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TWEAK、KIM-1及RPR与系统性红斑狼疮患儿疾病活动程度、肾损伤的相关性分析
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作者 赵申 李俊杰 《中国免疫学杂志》 北大核心 2025年第3期675-679,共5页
目的:探讨肿瘤坏死因素样凋亡微弱诱导剂(TWEAK)、肾损伤因子1(KIM-1)及红细胞分布宽度/血小板比值(RPR)与系统性红斑狼疮(SLE)患儿疾病活动度、肾损伤的关系。方法:收集2020年2月至2022年2月襄阳市中心医院42例初诊SLE患儿(SLE组),另... 目的:探讨肿瘤坏死因素样凋亡微弱诱导剂(TWEAK)、肾损伤因子1(KIM-1)及红细胞分布宽度/血小板比值(RPR)与系统性红斑狼疮(SLE)患儿疾病活动度、肾损伤的关系。方法:收集2020年2月至2022年2月襄阳市中心医院42例初诊SLE患儿(SLE组),另收集同期40例健康体检新生儿作为对照组;将SLE患儿根据系统性红斑狼疮疾病活动指数(SLEDAI)评分分为(≤9分)24例和高疾病活动度组(>9分)18例,根据是否伴有肾脏损害分为LN组31例和非LN组11例。检测所有受试对象红细胞分布宽度(RDW)和血小板计数(PLT),并计算RPR;ELISA法检测血清TWEAK、KIM-1水平。结果:SLE组血清TWEAK、KIM-1及RPR水平均显著高于对照组(P<0.05);高疾病活动度组SLE患儿血清TWEAK、KIM-1及RPR水平均显著高于低疾病活动度组(P<0.05);LN组患儿血清TWEAK、KIM-1及RPR水平均显著高于非LN组(P<0.05)。相关性分析显示,RPR与SLEDAI评分呈显著正相关(P<0.05),TWEAK、KIM-1与24 h尿蛋白呈显著正相关(P<0.05)。RPR评估SLE高疾病活动度的AUC为0.744(95%CI 0.657~0.818),显著大于TWEAK、KIM-1评估的AUC分别为0.678(95%CI:0.588~0.760)和0.598(95%CI:0.505~0.686,P<0.05);TWEAK和KIM-1预测LN的AUC分别为0.847(95%CI:0.773~0.905)和0.773(95%CI:0.690~0.842),显著大于RPR预测的AUC为0.645(95%CI:0.555~0.727,P<0.05)。结论:SLE患儿存在TWEAK、KIM-1及RPR水平变化,其中RPR对SLE疾病活动度具有较高的诊断效能,而TWEAK和KIM-1对LN预测价值较高。 展开更多
关键词 系统性红斑狼疮 肿瘤坏死因素样凋亡微弱诱导剂 肾损伤因子1 红细胞分布宽度/血小板比值 疾病活动度 狼疮性肾炎
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Experimental investigation on weak shock wave mitigation characteristics of flexible polyurethane foam and polyurea 被引量:2
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作者 Shiyu Jia Cheng Wang +2 位作者 Wenlong Xu Dong Ma Fangfang Qi 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第1期179-191,共13页
In recent years,explosion shock wave has been considered as a signature injury of the current military conflicts.Although strong shock wave is lethal to the human body,weak shock wave can cause many more lasting conse... In recent years,explosion shock wave has been considered as a signature injury of the current military conflicts.Although strong shock wave is lethal to the human body,weak shock wave can cause many more lasting consequences.To investigate the protection ability and characteristics of flexible materials and structures under weak shock wave loading,the blast wave produced by TNT explosive is loaded on the polyurethane foam with the density of 200.0 kg/m3(F-200)and 400.0 kg/m3(F-400),polyurea with the density of 1100.0 kg/m^(3)(P-1100)and structures composed of the two materials,which are intended for individual protection.Experimental results indicate that the shock wave is attenuated to weak pressure disturbance after interacting with the flexible materials which are not damaged.The shock wave protective capability of single-layer materials is dependent on their thickness,density and microscopic characteristics.The overpressure,maximum pressure rise rate and impulse of transmitted wave decrease exponentially with increase in sample thickness.For the same thickness,F-400 provides better protective capability than F-200 while P-1100 shows the best protective capability among the three materials.In this study,as the materials are not destroyed,F-200 with a thickness more than10.0 mm,F-400 with a thickness more than 4.0 mm,and P-1100 with a thickness more than 1.0 mm can attenuate the overpressure amplitude more than 90.0%.Further,multi-layer flexible composites are designed.Different layer layouts of designed structures and layer thickness of the single-layer materials can affect the protective performance.Within the research range,the structure in which polyurea is placed on the impact side shows the optimal shock wave protective performance,and the thicknesses of polyurea and polyurethane foam are 1.0 mm and 4.0 mm respectively.The overpressure attenuation rate reached maximum value of 93.3%and impulse attenuation capacity of this structure are better than those of single-layer polyurea and polyurethane foam with higher areal density. 展开更多
关键词 Free-field explosion weak shock wave mitigation POLYUREA Polyurethane foam Multi-layered composites
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Influence of confined water on the limit support pressure of tunnel face in weakly water-rich strata
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作者 LI Yun-fa WU Guo-jun +2 位作者 CHEN Wei-zhong YUAN Jing-qiang HUO Meng-zhe 《Journal of Central South University》 SCIE EI CAS CSCD 2024年第8期2844-2859,共16页
In the process of shield tunneling through soft soil layers,the presence of confined water ahead poses a significant threat to the stability of the tunnel face.Therefore,it is crucial to consider the impact of confine... In the process of shield tunneling through soft soil layers,the presence of confined water ahead poses a significant threat to the stability of the tunnel face.Therefore,it is crucial to consider the impact of confined water on the limit support pressure of the tunnel face.This study employed the finite element method(FEM)to analyze the limit support pressure of shield tunnel face instability within a pressurized water-containing layer.Subsequently,a multiple linear regression approach was applied to derive a concise solution formula for the limit support pressure,incorporating various influencing factors.The analysis yields the following conclusions:1)The influence of confined water on the instability mode of the tunnel face in soft soil layers makes the displacement response of the strata not significant when the face is unstable;2)The limit support pressure increases approximately linearly with the pressure head,shield tunnel diameter,and tunnel burial depth.And inversely proportional to the thickness of the impermeable layer,soil cohesion and internal friction angle;3)Through an engineering case study analysis,the results align well with those obtained from traditional theoretical methods,thereby validating the rationality of the equations proposed in this paper.Furthermore,the proposed equations overcome the limitation of traditional theoretical approaches considering the influence of changes in impermeable layer thickness.It can accurately depict the dynamic variation in the required limit support pressure to maintain the stability of the tunnel face during shield tunneling,thus better reflecting engineering reality. 展开更多
关键词 weakly water-rich strata confined aquifer limit support pressure finite element method multiple linear regression
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血清suPAR、BDNF、sTWEAK水平与类风湿关节炎患者疾病活动度及骨密度的相关性 被引量:4
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作者 王春雨 赵金英 +2 位作者 杜军 徐进 吴小芬 《医学研究与战创伤救治》 CAS 北大核心 2024年第5期488-492,共5页
目的研究血清可溶性尿激酶型纤溶酶原激活剂受体(suPAR)、脑源性神经营养因子(BDNF)、可溶性肿瘤坏死因子样细胞凋亡弱诱导因子(sTWEAK)水平与类风湿关节炎患者疾病活动度及骨密度的相关性。方法选取2021年1月至2023年7月解放军联勤保... 目的研究血清可溶性尿激酶型纤溶酶原激活剂受体(suPAR)、脑源性神经营养因子(BDNF)、可溶性肿瘤坏死因子样细胞凋亡弱诱导因子(sTWEAK)水平与类风湿关节炎患者疾病活动度及骨密度的相关性。方法选取2021年1月至2023年7月解放军联勤保障部队第九四○医院内分泌科收治的类风湿关节炎患者140例为类风湿关节炎组,以及2021年1月至2023年7月至本院体检中心体检健康者70例为对照组。评估患者组疾病活动度,测定骨密度。检测对照组和类风湿关节炎组的血清suPAR、BDNF、sTWEAK水平。根据疾病活动度水平将类风湿关节炎组患者再分为低度亚组(2.6~3.2)、中度亚组(3.2~5.1)、高度亚组(>5.1)。比较类风湿关节炎组与对照组、3个亚组的suPAR、BDNF、sTWEAK、骨密度;分析suPAR、BDNF、sTWEAK与疾病活动度、骨密度的相关性;分析suPAR、BDNF、sTWEAK联合检测在预测疾病加重风险中的价值。结果类风湿关节炎组血清suPAR、BDNF、sTWEAK高于对照组(P<0.05)。高度亚组血清suPAR、BDNF、sTWEAK明显大于中度亚组和低度亚组(P<0.05),中度亚组血清suPAR、BDNF、sTWEAK明显大于低度亚组(P<0.05)。类风湿关节炎组前臂远端、腰椎L1-4、股骨颈、髋关节的骨密度小于对照组(P<0.05)。高度组前臂远端、腰椎L1-4、股骨颈、髋关节骨密度明显小于中度亚组和低度亚组,中度亚组前臂远端、腰椎L1-4、股骨颈、髋关节骨密度明显小于低度亚组(P<0.05)。血清suPAR、BDNF、sTWEAK与疾病活动度呈正相关,与前臂远端、腰椎L1-4、股骨颈、髋关节的骨密度呈负相关(P<0.05)。联合suPAR、BDNF、sTWEAK三项指标预测疾病活动度升高风险的AUC大于单独预测的AUC(P=0.000)。结论类风湿关节炎患者suPAR、BDNF、sTWEAK与疾病活动度呈正相关,与骨密度呈负相关,联合检测suPAR、BDNF、sTWEAK可为预测患者疾病未来变化趋势提供有效指导。 展开更多
关键词 类风湿关节炎 可溶性尿激酶型纤溶酶原激活剂受体 脑源性神经营养因子 可溶性肿瘤坏死因子样细胞凋亡弱诱导因子 疾病活动度 骨密度 相关性
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纤维增强复合材料拉伸强度的weak-link比例预测 被引量:3
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作者 王放 曾祥国 +1 位作者 魏玉卿 张俊乾 《四川大学学报(工程科学版)》 EI CAS CSCD 北大核心 2009年第4期136-140,150,共6页
为了讨论weak-link比例对强度预测的适用范围,基于纤维增强复合材料的渐进破坏机理,考虑纤维强度的统计特性,采用Monte-Carlo方法对材料在热/机械载荷作用下的拉伸强度分布进行了数值模拟分析。研究结果表明,在形状参数β=10的条件下,... 为了讨论weak-link比例对强度预测的适用范围,基于纤维增强复合材料的渐进破坏机理,考虑纤维强度的统计特性,采用Monte-Carlo方法对材料在热/机械载荷作用下的拉伸强度分布进行了数值模拟分析。研究结果表明,在形状参数β=10的条件下,如果希望通过weak-link缩放比例对大尺寸材料的强度分布进行预测,则复合材料的临界尺寸应达到25根纤维的规模。小尺寸材料拉伸强度的分散性趋于稳定,即达到临界尺寸,是采用weak-link比例预测大尺寸材料强度分布规律的先决条件。研究方法为进一步发展基于损伤机理分析的复合材料在循环载荷作用下的疲劳寿命预测理论奠定了基础。 展开更多
关键词 纤维增强复合材料 拉伸强度 weak-link比例
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TWEAK及其受体Fn14在大鼠骨关节炎(OA)关节软骨和滑膜中的表达 被引量:3
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作者 蔡国平 俞永林 +2 位作者 熊敏 张新潮 刘德昌 《复旦学报(医学版)》 CAS CSCD 北大核心 2013年第3期265-270,共6页
目的检测肿瘤坏死因子样弱凋亡诱导因子(tumor necrosis factor-like weak inducer of apoptosis,TWEAK)及其受体成纤维细胞生长因子诱导因子14(fibroblast growth factor inducible 14,Fn14)mRNA及蛋白在大鼠骨关节炎(osteoarthritis,... 目的检测肿瘤坏死因子样弱凋亡诱导因子(tumor necrosis factor-like weak inducer of apoptosis,TWEAK)及其受体成纤维细胞生长因子诱导因子14(fibroblast growth factor inducible 14,Fn14)mRNA及蛋白在大鼠骨关节炎(osteoarthritis,OA)关节软骨和滑膜中的表达情况,初步了解TWEAK及其受体Fn14在OA发病中的作用。方法 42只大鼠中随机选取18只行膝关节前交叉韧带切断(anterior cruciate ligamenttransection,ACLT)制作OA模型作为实验组,另外18只接受手术但不切断前交叉韧带作为假手术组,剩余6只作为正常对照组。饲养至1、2、4周时,实验组及假手术组随机各取6只处死,6只正常对照组在第4周处死,采集所有动物关节软骨及滑膜组织,用实时定量PCR及Western blot分别检测TWEAK和Fn14在mRNA及蛋白水平的表达情况。结果术后第2和第4周实验组动物关节滑膜中TWEAK及Fn14的mRNA及蛋白表达水平显著上调,与假手术组及正常对照组比较,差异均有统计学意义(P<0.05);术后第2周实验组动物关节软骨中TWEAK及Fn14的mRNA及蛋白表水平与假手术组及正常对照组比较,差异均有统计学意义(P<0.05)。结论 TWEAK及其受体Fn14的mRNA及蛋白表达水平在大鼠OA关节软骨及滑膜组织中的表达显著增高,它们可能是参与OA的重要细胞诱导因子。 展开更多
关键词 骨关节炎(OA) 肿瘤坏死因子样弱凋亡诱导因子(Tweak) 成纤维细胞生长因子诱导因子14(Fn14)
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参苓白术散对肿瘤恶病质患者TNF-α、TWEAK、Fn14表达的影响 被引量:16
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作者 胡成琳 胡陵静 +1 位作者 叶海英 张国铎 《重庆医科大学学报》 CAS CSCD 北大核心 2019年第7期950-953,共4页
目的:观察参苓白术散对肿瘤恶病质患者血清肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、肿瘤坏死因子弱凋亡诱导剂(tumor necrosis factor-like weak inducer of apoptosis,TWEAK)、成纤维细胞生长诱导因子-14(fibroblast growt... 目的:观察参苓白术散对肿瘤恶病质患者血清肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、肿瘤坏死因子弱凋亡诱导剂(tumor necrosis factor-like weak inducer of apoptosis,TWEAK)、成纤维细胞生长诱导因子-14(fibroblast growth factor-inducible 14,Fn14)表达的影响。方法:将64例诊断符合肿瘤恶病质,辨证属于脾气虚证患者,随机分为2组。对照组32例,予以复方氨基酸等营养支持治疗;治疗组32例,在营养支持治疗基础上加用参苓白术散汤剂,水煎服,每日1剂,分3次温服,共用4周。观察治疗前后中医临床证候、生存质量评定(Kanrofsky score,KPS)、TNF-α、TWEAK及其受体早期反应蛋白Fn14。结果:治疗组和对照组脾气虚证患者治疗后比较,中医证候总有效率分别为40.62%和15.62%,治疗组明显优于对照组(P<0.05)。在KPS评分改善率方面,治疗组优于对照组(P<0.05)。2组治疗后TNF-α、TWEAK、Fn14均降低,治疗组治疗前后差异有统计学意义(P<0.05),2组间比较,治疗后治疗组TNF-α、TWEAK、Fn14降低更为显著,差异均有统计学意义(P<0.05)。结论:参苓白术散与营养支持相联合,可改善肿瘤恶病质患者中医证候,提高患者体力状况,降低患者体内TNF-α、TWEAK、Fn14表达,提示参苓白术散可能通过该途径起到控制肿瘤恶病质发生的作用。 展开更多
关键词 参苓白术散 肿瘤恶病质 血清肿瘤坏死因子-Α 肿瘤坏死因子弱凋亡诱导剂 成纤维细胞生长诱导因子-14
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Triaxial creep tests of weak sandstone from fracture zone of high dam foundation 被引量:12
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作者 张玉 徐卫亚 +1 位作者 顾锦健 王伟 《Journal of Central South University》 SCIE EI CAS 2013年第9期2528-2536,共9页
The lithology of fracture zone which was developed at the dam foundation of a hydropower station is weak sandstone with poor integrity and pore cementation contact.Its creep properties have a significant impact on the... The lithology of fracture zone which was developed at the dam foundation of a hydropower station is weak sandstone with poor integrity and pore cementation contact.Its creep properties have a significant impact on the deformation and stability of the dam.Based on the characteristics of loose organizational structure,high moisture content and poor mechanical properties,the triaxial compression tests and creep tests were carried out,respectively.The results show significant non-linear,low strength and no obvious strength peaks.Both axial and lateral strains are achieved more than 3%when the tests are failed.The weak sandstone has a significant creep property,but only transient and steady state appear under low stress.Increased stress causes creep intensified and lateral strain gradually exceeds axial strain.In the failure stage,it has characteristics of large axial plastic deformation,obvious volumetric ductility dilation and large steady creep rate.The accelerated creep appears shortly after transient loading under confining of pressures 1.0 MPa and 1.5 MPa.Therefore,an improved Burgers creep model considering the non-linear characteristics of weak sandstone is built based on hyperbolic equation and the creep parameters are identified.This model can well describe the creep properties of weak sandstone. 展开更多
关键词 hydropower station weak sandstone creep properties triaxial compression tests triaxial creep tests improved Burgers creep model
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Weak thruster fault detection for AUV based on stochastic resonance and wavelet reconstruction 被引量:5
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作者 刘维新 王玉甲 +1 位作者 刘星 张铭钧 《Journal of Central South University》 SCIE EI CAS CSCD 2016年第11期2883-2895,共13页
When the bi-stable stochastic resonance method was applied to enhance weak thruster fault for autonomous underwater vehicle(AUV), the enhancement performance could not satisfy the detection requirement of weak thruste... When the bi-stable stochastic resonance method was applied to enhance weak thruster fault for autonomous underwater vehicle(AUV), the enhancement performance could not satisfy the detection requirement of weak thruster fault. As for this problem, a fault feature enhancement method based on mono-stable stochastic resonance was proposed. In the method, in order to improve the enhancement performance of weak thruster fault feature, the conventional bi-stable potential function was changed to mono-stable potential function which was more suitable for aperiodic signals. Furthermore, when particle swarm optimization was adopted to adjust the parameters of mono-stable stochastic resonance system, the global convergent time would be long. An improved particle swarm optimization method was developed by changing the linear inertial weighted function as nonlinear function with cosine function, so as to reduce the global convergent time. In addition, when the conventional wavelet reconstruction method was adopted to detect the weak thruster fault, undetected fault or false alarm may occur. In order to successfully detect the weak thruster fault, a weak thruster detection method was proposed based on the integration of stochastic resonance and wavelet reconstruction. In the method, the optimal reconstruction scale was determined by comparing wavelet entropies corresponding to each decomposition scale. Finally, pool-experiments were performed on AUV with thruster fault. The effectiveness of the proposed mono-stable stochastic resonance method in enhancing fault feature and reducing the global convergent time was demonstrated in comparison with particle swarm optimization based bi-stochastic resonance method. Furthermore, the effectiveness of the proposed fault detection method was illustrated in comparison with the conventional wavelet reconstruction. 展开更多
关键词 autonomous underwater vehicle(AUV) THRUSTER weak fault particle swarm optimization(PSO) mono-stable stochastic resonance wavelet reconstruction
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sTWEAK,hsCRP在急性冠脉综合征的表达及临床意义 被引量:6
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作者 易光兆 罗素新 +2 位作者 文俊杰 何东 曾倩倩 《重庆医科大学学报》 CAS CSCD 北大核心 2014年第1期64-68,共5页
目的:通过检测急性冠脉综合征(acute coronary syndrome,ACS)患者可溶性肿瘤坏死因子样凋亡弱诱导因子(soluble tumor necrosis factor-like weak inducer of apoptosis,sTWEAK)血浆浓度和高敏C反应蛋白(high sensitivity C-reaction pr... 目的:通过检测急性冠脉综合征(acute coronary syndrome,ACS)患者可溶性肿瘤坏死因子样凋亡弱诱导因子(soluble tumor necrosis factor-like weak inducer of apoptosis,sTWEAK)血浆浓度和高敏C反应蛋白(high sensitivity C-reaction protein,hsCRP)血清浓度,探讨sTWEAK、hsCRP对ACS诊断的临床价值。方法:收集2012年9月1日至2013年3月31在重庆医科大学附属第一医院心血管内科住院的ACS患者62例,其中男性47例(75.81%),年龄(66.06±9.89)岁,同时收集同期住院患者中冠脉造影或冠脉CT证实的稳定性心绞痛(stable angina pectoris,SAP)患者19例以及冠脉造影排除冠心病的患者(对照组)29例。ACS组再分为ST段抬高性心肌梗死(ST-segment elevation myocardial infarction,STEMI),非ST段抬高性心肌梗死(non STsegment elevation myocardial infarction,NSTEMI)和不稳定性心绞痛(unstable angina pectoris,UAP)3个亚组,分别有11例,14例和37例。采用酶联免疫吸附法(enzyme linked immunosorbent assay,ELISA)检测患者sTWEAK血浆浓度,免疫比浊法检测hsCRP血清浓度。统计分析3组患者和ACS 3个亚组间sTWEAK血浆浓度、hsCRP血清浓度是否存在差异,ACS组sTWEAK与hsCRP、cTn的相关性,以及三支病变与非三支病变的差异。结果:①ACS组、SAP组和对照组sTWEAK血浆浓度分别为139.95(121.30,155.51)、93.21(84.37,114.08)ng/L和124.24(118.32,135.49)ng/L,显示ACS组较SAP组和对照组高(P=0.000,P=0.007),SAP组较对照组低(P=0.000)。②3组hsCRP血清浓度分别为2.29(0.84,9.77)、1.40(0.47,1.96)mg/L和0.87(0.46,1.75)mg/L,显示ACS组较ASP组和对照组高(P=0.015,P=0.001),SAP组与对照组无统计学差异(P=0.62)。③ACS 3个亚组间sTWEAK血浆浓度无统计学差异(P=0.41),STEMI组和NSTEMI组hsCRP血清浓度高于UAP组(P=0.001,P=0.027),STEMI组与NSTEMI组hsCRP血清浓度无统计学差异(P=0.202)。④ACS组sTWEAK血浆浓度和hsCRP血清浓度无直线相关(P=0.462),hsCRP与cTn呈正相关(r=0.578,P=0.000),三支病变组与非三支病变组的sTWEAK和hsCRP无统计学差异(P=0.533,P=0.569)。结论:sTWEAK血浆浓度、hsCRP血清浓度在ACS患者中升高,对ACS的诊断具有一定价值。 展开更多
关键词 可溶性肿瘤坏死因子样凋亡弱诱导因子 高敏C反应蛋白 冠心病 急性冠脉综合征 ST段抬高性心肌梗死
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Tunnel failure in hard rock with multiple weak planes due to excavation unloading of in-situ stress 被引量:12
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作者 CHEN Shao-jie FENG Fan +4 位作者 WANG Ya-jun LI Di-yuan HUANG Wan-peng ZHAO Xing-dong JIANG Ning 《Journal of Central South University》 SCIE EI CAS CSCD 2020年第10期2864-2882,共19页
Natural geological structures in rock(e.g.,joints,weakness planes,defects)play a vital role in the stability of tunnels and underground operations during construction.We investigated the failure characteristics of a d... Natural geological structures in rock(e.g.,joints,weakness planes,defects)play a vital role in the stability of tunnels and underground operations during construction.We investigated the failure characteristics of a deep circular tunnel in a rock mass with multiple weakness planes using a 2D combined finite element method/discrete element method(FEM/DEM).Conventional triaxial compression tests were performed on typical hard rock(marble)specimens under a range of confinement stress conditions to validate the rationale and accuracy of the proposed numerical approach.Parametric analysis was subsequently conducted to investigate the influence of inclination angle,and length on the crack propagation behavior,failure mode,energy evolution,and displacement distribution of the surrounding rock.The results show that the inclination angle strongly affects tunnel stability,and the failure intensity and damage range increase with increasing inclination angle and then decrease.The dynamic disasters are more likely with increasing weak plane length.Shearing and sliding along multiple weak planes are also consistently accompanied by kinetic energy fluctuations and surges after unloading,which implies a potentially violent dynamic response around a deeply-buried tunnel.Interactions between slabbing and shearing near the excavation boundaries are also discussed.The results presented here provide important insight into deep tunnel failure in hard rock influenced by both unloading disturbance and tectonic activation. 展开更多
关键词 rock tunnel weak planes excavation unloading crack propagation energy evolution finite element method/discrete element method(FEM/DEM)
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Response models of weakly consolidated soft rock roadway under different interior pressures considering dilatancy effect 被引量:6
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作者 赵增辉 王渭明 王磊 《Journal of Central South University》 SCIE EI CAS 2013年第12期3736-3744,共9页
Surrounding rocks of weakly consolidated soft rock roadway show obvious strain softening and dilatancy effects after excavation. A damage coefficient concerning modulus attenuation was defined. Response models of stre... Surrounding rocks of weakly consolidated soft rock roadway show obvious strain softening and dilatancy effects after excavation. A damage coefficient concerning modulus attenuation was defined. Response models of stress and displacement of surrounding rock of soft rock roadway and analytical expressions to calculate plastic zones under different interior pressures and non-uniform original rock stresses were derived based on damage theories and a triple linear elastic-plastic strain softening model. Influence laws of dilatancy gradient on damage development, distributions of stresses and displacement in plastic region were analyzed. Interior pressure conditions to develop plastic region under different origin rock stresses were established and their influences on plastic region distribution were also discussed. The results show that the order of maximum principle stress is exchanged between ~0 and trr with the increase of interior pressure P0, which causes distributions of plastic zone and stress shift. Dilatancy effect which has great influences on the damage propagation and displacements in plastic region has little effect on the size of plastic region and stress responses. The conclusions provide a theoretical basis for a reasonable evaluation of stability and effective supporting of weakly consolidated soft rock roadway. 展开更多
关键词 weakly consolidated soft rock roadway dilatancy effect modulus damage coefficient cave interior pressure responsemodel
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Detection of weak target for MIMO radar based on Hough transform 被引量:2
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作者 Zeng Jiankui He Zishu 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2009年第1期76-80,共5页
An effective method of multiple input multiple output (MIMO) radar weak target detection is proposed based on the Hough transform. The detection time duration is divided into multiple coherent processing intervals ... An effective method of multiple input multiple output (MIMO) radar weak target detection is proposed based on the Hough transform. The detection time duration is divided into multiple coherent processing intervals (CPIs). Within each CPI, conventional methods such as fast Fourier transform (FFT) is exploit to coherent inte- grating in same range cell. Furthermore, noncoherent integration through several range cells can be implemented by Hough transform among all CPIs. Thus, higher integration gain can be obtained. Simulation results are also given to demonstrate that the detection performance of weak moving target can be dramatically improved. 展开更多
关键词 MIMO radar weak target detection Hough transform noncoherent integration.
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Prediction of efficient outputs based on GM(1,N) model and weak DEA efficiency 被引量:2
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作者 Jiefang Wang Sifeng Liu 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2011年第6期933-939,共7页
This paper expresses the efficient outputs of decisionmaking unit(DMU) as the sum of "average outputs" forecasted by a GM(1,N) model and "increased outputs" which reflect the difficulty to realize efficient ou... This paper expresses the efficient outputs of decisionmaking unit(DMU) as the sum of "average outputs" forecasted by a GM(1,N) model and "increased outputs" which reflect the difficulty to realize efficient outputs.The increased outputs are solved by linear programming using data envelopment analysis efficiency theories,wherein a new sample is introduced whose inputs are equal to the budget in the issue No.n + 1 and outputs are forecasted by the GM(1,N) model.The shortcoming in the existing methods that the forecasted efficient outputs may be less than the possible actual outputs according to developing trends of input-output rate in the periods of pre-n is overcome.The new prediction method provides decision-makers with more decisionmaking information,and the initial conditions are easy to be given. 展开更多
关键词 efficient outputs GM(1 N) model data envelopment analysis(DEA) weak DEA efficiency prediction.
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Vector tracking loops in GNSS receivers for dynamic weak signals 被引量:2
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作者 Jing Liu Xiaowei Cui +1 位作者 Mingquan Lu Zhenming Feng 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2013年第3期349-364,共16页
Vehicle positioning with the global navigation satellite system (GNSS) in urban environments faces two problems which are attenuation and dynamic. For traditional GNSS receivers hardly able to track dynamic weak sig... Vehicle positioning with the global navigation satellite system (GNSS) in urban environments faces two problems which are attenuation and dynamic. For traditional GNSS receivers hardly able to track dynamic weak signals, the coupling between all visible satellite signals is ignored in the absence of navigation state feedback, and thermal noise error and dynamic stress threshold are contradictory due to non-coherent discriminators. The vector delay/frequency locked loop (VDFLL) with navigation state feedback and the joint vector tracking loop (JVTL) with coherent discriminator which is a synchronization parameter tracking loop based on maximum likelihood estimation (MLE) are proposed to improve the tracking sensitivity of GNSS receiver in dynamic weak signal environments. A joint vector position tracking loop (JVPTL) directly tracking user position and velocity is proposed to further improve tracking sensitivity. The coherent navigation parameter discriminator of JVPTL, being able to ease the contradiction between thermal noise error and dynamic stress threshold, is based on MLE according to the navigation parameter based linear model of received baseband signals. Simulation results show that JVPTL, which combines the advantages of both VDFLL and JVTL, performs better than both VDFLL and JVTL in dynamic weak signal environments. 展开更多
关键词 dynamic weak signal maximum likelihood estimation (MLE) linear model navigation state feedback coherent discriminator
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HBV转染对TWEAK诱导凋亡的影响及IFN-γ对凋亡的调节 被引量:1
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作者 冷向锋 张秋 +1 位作者 孙汶生 陈振雨 《中国病理生理杂志》 CAS CSCD 北大核心 2010年第2期341-344,共4页
目的:探讨新型凋亡分子TNF-like weak inducer of apoptosis(TWEAK)对乙型肝炎病毒(HBV)转染的人肝癌细胞系的凋亡诱导作用及γ-干扰素(IFN-γ)对该凋亡过程的影响。方法:以稳定转染了pCD-NA3/1.1HBV的肝癌细胞系BEL-7402-pCDNA3/1.1HB... 目的:探讨新型凋亡分子TNF-like weak inducer of apoptosis(TWEAK)对乙型肝炎病毒(HBV)转染的人肝癌细胞系的凋亡诱导作用及γ-干扰素(IFN-γ)对该凋亡过程的影响。方法:以稳定转染了pCD-NA3/1.1HBV的肝癌细胞系BEL-7402-pCDNA3/1.1HBV为模型,并以稳定转染空载体的肝癌细胞BEL-7402/pcDNA3作为对照,经CCK-8法检测HBV转染前后TWEAK对细胞生长的抑制效应,terminal transferase dUTP nick end labeling(TUNEL)、半胱氨酸天冬氨酸蛋白酶-3(caspase-3)活性检测试剂盒检测HBV转染前后TWEAK诱导肝癌细胞的凋亡情况及IFN-γ对TWEAK诱导细胞凋亡的调节作用。结果:HBV转染促进TWEAK诱导的细胞凋亡,IFN-γ可以增强HBV转染细胞对TWEAK诱导凋亡的敏感性。结论:机体感染HBV后,TWEAK可能参与HBV感染肝细胞的清除过程;IFN-γ在调节TWEAK诱导的病毒感染细胞凋亡中发挥重要作用。 展开更多
关键词 肝炎病毒 乙型 细胞凋亡 干扰素-Γ 肿瘤坏死因子样凋亡微弱诱导剂
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M-FCN based sea-surface weak target detection 被引量:3
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作者 PAN Meiyan SUN Jun +2 位作者 YANG Yuhao LI Dasheng YU Junpeng 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2021年第5期1111-1118,共8页
This paper focuses on the sea-surface weak target detection based on memory-fully convolutional network(M-FCN)in strong sea clutter.Firstly,the constant false alarm rate(CFAR)detection method utilizes a low threshold ... This paper focuses on the sea-surface weak target detection based on memory-fully convolutional network(M-FCN)in strong sea clutter.Firstly,the constant false alarm rate(CFAR)detection method utilizes a low threshold with high probability of false alarm to detect sea-surface weak targets after non-coherent integration.Reducing the detection threshold can generate a large number of false alarms while increasing the detection rate,and how to suppress a large number of false alarms is the key to improve the performance of weak target detection.Then,the detection result of the low threshold is operated to construct the target matrix suitable for the size of fully convolutional networks and the convolution operator form.Finally,the M-FCN architecture is designed to learn the different accumulation characteristics of the target and the sea clutter between different frames.For improving the detection performance,the historical multi-frame information is memorized by the network,and the end-to-end structure is established to detect sea-surface weak target automatically.Experimental results on measured data demonstrate that the M-FCN method outperforms the traditional track before detection(TBD)method and reduces false alarm tracks by 35.1%,which greatly improves the track quality. 展开更多
关键词 sea-surface weak target detection memory-fully convolutional network(M-FCN) multi-frame information END-TO-END
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Adsorption of Pb^(2+) on macroporous weak acid adsorbent resin from aqueous solutions: Batch and column studies 被引量:2
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作者 熊春华 冯宇杰 姚彩萍 《Journal of Central South University》 SCIE EI CAS 2009年第4期569-574,共6页
The adsorption properties of a novel macroporous weak acid resin (D152) for Pb^2+ were investigated with chemical methods. The optimal adsorption condition of D152 resin for Pb^2+ is at pH 6.00 in HAc-NaAc medium.... The adsorption properties of a novel macroporous weak acid resin (D152) for Pb^2+ were investigated with chemical methods. The optimal adsorption condition of D152 resin for Pb^2+ is at pH 6.00 in HAc-NaAc medium. The statically saturated adsorption capacity is 527 mg/g at 298 K. Pb^2+ adsorbed on D152 resin can be eluted with 0.05 mol/L HCI quantitatively. The adsorption rate constants determined under various temperatures are k288 n=2.22×10-5 s^-1, k298 K=2.51 × 10^-5 s^-1, and k308 K= 2.95 × 10^-5 s^-1, respectively. The apparent activation energy, Ea is 10.5 kJ/mol, and the adsorption parameters of thermodynamics are ΔH^Θ=13.3 kJ/mol, ΔS^Θ=119 J/(mol·K), and ΔG^Θ298 K =-22.2 kJ/mol, respectively. The adsorption behavior of D152 resin for Pb^2+ follows Langmuir model. 展开更多
关键词 Pb^2+ macroporous weak acid resin ADSORPTION thermodynamics
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Numerical analysis and field monitoring tests on shallow tunnels under weak surrounding rock 被引量:2
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作者 刘建华 刘晓明 +1 位作者 张永杰 肖庭 《Journal of Central South University》 SCIE EI CAS CSCD 2015年第10期4056-4063,共8页
The Jianpudong No. 4 tunnel is a shallow tunnel, which belongs to Shaoshan County scenic highway in Hunan province, China and whose surrounding rock is weak. According to its characteristics, the field monitoring test... The Jianpudong No. 4 tunnel is a shallow tunnel, which belongs to Shaoshan County scenic highway in Hunan province, China and whose surrounding rock is weak. According to its characteristics, the field monitoring tests and numerical analysis were done. The mechanical characteristics of shallow tunnels under weak surrounding rock and the stress-strain rule of surrounding rock and support were analyzed. The numerical analysis results show that the settlement caused by upper bench excavating accounts for 44% of the total settlement, and the settlement caused by tunnel upper bench supporting accounts for 56% of the total settlement. The maximum axial force of shotcrete lining is 177.2 k N, which locates in hance under the secondary lining. The maximum moment of shotcrete lining is 5.08 k N·m, which locates in the arch foot. The stress curve of steel arch has three obvious stages during the tunnel construction. The maximum axial force of steel arch is 297.4 k N, which locates in tunnel vault. The axial forces of steel arch are respectively 23.5 k N and-21.8 k N, which is influenced by eccentric compression of shallow tunnel and locates in hance. The results show that there is larger earth pressure in tunnel vault which is most unfavorable position of steel arch. Therefore, the advance support should be strengthened in tunnel vault during construction process. 展开更多
关键词 tunnel engineering shallow tunnel weak surrounding rock numerical analysis field monitoring tests
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Re-scaling and adaptive stochastic resonance as a tool for weak GNSS signal acquisition 被引量:2
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作者 Rongling Lang Xinyue Li +1 位作者 Fei Gao Liang Yang 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2016年第2期290-296,共7页
Weak global navigation satellite system(GNSS) signal acquisition has been a limitation for high sensitivity GPS receivers. This paper modifies the traditional acquisition algorithms and proposes a new weak GNSS sign... Weak global navigation satellite system(GNSS) signal acquisition has been a limitation for high sensitivity GPS receivers. This paper modifies the traditional acquisition algorithms and proposes a new weak GNSS signal acquisition method using re-scaling and adaptive stochastic resonance(SR). The adoption of classical SR is limited to low-frequency and periodic signals. Given that GNSS signal frequency is high and that the periodic feature of the GNSS signal is affected by the Doppler frequency shift, classical SR methods cannot be directly used to acquire GNSS signals. Therefore, the re-scaling technique is used in our study to expand its usage to high-frequency signals and adaptive control technique is used to gradually determine the Doppler shift effect in GNSS signal buried in strong noises. The effectiveness of our proposed method was verified by the simulations on GPS L1 signals. The simulation results indicate that the new algorithm based on SR can reach-181 d BW sensitivity with a very short data length of 1 ms. 展开更多
关键词 weak signal detection global navigation satellite system(GNSS) signal acquisition stochastic resonance
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