A series of water soluble N maleoyl chitosan was synthesized in an acid homogeneous solution. Their chemical structure were demonstrated by FTIR and UV spectra. The effects of the mole ratio of anhydride to amino grou...A series of water soluble N maleoyl chitosan was synthesized in an acid homogeneous solution. Their chemical structure were demonstrated by FTIR and UV spectra. The effects of the mole ratio of anhydride to amino group of chitosan in feed solution on the solubility, intrinsic viscosity() and the yield of product were studied. The results showed that the solubility of N maleoyl chitosan was greatly improved in water. The highest yield was obtained at 0 5 mole ratio of maleic anhydride to chitosan.展开更多
给小鼠喂食壳聚糖(chitosan,CS)、羧甲基壳聚糖(carboxymethyl chitosan,CMCS)、壳聚糖季铵盐(quaternary ammonium salt of chitosan,HACC)和羟丙基壳聚糖(hydroxypropyl chitosan,HPCS)30 d后,测定其免疫器官指数、碳粒廓清速率、迟...给小鼠喂食壳聚糖(chitosan,CS)、羧甲基壳聚糖(carboxymethyl chitosan,CMCS)、壳聚糖季铵盐(quaternary ammonium salt of chitosan,HACC)和羟丙基壳聚糖(hydroxypropyl chitosan,HPCS)30 d后,测定其免疫器官指数、碳粒廓清速率、迟发型变态反应、血清溶血素含量(半数溶血值HC_(50))。结果表明:摄食CS及其水溶性衍生物的小鼠以上指标均高于对照组;除胸腺指数和双耳质量差值外,HACC组小鼠其他各项免疫指标与对照组相比均呈显著或极显著差异(P<0.05或P<0.01);同样,除胸腺指数外,HPCS组小鼠其他各项免疫指标均显著或极显著高于对照组(P<0.05或P<0.01);CMCS组小鼠的吞噬指数(K)和半数溶血值(HC_(50))与对照组相比均呈显著差异(P<0.05);壳聚糖及其3种水溶性衍生物都能够增强小鼠免疫功能,增强效果排序为HPCS>HACC>CMCS>CS,这可能与引入的化学基团不同有关。展开更多
文摘A series of water soluble N maleoyl chitosan was synthesized in an acid homogeneous solution. Their chemical structure were demonstrated by FTIR and UV spectra. The effects of the mole ratio of anhydride to amino group of chitosan in feed solution on the solubility, intrinsic viscosity() and the yield of product were studied. The results showed that the solubility of N maleoyl chitosan was greatly improved in water. The highest yield was obtained at 0 5 mole ratio of maleic anhydride to chitosan.
文摘给小鼠喂食壳聚糖(chitosan,CS)、羧甲基壳聚糖(carboxymethyl chitosan,CMCS)、壳聚糖季铵盐(quaternary ammonium salt of chitosan,HACC)和羟丙基壳聚糖(hydroxypropyl chitosan,HPCS)30 d后,测定其免疫器官指数、碳粒廓清速率、迟发型变态反应、血清溶血素含量(半数溶血值HC_(50))。结果表明:摄食CS及其水溶性衍生物的小鼠以上指标均高于对照组;除胸腺指数和双耳质量差值外,HACC组小鼠其他各项免疫指标与对照组相比均呈显著或极显著差异(P<0.05或P<0.01);同样,除胸腺指数外,HPCS组小鼠其他各项免疫指标均显著或极显著高于对照组(P<0.05或P<0.01);CMCS组小鼠的吞噬指数(K)和半数溶血值(HC_(50))与对照组相比均呈显著差异(P<0.05);壳聚糖及其3种水溶性衍生物都能够增强小鼠免疫功能,增强效果排序为HPCS>HACC>CMCS>CS,这可能与引入的化学基团不同有关。
