A Series of mono and di-nuclear Zn Ni complexes with 5 - chlorosalicylaldehyde -ethylenediamine Schiff base have been synthesized. Theirs compositions and structures were characterized by the elemental analysis.UV.IR ...A Series of mono and di-nuclear Zn Ni complexes with 5 - chlorosalicylaldehyde -ethylenediamine Schiff base have been synthesized. Theirs compositions and structures were characterized by the elemental analysis.UV.IR spectra and 1H NMR. The Dismutation to O2 free radical has also been investigated.展开更多
Nickel(Ⅱ),Copper(Ⅱ),Zinc(Ⅱ),and Cadmium(Ⅱ)complexes derived from schiff base of N-Salicylidenelysine acid were synthesized.These complexes were characterized by elemental analysis,conductivity measurement,IR and e...Nickel(Ⅱ),Copper(Ⅱ),Zinc(Ⅱ),and Cadmium(Ⅱ)complexes derived from schiff base of N-Salicylidenelysine acid were synthesized.These complexes were characterized by elemental analysis,conductivity measurement,IR and electronic spectra.The anti-bacterium activity of the complexes were tested.展开更多
A Schiff base ligand 4-[indol-3-yl]-but-3-en-2-one benzoyl hydrazone (HL), and its four transition metal complexes (ML2,M=Cu(, Ni(, Zn( and Co() have been prepared and characterized by means of elemental analysis, EI-...A Schiff base ligand 4-[indol-3-yl]-but-3-en-2-one benzoyl hydrazone (HL), and its four transition metal complexes (ML2,M=Cu(, Ni(, Zn( and Co() have been prepared and characterized by means of elemental analysis, EI-MS, molar conductivity, IR, UV-Vis and 1H NMR. The results showed that HL as a bidentate ligand coordinated with transition metal ions to form four-coordination complexes. The antibacterial activity was studied by using the filter scraps diffusion method, and the results indicated that the ligand and the complexes had a low bacteriostatic activity against S. Aureu, P. Aeruginosa and E. Coli. The low in vitro antitumor activity of the title complexes was also observed by using MTT method against KB, A2780, Bel7402 and HELF.展开更多
Two of new Schiff bases,3-nitrobenzaldehyde salicyloyl hydrazone(C14H11N3O4),vanillic salicyloyl hydrazone(C15H14N2O4),were synthesized and characterized by the melting point,elemental analysis,UV,IR,MS and （）1H NMR...Two of new Schiff bases,3-nitrobenzaldehyde salicyloyl hydrazone(C14H11N3O4),vanillic salicyloyl hydrazone(C15H14N2O4),were synthesized and characterized by the melting point,elemental analysis,UV,IR,MS and （）1H NMR.The results,based on indexing the cell parameters of XRD,showed that they belonged to orthorhombic system.And the result peoved that the Schiff bases had selective antibacterial property.展开更多
Four Schiff bases derived from o vanillin and amino acids have been synthesized and characterized by elemental analysis and IR. The conformations of four Schiff bases have been studied using molecular dynamics and qua...Four Schiff bases derived from o vanillin and amino acids have been synthesized and characterized by elemental analysis and IR. The conformations of four Schiff bases have been studied using molecular dynamics and quantum chemistry analysis approaches. The results revealed that the trans CN with R configuration of the title compounds are more stable than their S configuration and there was a negative charge hole in the Schiff base, which shows the high possibility of forming stable complexe because metal ion is easy to enter this negative charge hole.展开更多
The novel dinuclear copper(Ⅱ) complex with with N (2,4 dihydroxybenzalidene) o aminobenzoic acid ligand, [Cu(C14H9NO4)]2· 2H2O, has been synthesized and characterized by elemental analysis, IR, UV Vis and therma...The novel dinuclear copper(Ⅱ) complex with with N (2,4 dihydroxybenzalidene) o aminobenzoic acid ligand, [Cu(C14H9NO4)]2· 2H2O, has been synthesized and characterized by elemental analysis, IR, UV Vis and thermal analysis. Its crystal structure was determined by single crystal X ray diffraction techniques. The crystal belongs to monoclinic with space group P21/c. The cell parameters are: a=0.82510(11)nm, b=0.68870(9)nm, c=2.3007(3)nm, β =100.847(2)° , V=1.2840(3)nm3, Z=2, Dc=1.742Mg· m- 3, μ (MoKα )=1.723mm- 1, F(000)=684. The structure was refined to final R1=0.0267, wR2=0.0735. The complex molecule structure has dinuclear centrosymmetric dimeric structure in which a planar Cu2O2 core features. The ligand N (2,4 dihydroxybenzalidene) o aminobenzoic acid dianion is μ 2 tridentate, chelating one copper? ion via one nitrogen, one hydroxy oxygen atom and one carboxylate oxygen atom, and the hydroxy oxygen atom simultaneously coordinates to the other copper? ion of the dimer. In the structure the copper? ion rendered four coordination in a distorted square planar geometry structure. CCDC: 212695.展开更多
One novel complex of （）99mTc-salicylidene-tyrosine Schiff base was designed and synthesized, and its biodistribution was investigated. The theoretical simulation revealed that the cis- and trans-（isomers） might co...One novel complex of （）99mTc-salicylidene-tyrosine Schiff base was designed and synthesized, and its biodistribution was investigated. The theoretical simulation revealed that the cis- and trans-（isomers） might co-exist in aqueous solution. A yield higher than 90% under the optimal condition of synthesis was obtained. Good water-solubility was demonstrated. Very little uptakes in muscle, brain, heart and S-180 sarcoma, as well as very rapid blood clearance were revealed in mice. Good accumulation in bone was shown. At 1 h postinjection the bone uptake was 10.9%ID/g. At 3 and 5 h postinjection, bone-to-muscle ratios were 19.0 and 9.3, and bone-to-blood ratios were 31.6 and 28.9, respectively. The result indicates a bone imaging potency of the complex.展开更多
文摘A Series of mono and di-nuclear Zn Ni complexes with 5 - chlorosalicylaldehyde -ethylenediamine Schiff base have been synthesized. Theirs compositions and structures were characterized by the elemental analysis.UV.IR spectra and 1H NMR. The Dismutation to O2 free radical has also been investigated.
文摘Nickel(Ⅱ),Copper(Ⅱ),Zinc(Ⅱ),and Cadmium(Ⅱ)complexes derived from schiff base of N-Salicylidenelysine acid were synthesized.These complexes were characterized by elemental analysis,conductivity measurement,IR and electronic spectra.The anti-bacterium activity of the complexes were tested.
文摘A Schiff base ligand 4-[indol-3-yl]-but-3-en-2-one benzoyl hydrazone (HL), and its four transition metal complexes (ML2,M=Cu(, Ni(, Zn( and Co() have been prepared and characterized by means of elemental analysis, EI-MS, molar conductivity, IR, UV-Vis and 1H NMR. The results showed that HL as a bidentate ligand coordinated with transition metal ions to form four-coordination complexes. The antibacterial activity was studied by using the filter scraps diffusion method, and the results indicated that the ligand and the complexes had a low bacteriostatic activity against S. Aureu, P. Aeruginosa and E. Coli. The low in vitro antitumor activity of the title complexes was also observed by using MTT method against KB, A2780, Bel7402 and HELF.
文摘Two of new Schiff bases,3-nitrobenzaldehyde salicyloyl hydrazone(C14H11N3O4),vanillic salicyloyl hydrazone(C15H14N2O4),were synthesized and characterized by the melting point,elemental analysis,UV,IR,MS and （）1H NMR.The results,based on indexing the cell parameters of XRD,showed that they belonged to orthorhombic system.And the result peoved that the Schiff bases had selective antibacterial property.
文摘Four Schiff bases derived from o vanillin and amino acids have been synthesized and characterized by elemental analysis and IR. The conformations of four Schiff bases have been studied using molecular dynamics and quantum chemistry analysis approaches. The results revealed that the trans CN with R configuration of the title compounds are more stable than their S configuration and there was a negative charge hole in the Schiff base, which shows the high possibility of forming stable complexe because metal ion is easy to enter this negative charge hole.
文摘The novel dinuclear copper(Ⅱ) complex with with N (2,4 dihydroxybenzalidene) o aminobenzoic acid ligand, [Cu(C14H9NO4)]2· 2H2O, has been synthesized and characterized by elemental analysis, IR, UV Vis and thermal analysis. Its crystal structure was determined by single crystal X ray diffraction techniques. The crystal belongs to monoclinic with space group P21/c. The cell parameters are: a=0.82510(11)nm, b=0.68870(9)nm, c=2.3007(3)nm, β =100.847(2)° , V=1.2840(3)nm3, Z=2, Dc=1.742Mg· m- 3, μ (MoKα )=1.723mm- 1, F(000)=684. The structure was refined to final R1=0.0267, wR2=0.0735. The complex molecule structure has dinuclear centrosymmetric dimeric structure in which a planar Cu2O2 core features. The ligand N (2,4 dihydroxybenzalidene) o aminobenzoic acid dianion is μ 2 tridentate, chelating one copper? ion via one nitrogen, one hydroxy oxygen atom and one carboxylate oxygen atom, and the hydroxy oxygen atom simultaneously coordinates to the other copper? ion of the dimer. In the structure the copper? ion rendered four coordination in a distorted square planar geometry structure. CCDC: 212695.
文摘One novel complex of （）99mTc-salicylidene-tyrosine Schiff base was designed and synthesized, and its biodistribution was investigated. The theoretical simulation revealed that the cis- and trans-（isomers） might co-exist in aqueous solution. A yield higher than 90% under the optimal condition of synthesis was obtained. Good water-solubility was demonstrated. Very little uptakes in muscle, brain, heart and S-180 sarcoma, as well as very rapid blood clearance were revealed in mice. Good accumulation in bone was shown. At 1 h postinjection the bone uptake was 10.9%ID/g. At 3 and 5 h postinjection, bone-to-muscle ratios were 19.0 and 9.3, and bone-to-blood ratios were 31.6 and 28.9, respectively. The result indicates a bone imaging potency of the complex.
