Stroke and Vascular Neurology(SVN)2019年6月上线文章“Neuroimaging studies on cognitive impairment due to cerebral small vessel disease”,由上海交通大学医学院附属仁济医院徐群、杜静完成。文章概述了脑小血管病(cerebral sm...Stroke and Vascular Neurology(SVN)2019年6月上线文章“Neuroimaging studies on cognitive impairment due to cerebral small vessel disease”,由上海交通大学医学院附属仁济医院徐群、杜静完成。文章概述了脑小血管病(cerebral small vessel disease,CSVD)及其导致的血管性认知障碍(vascular cognitive impairment,VCI),重点综述了目前对于脑小血管病导致认知障碍的神经影像学研究,并对仁济医院脑小血管病队列研究(Renji CSVD Cohort Study,RCCS)的工作进展进行了简要介绍。展开更多
Microglia activation induced neuroinflammation closely relates with the development of Parkinson disease. Autophagy regulates many biological processes,but the role in microglial activation and the development of Park...Microglia activation induced neuroinflammation closely relates with the development of Parkinson disease. Autophagy regulates many biological processes,but the role in microglial activation and the development of Parkinson disease is not clear. In this study,we show that loss of microglial Atg5 cause neuroinflammation and motor and cognitive learning impairment in mice,with accumulation of α-synuclein and decrease of dopamine levels in the striatum. Inhibition of autophagy aggravates the activation of NLRP3 inflammasome via PDE10a-cAMP signaling in microglia. Furthermore,the downstream cytokine IL-1 increases Mif levels in a transcriptional dependent manner. Interestingly,Mif levels are significantly elevated in Parkinson disease patients. Taken together,our results reveal a protective role of autophagy in microglial activation-driven Parkinson disease,thus providing a potential targets for the clinical treatment.展开更多
文摘Stroke and Vascular Neurology(SVN)2019年6月上线文章“Neuroimaging studies on cognitive impairment due to cerebral small vessel disease”,由上海交通大学医学院附属仁济医院徐群、杜静完成。文章概述了脑小血管病(cerebral small vessel disease,CSVD)及其导致的血管性认知障碍(vascular cognitive impairment,VCI),重点综述了目前对于脑小血管病导致认知障碍的神经影像学研究,并对仁济医院脑小血管病队列研究(Renji CSVD Cohort Study,RCCS)的工作进展进行了简要介绍。
文摘Microglia activation induced neuroinflammation closely relates with the development of Parkinson disease. Autophagy regulates many biological processes,but the role in microglial activation and the development of Parkinson disease is not clear. In this study,we show that loss of microglial Atg5 cause neuroinflammation and motor and cognitive learning impairment in mice,with accumulation of α-synuclein and decrease of dopamine levels in the striatum. Inhibition of autophagy aggravates the activation of NLRP3 inflammasome via PDE10a-cAMP signaling in microglia. Furthermore,the downstream cytokine IL-1 increases Mif levels in a transcriptional dependent manner. Interestingly,Mif levels are significantly elevated in Parkinson disease patients. Taken together,our results reveal a protective role of autophagy in microglial activation-driven Parkinson disease,thus providing a potential targets for the clinical treatment.
