The paramount importance and multi-purpose applications of underlying topography over forest areas have gained widespread recognition over recent decades, bringing about a variety of experimental studies on accurate u...The paramount importance and multi-purpose applications of underlying topography over forest areas have gained widespread recognition over recent decades, bringing about a variety of experimental studies on accurate underlying topography mapping. The highly spatial and temporal dynamics of forest scenarios makes traditional measuring techniques difficult to construct the precise underlying topography surface. Microwave remote sensing has been demonstrated as a promising technique to retrieve the underlying topography over large areas within a limited period, including synthetic aperture radar interferometry(InSAR), polarimetric InSAR(PolInSAR) and tomographic SAR(TomoSAR). In this paper, firstly, the main principle of digital elevation model(DEM) generation by InSAR and SAR data acquisition over forest area are introduced. Following that, several methods of underlying topography extraction based on InSAR, PolInSAR, and TomoSAR are introduced and analyzed, as well as their applications and performance are discussed afterwards. Finally, four aspects of challenge are highlighted, including SAR data acquisition, error compensation and correction, scattering model reconstruction and solution strategy of multi-source data, which needs to be further addressed for robust underlying topography estimation.展开更多
Endothelial progenitor cells(EPCs)are a circulating,bone marrow-derived cell population that participate in both vasculogenesis and vascular homeostasis.Recent studies have shown that EPCs are reduced by^50% in diabet...Endothelial progenitor cells(EPCs)are a circulating,bone marrow-derived cell population that participate in both vasculogenesis and vascular homeostasis.Recent studies have shown that EPCs are reduced by^50% in diabetes that correlates inversely with its mortality rate.In addition,EPC angiogenic functions are severely impaired in diabetes.However,the molecular and cellular mechanisms underlying EPC dysfunction are poorly understood.Our current studies have focused on in vitro and in展开更多
Introduction Hematogenous metastasis is the mainly leading cause of death in breast carcinoma patients.A better understanding of the underlying molecular and cellular mechanisms is crucial for the development of effec...Introduction Hematogenous metastasis is the mainly leading cause of death in breast carcinoma patients.A better understanding of the underlying molecular and cellular mechanisms is crucial for the development of effective treatment for metastatic breast cancer<sup>[</sup>1].It has been well established that cell adhesion and invasion is mediated by a variety of transmembrane proteins,including integrins,cadherins,selectins,and intercellular adhesion molecules.Among these adhesion molecules,the integrins and their downstream signaling pathways have been extensively studied<sup>[2]</sup>.On the other hand,the specific events determining tumor cell interactions with endo-展开更多
ailure of regeneration in injured axons accounts for permanent functional deficits after CNS injury.Thus,there has been a tremendous need to understand the mechanisms underlying regeneration failure.Previously,a predo...ailure of regeneration in injured axons accounts for permanent functional deficits after CNS injury.Thus,there has been a tremendous need to understand the mechanisms underlying regeneration failure.Previously,a predominant hypothesis held that extrinsic inhibitory factors in the adult CNS environment prevent injured axons from re-growth.However,blocking these inhibitory activities genetically led to little or no axon regeneration in vivo,suggesting that removing inhibitory activities alone is展开更多
基金Projects(41820104005,41531068,41842059,41904004)supported by the National Natural Science Foundation of China。
文摘The paramount importance and multi-purpose applications of underlying topography over forest areas have gained widespread recognition over recent decades, bringing about a variety of experimental studies on accurate underlying topography mapping. The highly spatial and temporal dynamics of forest scenarios makes traditional measuring techniques difficult to construct the precise underlying topography surface. Microwave remote sensing has been demonstrated as a promising technique to retrieve the underlying topography over large areas within a limited period, including synthetic aperture radar interferometry(InSAR), polarimetric InSAR(PolInSAR) and tomographic SAR(TomoSAR). In this paper, firstly, the main principle of digital elevation model(DEM) generation by InSAR and SAR data acquisition over forest area are introduced. Following that, several methods of underlying topography extraction based on InSAR, PolInSAR, and TomoSAR are introduced and analyzed, as well as their applications and performance are discussed afterwards. Finally, four aspects of challenge are highlighted, including SAR data acquisition, error compensation and correction, scattering model reconstruction and solution strategy of multi-source data, which needs to be further addressed for robust underlying topography estimation.
基金Supported by Grants from NIH R01GM077352,VA Merit Award I01RX000244,AHA GIA0855601G,ADA Research Award7-08-RA-23NSFC Overseas Collaborative Grant#30728021
文摘Endothelial progenitor cells(EPCs)are a circulating,bone marrow-derived cell population that participate in both vasculogenesis and vascular homeostasis.Recent studies have shown that EPCs are reduced by^50% in diabetes that correlates inversely with its mortality rate.In addition,EPC angiogenic functions are severely impaired in diabetes.However,the molecular and cellular mechanisms underlying EPC dysfunction are poorly understood.Our current studies have focused on in vitro and in
基金The financial supports provided,in whole or in part,by the National Natural Science Foundation of China(11272083)the New Century Excellent Talents Program in Chinese Universities(NCET09-0263)
文摘Introduction Hematogenous metastasis is the mainly leading cause of death in breast carcinoma patients.A better understanding of the underlying molecular and cellular mechanisms is crucial for the development of effective treatment for metastatic breast cancer<sup>[</sup>1].It has been well established that cell adhesion and invasion is mediated by a variety of transmembrane proteins,including integrins,cadherins,selectins,and intercellular adhesion molecules.Among these adhesion molecules,the integrins and their downstream signaling pathways have been extensively studied<sup>[2]</sup>.On the other hand,the specific events determining tumor cell interactions with endo-
文摘ailure of regeneration in injured axons accounts for permanent functional deficits after CNS injury.Thus,there has been a tremendous need to understand the mechanisms underlying regeneration failure.Previously,a predominant hypothesis held that extrinsic inhibitory factors in the adult CNS environment prevent injured axons from re-growth.However,blocking these inhibitory activities genetically led to little or no axon regeneration in vivo,suggesting that removing inhibitory activities alone is
