Inflammation plays a pivotal role in atherogenesis. In addition to being a potent predictive and prognostic marker for major cardiovascular events,recent evidence indicates that C-reactive protein (CRP) might directly...Inflammation plays a pivotal role in atherogenesis. In addition to being a potent predictive and prognostic marker for major cardiovascular events,recent evidence indicates that C-reactive protein (CRP) might directly promote atherogenesis by exerting direct effects on vascular cells. Thus,CRP will become important novel pharmaceutical targets for the treatment of atherosclerosis. This review presents an overview of the current knowledge about the pathological role of CRP in atherosclerosis initiation and progression.展开更多
心肌肥大是心肌细胞对外界刺激,如压力超负荷、神经体液因子等的应答反应。多种信号通路参与心肌肥大的过程,它的分子机制尚未完全清楚。丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)信号转导通路在细胞生长、分化、增...心肌肥大是心肌细胞对外界刺激,如压力超负荷、神经体液因子等的应答反应。多种信号通路参与心肌肥大的过程,它的分子机制尚未完全清楚。丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)信号转导通路在细胞生长、分化、增殖和凋亡等过程中起着重要作用,本文就MAPK主要信号通路在心肌肥大中的作用作一简要综述。展开更多
文摘Inflammation plays a pivotal role in atherogenesis. In addition to being a potent predictive and prognostic marker for major cardiovascular events,recent evidence indicates that C-reactive protein (CRP) might directly promote atherogenesis by exerting direct effects on vascular cells. Thus,CRP will become important novel pharmaceutical targets for the treatment of atherosclerosis. This review presents an overview of the current knowledge about the pathological role of CRP in atherosclerosis initiation and progression.
文摘心肌肥大是心肌细胞对外界刺激,如压力超负荷、神经体液因子等的应答反应。多种信号通路参与心肌肥大的过程,它的分子机制尚未完全清楚。丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)信号转导通路在细胞生长、分化、增殖和凋亡等过程中起着重要作用,本文就MAPK主要信号通路在心肌肥大中的作用作一简要综述。
