AIM:To clarify both the character of the absorption and the stability of crocin in various sites along the intestinal tract,and also to determine the partition coefficient of crocin-1 in water/n-caprylic alcohol syste...AIM:To clarify both the character of the absorption and the stability of crocin in various sites along the intestinal tract,and also to determine the partition coefficient of crocin-1 in water/n-caprylic alcohol system. METHOD:The intestinal absorption and stability was investigated using in situ perfusion method in rats; Shaking flask test was used to determine the partition coefficient of crocin-1;Concentration of crocin-1 was detected by HPLC.RESULT:Decrease of Crocin-1 in various intestine segments is as follows:Duodenum 13.81%,Jejunum 9.89%,Ileum 10.07%,and Colon 10.04%,but crocin-1 can’t be found in blood; Degradation of Crocin-1 during incubation in refluxing solution of various intestinal segments is as follows:Duodenum 13.01%,Jejunum 10.11%,Ileum 9.95%,and Colon 10.45%; The partition coefficient of crocin-1 P =0.093±0.004,log P =-1.03±0.02.CONCLUSION:The results suggest that crocin is unstable and can’t be absorbed in the whole intestinal tract.展开更多
The Perfluoroalkylethyl acrylate copolymer, with an excellent property of waterproof and oilproof, was prepared by emulsion polymerization. The surface characterization of the copolymer was performed by surface free e...The Perfluoroalkylethyl acrylate copolymer, with an excellent property of waterproof and oilproof, was prepared by emulsion polymerization. The surface characterization of the copolymer was performed by surface free energy calculation and AES analysis. The calculated result of surface free energy was 0.012 6 J/m\+2, which is much lower than that of organosilicon polymer. It was found by AES that perfluoroalkyl groups for the outermost layer has a decisive effect on the surface free energy.展开更多
文摘AIM:To clarify both the character of the absorption and the stability of crocin in various sites along the intestinal tract,and also to determine the partition coefficient of crocin-1 in water/n-caprylic alcohol system. METHOD:The intestinal absorption and stability was investigated using in situ perfusion method in rats; Shaking flask test was used to determine the partition coefficient of crocin-1;Concentration of crocin-1 was detected by HPLC.RESULT:Decrease of Crocin-1 in various intestine segments is as follows:Duodenum 13.81%,Jejunum 9.89%,Ileum 10.07%,and Colon 10.04%,but crocin-1 can’t be found in blood; Degradation of Crocin-1 during incubation in refluxing solution of various intestinal segments is as follows:Duodenum 13.01%,Jejunum 10.11%,Ileum 9.95%,and Colon 10.45%; The partition coefficient of crocin-1 P =0.093±0.004,log P =-1.03±0.02.CONCLUSION:The results suggest that crocin is unstable and can’t be absorbed in the whole intestinal tract.
文摘The Perfluoroalkylethyl acrylate copolymer, with an excellent property of waterproof and oilproof, was prepared by emulsion polymerization. The surface characterization of the copolymer was performed by surface free energy calculation and AES analysis. The calculated result of surface free energy was 0.012 6 J/m\+2, which is much lower than that of organosilicon polymer. It was found by AES that perfluoroalkyl groups for the outermost layer has a decisive effect on the surface free energy.
