UBE2O is a distinctive ubiquitin-conjugating enzyme characterized by its large size(1292 residues)and dual E2/E3 enzymatic activities,enabling diverse ubiquitylation types.Unlike typical E2 enzymes(150~200 residues),U...UBE2O is a distinctive ubiquitin-conjugating enzyme characterized by its large size(1292 residues)and dual E2/E3 enzymatic activities,enabling diverse ubiquitylation types.Unlike typical E2 enzymes(150~200 residues),UBE2O’s multifunctionality allows it to regulate substrate degradation,subcellular localization,and functional modulation.Emerging studies highlight its critical roles in protein quality control,erythroid differentiation,metabolic regulation,and maintenance of circadian rhythm.Dysregulation of UBE2O is implicated in various diseases,including cancers,neurodegenerative disorders,and metabolic diseases.This review extensively discusses the unique structural features,diverse biological functions,and pathological roles of UBE2O,as well as its therapeutic potential for associated diseases.展开更多
以质膜 Ca2 +通道阻断剂 L a Cl3和钙调素 (Ca M)拮抗剂氯丙嗪 (CPZ)对水稻幼苗预处理以阻碍 Ca2 +· Ca M信使传导后 ,研究了盐胁迫下 ,稻苗保护酶活性的变化。结果表明 :0 .15 mol/ L Na Cl胁迫下 ,L a Cl3和 CPZ预处理显著加剧...以质膜 Ca2 +通道阻断剂 L a Cl3和钙调素 (Ca M)拮抗剂氯丙嗪 (CPZ)对水稻幼苗预处理以阻碍 Ca2 +· Ca M信使传导后 ,研究了盐胁迫下 ,稻苗保护酶活性的变化。结果表明 :0 .15 mol/ L Na Cl胁迫下 ,L a Cl3和 CPZ预处理显著加剧稻苗过氧化氢酶 (CAT)活性和抗坏血酸过氧化物酶 (APX)活性下降 ;对谷胱甘肽还原酶 (GR)活性则无明显影响 ;而超氧化物岐化酶 (SOD)和过氧化物酶 (POD)活性前期无明显变化 ,仅在胁迫后期明显下降。盐胁迫下 ,L a Cl3和 CPZ预处理加剧 SOD、 CAT和 APX活性下降与加剧稻苗 MDA含量积累呈显著或极显著正相关。这暗示 Ca2 + · Ca展开更多
基金Supported by Special Projects in Key Areas for Guangdong Provincial Colleges and Universities (No.2021ZDZX2009)Guangzhou Medical University Discipline Construction Funds (Basic Medicine)(No.JCXKJS2022A05)。
文摘UBE2O is a distinctive ubiquitin-conjugating enzyme characterized by its large size(1292 residues)and dual E2/E3 enzymatic activities,enabling diverse ubiquitylation types.Unlike typical E2 enzymes(150~200 residues),UBE2O’s multifunctionality allows it to regulate substrate degradation,subcellular localization,and functional modulation.Emerging studies highlight its critical roles in protein quality control,erythroid differentiation,metabolic regulation,and maintenance of circadian rhythm.Dysregulation of UBE2O is implicated in various diseases,including cancers,neurodegenerative disorders,and metabolic diseases.This review extensively discusses the unique structural features,diverse biological functions,and pathological roles of UBE2O,as well as its therapeutic potential for associated diseases.
文摘以质膜 Ca2 +通道阻断剂 L a Cl3和钙调素 (Ca M)拮抗剂氯丙嗪 (CPZ)对水稻幼苗预处理以阻碍 Ca2 +· Ca M信使传导后 ,研究了盐胁迫下 ,稻苗保护酶活性的变化。结果表明 :0 .15 mol/ L Na Cl胁迫下 ,L a Cl3和 CPZ预处理显著加剧稻苗过氧化氢酶 (CAT)活性和抗坏血酸过氧化物酶 (APX)活性下降 ;对谷胱甘肽还原酶 (GR)活性则无明显影响 ;而超氧化物岐化酶 (SOD)和过氧化物酶 (POD)活性前期无明显变化 ,仅在胁迫后期明显下降。盐胁迫下 ,L a Cl3和 CPZ预处理加剧 SOD、 CAT和 APX活性下降与加剧稻苗 MDA含量积累呈显著或极显著正相关。这暗示 Ca2 + · Ca
