The Q_(K)(p)-Teichmüller space is introduced and studied in this paper.Various characterizations of the Q_(K)(p)-Teichmüller space and the Q_(K,0)(p)-Teichmüller space are given.Their Schwarzian derivat...The Q_(K)(p)-Teichmüller space is introduced and studied in this paper.Various characterizations of the Q_(K)(p)-Teichmüller space and the Q_(K,0)(p)-Teichmüller space are given.Their Schwarzian derivative model and pre-logarithmic derivative model are also discussed.展开更多
Selenium nanoparticles(SeNPs)have been demonstrated potential for use in diseases associated with oxidative stress.Functionalized SeNPs with lower toxicity and higher biocompatibility could bring better therapeutic ac...Selenium nanoparticles(SeNPs)have been demonstrated potential for use in diseases associated with oxidative stress.Functionalized SeNPs with lower toxicity and higher biocompatibility could bring better therapeutic activity and clinical application value.Herein,this work was conducted to investigate the protective effect of Pleurotus tuber-regium polysaccharide-protein complex funtionnalized SeNPs(PTR-SeNPs)against acetaminophen(APAP)-induced oxidative injure in HepG2 cells and C57BL/6J mouse liver.Further elucidation of the underlying molecular mechanism,in particular their modulation of Nrf2 signaling pathway was also performed.The results showed that PTR-SeNPs could significantly ameliorate APAP-induced oxidative injury as evidenced by a range of biochemical analysis,histopathological examination and immunoblotting study.PTR-SeNPs could hosphorylate and activate PKCδ,depress Keap1,and increase nuclear accumulation of Nrf2,resulting in upregulation of GCLC,GCLM,HO-1 and NQO-1 expression.Besides,PTR-SeNPs suppressed the biotransformation of APAP to generate intracellular ROS through CYP 2E1 inhibition,restoring the mitochondrial morphology.Furthermore,the protective effect of PTR-SeNPs against APAP induced hepatotoxicity was weakened as Nrf2 was depleted in vivo,indicating the pivotal role of Nrf2 signaling pathway in PTR-SeNPs mediated hepatoprotective efficacy.Being a potential hepatic protectant,PTR-SeNPs could serve as a new source of selenium supplement for health-promoting and biomedical applications.展开更多
The term"student learning outcomes"refers to the knowledge, skills, and abilitiesthat students achieve during a course, and is typically assessed based on student evaluations conducted at the end of the seme...The term"student learning outcomes"refers to the knowledge, skills, and abilitiesthat students achieve during a course, and is typically assessed based on student evaluations conducted at the end of the semester. Previous studies in this area have investigated the effects of instructional quality and academic demands separately and have been limited primarily to examining findings using student samples fromthe United States. With Japanese college students' perceptions of self-improvementin English language courses as the dependent variable, the present study directly tests the hypothesis that students who perceive instructional quality to be higher, andcourse demands to be greater, also estimate higher levels of self-improvement in English language skills. The analysis provides strong support for this hypothesis.Higher ratings of instruction and academic demands have already beenshown to increase levels of student learning(Greimel-Fuhrmann and Geyer 2003;Nois and Hudson 2006; Mc Fadden and Dart 1992). The present study is the first toprovide direct evidence of the relative importance of student evaluations ofinstructional quality and academic demands as predictors of student learning and thefirst ever to do so with a sample of Japanese college students enrolled in a required English as a foreign language course. Our hypothesis is that Japanese students whoperceive instructional quality to be higher, and course demands to be greater,estimate higher levels of self-improvement in English language skills. Thus we test Japanese students' attitudes toward instructional quality and course demands asindependent variables predicting their perceptions of self-improvement in English language courses. The research focuses on Japanese students' improvement in English language skills because English education in Japan is an arena in which thedebate over limited English proficiency rages on, and because other research suggests reconsideration of English education in light of the demands of the rapidly expanding global era(Amaki 2008).展开更多
To ensure the success of the e-learning initiatives,OUM has developed its own e-learning management system,known as myLMS.Since its introduction,many modifications and improvements have been introduced to increase its...To ensure the success of the e-learning initiatives,OUM has developed its own e-learning management system,known as myLMS.Since its introduction,many modifications and improvements have been introduced to increase its effectiveness.It is now timely that OUM take stock of its students'attitudes towards e-learning.Thus,a survey was conducted on about 1,000 students at one of OUM's own learning centres,that is,the Kelantan Regional Centrel.The study indicated that generally the teacher cohort had a somewhat neutral attitude towards e-learning.The use of e-learning was more specifically aimed at achieving short term goals of obtaining good coursework and examination grades by capitalizing on the use of the Discussion Board and Courseware.A closer examination reveals that the females prefer the Discussion Board while the males prefer the Courseware.Learners in the Engineering and English programmes had more positive attitudes towards e-learning compared to learners in the Mathematics and Science programme. Learners with CGPA＞3.0 who are categorized as high achievers are more positive towards e-learning as compared to the low achievers(CGPA＜3.0).Age difference,learners‘income per month,learners’Internet and e-learning habits were also found to be predictors of attitude towards e-learning.展开更多
基金supported by the National Natural Science Foundation of China(12271017)supported by the Natural Science Foundation of Shandong Province(ZR2022MA018)by the National Natural Science Foundation of China(12171221)。
文摘The Q_(K)(p)-Teichmüller space is introduced and studied in this paper.Various characterizations of the Q_(K)(p)-Teichmüller space and the Q_(K,0)(p)-Teichmüller space are given.Their Schwarzian derivative model and pre-logarithmic derivative model are also discussed.
基金financially supported by National Natural Science Foundation of China(81700524)Natural Science Foundation of Fujian Province(2022J01866)from Fujian Provincial Department of Science and Technology+1 种基金Key Project of Fujian University of Traditional Chinese Medicine(X2021019)Collaborative Innovation and Platform Establishment Project of Department of Science and Technology of Guangdong Province(2019A050520003)。
文摘Selenium nanoparticles(SeNPs)have been demonstrated potential for use in diseases associated with oxidative stress.Functionalized SeNPs with lower toxicity and higher biocompatibility could bring better therapeutic activity and clinical application value.Herein,this work was conducted to investigate the protective effect of Pleurotus tuber-regium polysaccharide-protein complex funtionnalized SeNPs(PTR-SeNPs)against acetaminophen(APAP)-induced oxidative injure in HepG2 cells and C57BL/6J mouse liver.Further elucidation of the underlying molecular mechanism,in particular their modulation of Nrf2 signaling pathway was also performed.The results showed that PTR-SeNPs could significantly ameliorate APAP-induced oxidative injury as evidenced by a range of biochemical analysis,histopathological examination and immunoblotting study.PTR-SeNPs could hosphorylate and activate PKCδ,depress Keap1,and increase nuclear accumulation of Nrf2,resulting in upregulation of GCLC,GCLM,HO-1 and NQO-1 expression.Besides,PTR-SeNPs suppressed the biotransformation of APAP to generate intracellular ROS through CYP 2E1 inhibition,restoring the mitochondrial morphology.Furthermore,the protective effect of PTR-SeNPs against APAP induced hepatotoxicity was weakened as Nrf2 was depleted in vivo,indicating the pivotal role of Nrf2 signaling pathway in PTR-SeNPs mediated hepatoprotective efficacy.Being a potential hepatic protectant,PTR-SeNPs could serve as a new source of selenium supplement for health-promoting and biomedical applications.
文摘The term"student learning outcomes"refers to the knowledge, skills, and abilitiesthat students achieve during a course, and is typically assessed based on student evaluations conducted at the end of the semester. Previous studies in this area have investigated the effects of instructional quality and academic demands separately and have been limited primarily to examining findings using student samples fromthe United States. With Japanese college students' perceptions of self-improvementin English language courses as the dependent variable, the present study directly tests the hypothesis that students who perceive instructional quality to be higher, andcourse demands to be greater, also estimate higher levels of self-improvement in English language skills. The analysis provides strong support for this hypothesis.Higher ratings of instruction and academic demands have already beenshown to increase levels of student learning(Greimel-Fuhrmann and Geyer 2003;Nois and Hudson 2006; Mc Fadden and Dart 1992). The present study is the first toprovide direct evidence of the relative importance of student evaluations ofinstructional quality and academic demands as predictors of student learning and thefirst ever to do so with a sample of Japanese college students enrolled in a required English as a foreign language course. Our hypothesis is that Japanese students whoperceive instructional quality to be higher, and course demands to be greater,estimate higher levels of self-improvement in English language skills. Thus we test Japanese students' attitudes toward instructional quality and course demands asindependent variables predicting their perceptions of self-improvement in English language courses. The research focuses on Japanese students' improvement in English language skills because English education in Japan is an arena in which thedebate over limited English proficiency rages on, and because other research suggests reconsideration of English education in light of the demands of the rapidly expanding global era(Amaki 2008).
文摘To ensure the success of the e-learning initiatives,OUM has developed its own e-learning management system,known as myLMS.Since its introduction,many modifications and improvements have been introduced to increase its effectiveness.It is now timely that OUM take stock of its students'attitudes towards e-learning.Thus,a survey was conducted on about 1,000 students at one of OUM's own learning centres,that is,the Kelantan Regional Centrel.The study indicated that generally the teacher cohort had a somewhat neutral attitude towards e-learning.The use of e-learning was more specifically aimed at achieving short term goals of obtaining good coursework and examination grades by capitalizing on the use of the Discussion Board and Courseware.A closer examination reveals that the females prefer the Discussion Board while the males prefer the Courseware.Learners in the Engineering and English programmes had more positive attitudes towards e-learning compared to learners in the Mathematics and Science programme. Learners with CGPA＞3.0 who are categorized as high achievers are more positive towards e-learning as compared to the low achievers(CGPA＜3.0).Age difference,learners‘income per month,learners’Internet and e-learning habits were also found to be predictors of attitude towards e-learning.
