Objective:To confirm that double-axis rotation activates vestibular nuclear complex(VNC)via stimulating vestibular endorgans.Methods:Sixteen male Sprague-Dawley rats were randomly divided equally into four groups:cont...Objective:To confirm that double-axis rotation activates vestibular nuclear complex(VNC)via stimulating vestibular endorgans.Methods:Sixteen male Sprague-Dawley rats were randomly divided equally into four groups:control,rotation,vestibular-lesioned and vestibular-lesioned plus roatation.Lesion of vestibular endorgans were accomplished through tanstympanic injection of 100 mg of sodium arsanilate.All animals were singly restrained in custommade Perspex containers and placed in darkness.Rats in rotation and vestibular-lesioned plus rotation groups were subjected to double-axis rotation for 2 h,while others as control were positioned close to the stimulator.Following stimulation,all rats were anesthetically killed and the brain tissues removed to examine Fos expression level using Western Blot.Results:Compared with normal control,rats in rotation group exhibited a tendency to increase in Fos expression in the VNC,although without statistical significance(P>0.05).The Fos expression levels in vestibular-lesioned and vestibular-lesioned plus rotation groups approximated.When normalized to the Fos expression in normal control group,the values representing Fos level in rotation,vestibular-lesioned and vestibular-leioned plus rotation groups were 1.129±0.0631,0.959±0.0487 and 1.023±0.237,respectively.Conclusion:Double-axis rotation can activate VNC neurons,and sodium arsanilate can functionally disrupt vestibular endorgans.展开更多
目的探讨SRM-Ⅳ型前庭功能诊疗系统对良性阵发性位置性眩晕(benign paroxysmal position vertigo,BPPV)的治疗效果。方法回顾性分析2015年1月至2016年3月于本院眩晕门诊就诊并接受手法复位的280例BPPV患者(手法复位组)以及2016年4月至2...目的探讨SRM-Ⅳ型前庭功能诊疗系统对良性阵发性位置性眩晕(benign paroxysmal position vertigo,BPPV)的治疗效果。方法回顾性分析2015年1月至2016年3月于本院眩晕门诊就诊并接受手法复位的280例BPPV患者(手法复位组)以及2016年4月至2016年8月于本院就诊并接受SRM-Ⅳ复位的311例BPPV患者(SRM-Ⅳ复位组)的临床资料,采用卡方检验比较两组患者不同病变部位复位的疗效、1个月内残余头晕症状发生率及6个月内的复发率。结果 SRM-Ⅳ复位组患者治疗有效率显著高于手法复位组(96.5%︰91.1%,P<0.05);其中后半规管BPPV患者手法复位和SRM-Ⅳ复位有效率分别为94.6%和99.2%,差异具有显著性(P=0.028);水平半规管BPPV患者手法复位和SRM-Ⅳ复位有效率分别为90.3%和98.8%,差异具有显著性(P=0.019)。水平半规管BPPV手法复位组患者的残余头晕症状发生率显著高于SRM-Ⅳ复位组(38.9%︰18.5%,P=0.005);后壶腹嵴和水平半规管的手法复位6个月内BPPV复发率均高于SRM-Ⅳ复位(23.8%︰3.7%,23.6%︰7.4%;P分别为0.007、0.005)。结论 SRM-Ⅳ型前庭功能诊疗系统的应用提高了BPPV的临床疗效,尤其在水平半规管BPPV的治疗中具有更高的有效率,并且降低了残余头晕症状的发生率及治疗后6个月的复发率。展开更多
文摘Objective:To confirm that double-axis rotation activates vestibular nuclear complex(VNC)via stimulating vestibular endorgans.Methods:Sixteen male Sprague-Dawley rats were randomly divided equally into four groups:control,rotation,vestibular-lesioned and vestibular-lesioned plus roatation.Lesion of vestibular endorgans were accomplished through tanstympanic injection of 100 mg of sodium arsanilate.All animals were singly restrained in custommade Perspex containers and placed in darkness.Rats in rotation and vestibular-lesioned plus rotation groups were subjected to double-axis rotation for 2 h,while others as control were positioned close to the stimulator.Following stimulation,all rats were anesthetically killed and the brain tissues removed to examine Fos expression level using Western Blot.Results:Compared with normal control,rats in rotation group exhibited a tendency to increase in Fos expression in the VNC,although without statistical significance(P>0.05).The Fos expression levels in vestibular-lesioned and vestibular-lesioned plus rotation groups approximated.When normalized to the Fos expression in normal control group,the values representing Fos level in rotation,vestibular-lesioned and vestibular-leioned plus rotation groups were 1.129±0.0631,0.959±0.0487 and 1.023±0.237,respectively.Conclusion:Double-axis rotation can activate VNC neurons,and sodium arsanilate can functionally disrupt vestibular endorgans.
