI(HR=1.503,P=0.008)were risk factors for overall survival in male patients after radical GC surgery.For female patients,pN2-3(HR=3.185,P<0.001),total gastrectomy(HR=2.286,P=0.004),low preoperative PLR(HR=1.702,P=0.027),and postoperative PNI(HR=1.943,P=0.011)were identified as risk factors for overall survival.Conclusion:Postoperative PNI is an independent risk factor for all advanced GC patients.Preoperative PLR is an independent prognostic factor only for female patients,while preoperative AGR is an independent prognostic factor only for male patients.Further research is warranted to investigate the gender-specific differences in GC prognosis.展开更多
目的探讨胃癌患者支持性照顾需求现状,分析其影响因素。方法2018年10月至2019年3月,采用便利抽样法选取在中山大学肿瘤防治中心和中山大学附属第六医院门诊和肿瘤科的178例胃癌患者为研究对象。采用一般情况调查问卷、支持性照顾需求简...目的探讨胃癌患者支持性照顾需求现状,分析其影响因素。方法2018年10月至2019年3月,采用便利抽样法选取在中山大学肿瘤防治中心和中山大学附属第六医院门诊和肿瘤科的178例胃癌患者为研究对象。采用一般情况调查问卷、支持性照顾需求简明问卷(the supportive care needs survey-34-item short form,SCNS-SF34)、安德森症状评估量表胃肠道肿瘤特异性模块(the M.D.Anderson symptom inventory gastrointestinal cancer module,MDASI-GI)及恐惧疾病进展简化量表(fear of progression questionnaire short form,FoP-Q-SF)对其进行调查。结果178例胃癌患者的总体SCNS-SF34得分为(2.87±0.59)分。不同文化程度、肿瘤部位、临床分期、白蛋白数值的胃癌患者SCNS-SF34总分差异均有统计学意义(均P<0.05)。症状严重程度、症状困扰程度得分与胃癌患者SCNS-SF34总分相关,相关系数为0.743、0.777;FoP-Q-SF总分及生理健康维度、社会家庭维度得分与胃癌患者的支持性照顾需求得分相关,相关系数分别为0.818、0.817、0.739。文化程度、症状体验和恐惧疾病进展心理是胃癌患者的支持性照顾需求的主要影响因素。结论胃癌患者支持性照顾需求的满足情况不理想,应通过评估患者症状体验、恐惧疾病进展水平来制定个性化的护理方案以满足患者需求。展开更多
基金supported by the National Natural Science Foundation of China(8197103463).
文摘Objective:Albumin-globulin ratio(AGR),prognostic nutritional index(PNI),and platelet to-lymphocyte ratio(PLR)have been validated as prognostic factors for gastric cancer(GC).However,significant gender differences exist in albumin levels and inflammatory cell counts,and further research is required to understand how these differences influence GC prognosis.This study aims to investigate the prognostic impact of nutritional and inflammatory indicators on GC patients undergoing radical surgery,as well as the influence of gender on these indicators’prognostic value.Methods:The study included 596 patients with advanced GC hospitalized in the Department of Gastrointestinal Surgery,General Surgery,Xiangya Hospital of Central South University from January 2012 to December 2016.Receiver operating characteristic(ROC)analysis was performed to determine cutoff values for nutritional and inflammatory factors.Univariate analysis was used to identify factors significantly affecting survival in GC patients,while multivariate and Kaplan-Meier analyses determined independent prognostic factors for GC.Results:Multivariate analysis revealed that postsurgical tumor node metastasis(pTNM)stage[stage II:hazard ratio(HR)=3.284,P=0.012;stage III:HR:8.062,P<0.001],low preoperative AGR(HR=1.499,P=0.012),and postoperative PNI(HR=1.503,P=0.008)were risk factors for overall survival in male patients after radical GC surgery.For female patients,pN2-3(HR=3.185,P<0.001),total gastrectomy(HR=2.286,P=0.004),low preoperative PLR(HR=1.702,P=0.027),and postoperative PNI(HR=1.943,P=0.011)were identified as risk factors for overall survival.Conclusion:Postoperative PNI is an independent risk factor for all advanced GC patients.Preoperative PLR is an independent prognostic factor only for female patients,while preoperative AGR is an independent prognostic factor only for male patients.Further research is warranted to investigate the gender-specific differences in GC prognosis.
文摘目的探讨胃癌患者支持性照顾需求现状,分析其影响因素。方法2018年10月至2019年3月,采用便利抽样法选取在中山大学肿瘤防治中心和中山大学附属第六医院门诊和肿瘤科的178例胃癌患者为研究对象。采用一般情况调查问卷、支持性照顾需求简明问卷(the supportive care needs survey-34-item short form,SCNS-SF34)、安德森症状评估量表胃肠道肿瘤特异性模块(the M.D.Anderson symptom inventory gastrointestinal cancer module,MDASI-GI)及恐惧疾病进展简化量表(fear of progression questionnaire short form,FoP-Q-SF)对其进行调查。结果178例胃癌患者的总体SCNS-SF34得分为(2.87±0.59)分。不同文化程度、肿瘤部位、临床分期、白蛋白数值的胃癌患者SCNS-SF34总分差异均有统计学意义(均P<0.05)。症状严重程度、症状困扰程度得分与胃癌患者SCNS-SF34总分相关,相关系数为0.743、0.777;FoP-Q-SF总分及生理健康维度、社会家庭维度得分与胃癌患者的支持性照顾需求得分相关,相关系数分别为0.818、0.817、0.739。文化程度、症状体验和恐惧疾病进展心理是胃癌患者的支持性照顾需求的主要影响因素。结论胃癌患者支持性照顾需求的满足情况不理想,应通过评估患者症状体验、恐惧疾病进展水平来制定个性化的护理方案以满足患者需求。
