This study used non-invasive evaluation methods measured six skin physiological parameters of the lower lip in 180 subjects,including moisture content,transepidermal water loss(TEWL),smoothness(SESM),scaliness of the ...This study used non-invasive evaluation methods measured six skin physiological parameters of the lower lip in 180 subjects,including moisture content,transepidermal water loss(TEWL),smoothness(SESM),scaliness of the skin(SESC),wrinkles(SEW),and red area of the lip skin,and compared the effects of 6 groups of lip balms(no-additive group,marine oligosaccharides group,ceramides group,glycyrrhizinic acid group,allantoin group,and mixed group;30 each)on the skin physiological parameters of dry,flaking,and cracked lip subjects.The results showed that the lip mositure content of the subjects in the marine oligosaccharide group,glycyrrhetinic acid group,and allantoin group increased significantly by 44.40%,42.84%and 58.08%after 7 days of lip balm(P<0.05).The TEWL in the ceramide group and the allantoin group was significantly reduced by 21.83%and 24.72%,respectively,after 7 days of lip paste use(P<0.05).The lip skin smoothness values of subjects in the glycyrrhizic acid group and the allantoin group were significantly reduced by 18.76%and 14.97%,respectively,after 28 days of lip balm application(P<0.05).The lip skin scaling indices of subjects in the marine oligosaccharide group,the ceramides group,and the allantoin group were significantly reduced by 33.77%,42.69%,and 38.07%,respectively,after 28 days of lip balm application(P<0.05).The wrinkle parameters of the lip skin of the subjects in the marine oligosaccharide,glycyrrhizinic acid and allantoin groups were significantly reduced by 23.06%,23.29%and 25.98%,respectively,after 28 days of lip balm application(P<0.05).And the area of the red zone of the lip skin of the subjects in the allantoin group was significantly reduced by 4.27%,after 28 days of lip balm application(P<0.05).Combining the effects of the four active ingredients on the secretion of hyaluronic acid(moisturizing effect)and inflammatory factor(IL-6)in HSF cells,it suggests that marine oligosaccharides and allantoin have a perfect impact on enhancing the water content of the skin on the lips of the subjects,and further improve the symptoms of flaking and wrinkles on the lips of the subjects.The ceramide and allantoin can repair the skin barrier well and have a good effect on the chapped and flaky lips of the subjects.After 28 days of using lip balm,the water content of lips in the mixed group increased,the skin barrier was repaired and became smoother,and the wrinkles,scale index,and red zone value were reduced,which could well relieve chronic lip inflammation and lay a foundation for developing lip products for the treatment of chronic cheilitis.展开更多
食品风味配料的安全性监管对公共健康至关重要。美国的监管体系以其成熟的评估机制和透明的政策在全球范围内具有重要影响力。美国的监管体系始于1938年的《联邦食品、药品和化妆品法案》,1958年的食品添加剂修正案进一步完善了监管框架...食品风味配料的安全性监管对公共健康至关重要。美国的监管体系以其成熟的评估机制和透明的政策在全球范围内具有重要影响力。美国的监管体系始于1938年的《联邦食品、药品和化妆品法案》,1958年的食品添加剂修正案进一步完善了监管框架,引入了“一般公认安全”(generally recognized as safe,GRAS)物质的定义。美国食用香料与萃取物制造者协会专家小组基于严格的科学标准对风味成分进行评估,并通过GRAS清单发布结果。该体系不仅在美国国内广泛应用,还对国际组织和其他国家的监管体系产生了深远影响。相比之下,中国的食品风味配料监管体系也在不断完善,形成了以国家市场监督管理总局为主导的多部门协同监管模式,以国家标准和法规为基础,强调政府的主导作用。通过对比分析,揭示中美两国在食品风味配料监管体系上的差异,并提出了对我国监管体系优化的建议,旨在推动食品行业的安全、有序发展。展开更多
文摘This study used non-invasive evaluation methods measured six skin physiological parameters of the lower lip in 180 subjects,including moisture content,transepidermal water loss(TEWL),smoothness(SESM),scaliness of the skin(SESC),wrinkles(SEW),and red area of the lip skin,and compared the effects of 6 groups of lip balms(no-additive group,marine oligosaccharides group,ceramides group,glycyrrhizinic acid group,allantoin group,and mixed group;30 each)on the skin physiological parameters of dry,flaking,and cracked lip subjects.The results showed that the lip mositure content of the subjects in the marine oligosaccharide group,glycyrrhetinic acid group,and allantoin group increased significantly by 44.40%,42.84%and 58.08%after 7 days of lip balm(P<0.05).The TEWL in the ceramide group and the allantoin group was significantly reduced by 21.83%and 24.72%,respectively,after 7 days of lip paste use(P<0.05).The lip skin smoothness values of subjects in the glycyrrhizic acid group and the allantoin group were significantly reduced by 18.76%and 14.97%,respectively,after 28 days of lip balm application(P<0.05).The lip skin scaling indices of subjects in the marine oligosaccharide group,the ceramides group,and the allantoin group were significantly reduced by 33.77%,42.69%,and 38.07%,respectively,after 28 days of lip balm application(P<0.05).The wrinkle parameters of the lip skin of the subjects in the marine oligosaccharide,glycyrrhizinic acid and allantoin groups were significantly reduced by 23.06%,23.29%and 25.98%,respectively,after 28 days of lip balm application(P<0.05).And the area of the red zone of the lip skin of the subjects in the allantoin group was significantly reduced by 4.27%,after 28 days of lip balm application(P<0.05).Combining the effects of the four active ingredients on the secretion of hyaluronic acid(moisturizing effect)and inflammatory factor(IL-6)in HSF cells,it suggests that marine oligosaccharides and allantoin have a perfect impact on enhancing the water content of the skin on the lips of the subjects,and further improve the symptoms of flaking and wrinkles on the lips of the subjects.The ceramide and allantoin can repair the skin barrier well and have a good effect on the chapped and flaky lips of the subjects.After 28 days of using lip balm,the water content of lips in the mixed group increased,the skin barrier was repaired and became smoother,and the wrinkles,scale index,and red zone value were reduced,which could well relieve chronic lip inflammation and lay a foundation for developing lip products for the treatment of chronic cheilitis.
文摘食品风味配料的安全性监管对公共健康至关重要。美国的监管体系以其成熟的评估机制和透明的政策在全球范围内具有重要影响力。美国的监管体系始于1938年的《联邦食品、药品和化妆品法案》,1958年的食品添加剂修正案进一步完善了监管框架,引入了“一般公认安全”(generally recognized as safe,GRAS)物质的定义。美国食用香料与萃取物制造者协会专家小组基于严格的科学标准对风味成分进行评估,并通过GRAS清单发布结果。该体系不仅在美国国内广泛应用,还对国际组织和其他国家的监管体系产生了深远影响。相比之下,中国的食品风味配料监管体系也在不断完善,形成了以国家市场监督管理总局为主导的多部门协同监管模式,以国家标准和法规为基础,强调政府的主导作用。通过对比分析,揭示中美两国在食品风味配料监管体系上的差异,并提出了对我国监管体系优化的建议,旨在推动食品行业的安全、有序发展。
