Model-based system-of-systems(SOS)engineering(MBSoSE)is becoming a promising solution for the design of SoS with increasing complexity.However,bridging the models from the design phase to the simulation phase poses si...Model-based system-of-systems(SOS)engineering(MBSoSE)is becoming a promising solution for the design of SoS with increasing complexity.However,bridging the models from the design phase to the simulation phase poses significant challenges and requires an integrated approach.In this study,a unified requirement modeling approach is proposed based on unified architecture framework(UAF).Theoretical models are proposed which compose formalized descriptions from both topdown and bottom-up perspectives.Based on the description,the UAF profile is proposed to represent the SoS mission and constituent systems(CS)goal.Moreover,the agent-based simulation information is also described based on the overview,design concepts,and details(ODD)protocol as the complement part of the SoS profile,which can be transformed into different simulation platforms based on the eXtensible markup language(XML)technology and model-to-text method.In this way,the design of the SoS is simulated automatically in the early design stage.Finally,the method is implemented and an example is given to illustrate the whole process.展开更多
Space robots possess unique distinguishing features unlike general robots on earth, due to the particular environments in space. The developing of various practical space robots promoting the improvement of space scie...Space robots possess unique distinguishing features unlike general robots on earth, due to the particular environments in space. The developing of various practical space robots promoting the improvement of space science and technology is a complex man-machine-environment engineering problem. This paper analyses from the systems engineering viewpoint the space robot system in the scope of the architecture of robotics discipline, space environment characteristics, man-machine-environment system of space robots, the general methodology of project systems engineering and the process of space robot systems engineering.展开更多
The definitions, methodology, applications, and perspectives of process system engineering are discussed from a strategic point of view. The focal points in future development of process systems engineering are to bre...The definitions, methodology, applications, and perspectives of process system engineering are discussed from a strategic point of view. The focal points in future development of process systems engineering are to break through in methodology, to expand application fields, and to develop a new generation of process simulation systems.展开更多
The immune checkpoint blockade has revolutionized cancer treatment.However,not all cancer types are susceptible to this therapy.Even in melanoma,one of the best scenario,about half of the patients do not respond to im...The immune checkpoint blockade has revolutionized cancer treatment.However,not all cancer types are susceptible to this therapy.Even in melanoma,one of the best scenario,about half of the patients do not respond to immune checkpoint blockade.Since CD8+T cell is the main driving force behind cancer elimination,then having a complete and competent T cell repertoire to cover all possible cancer antigens expressed by cancer cells should be a determining factor to the success of this therapy.Conversely,if there are'holes'in patients’T cell repertoire and/or'weak spots'manifested as functional dysregulation or exhaustion on T cells specific to a set of cancer antigens that dominantly expressed by cancer cells,cancer immune escape is inevitable.However,these two types of cancer immune escape might need different treatment strategies:the first group with'holes'in the T cell repertoire,whether the'holes'are taking on a form of missing T cells to cover these cancer antigens or missing high-affinity TCRs that are known to be more sensitive to antigen stimulation,would be benefited from TCR re-directed adoptive cell transfer(ACT)therapy;the other group with T cell repertoire'weak spots'would be benefited from immune checkpoint blockade alone or in combination with additional stimulatory factors such as cytokines and peptide vaccine.In the past decade,we have developed several tools to profile the T cell repertoire from T cell receptor diversity to T cell receptor affinity to high-throughput linking antigen specificity to single T cell receptor sequences in large scale.In this talk,I will first introduce these tools and then give examples on how we use them to answer some of the fundamental questions in systems immunology with a focus on cancer immunology,which in turn help us design new therapeutics immune engineering.展开更多
This article provides an overview of the architecture of system science developed by Qian Xuesen, with a particular stress laid upon the methodology and theoretical basis of systems engineering. The latter refers main...This article provides an overview of the architecture of system science developed by Qian Xuesen, with a particular stress laid upon the methodology and theoretical basis of systems engineering. The latter refers mainly to the establishment of systematology. Presented here is an introduction to some conclusions on the object, content and method of systematology study that have been reached by a seminar under the personal direction of Qian Xuesen.展开更多
The Journal of Systems Engineering and Electronics is a comprehensive academic periodical jointly sponsored by Defense Technology Academy of China Aerospace Science ＆ Industry Corporation, Chinese Society of Astronau...The Journal of Systems Engineering and Electronics is a comprehensive academic periodical jointly sponsored by Defense Technology Academy of China Aerospace Science ＆ Industry Corporation, Chinese Society of Astronautics, System Engineering Society of China, and Chinese Association for System Simulation. It started publication in 1990, and now is published bimonthly.展开更多
This journal is devoted to the advancement of the science and technology of systems engineering and electronics through the dissemination of original archival research papers disclosing significant technical knowledge...This journal is devoted to the advancement of the science and technology of systems engineering and electronics through the dissemination of original archival research papers disclosing significant technical knowledge, exploratory developments, and applications in astronautics, aeronautics, and related fields. In addition, the journal also publishes survey, expository and tutorial papers. Both theory and applications will be equally emphasized. The scope of the Journal is broad and multi-disciplinary. It covers systems science, modelling and simulation, aero-space system analysis, vehicle control, communication, radar, optoelectronic detector, information acquisition and processing, target and environmental features, remote sensing,展开更多
The Journal of Systems Engineering and Electronics(English Edition) is a comprehensive academic periodical jointly sponsored by the Second Academy of China Aerospace Science and Industry Corporation, the Chinese Socie...The Journal of Systems Engineering and Electronics(English Edition) is a comprehensive academic periodical jointly sponsored by the Second Academy of China Aerospace Science and Industry Corporation, the Chinese Society of Astronautics,the Systems Engineering Society of China,and the Chinese Association for System Simulation.It started publication in 1990,and now appears six times a year, distributed at home and abroad.展开更多
The Journal of Systems Engineering and Electronics is a comprehensive academic periodical jointly sponsored by Defense Technology Academy of China Aerospace Science ＆ Industry Corporation, Chinese Society of Astronau...The Journal of Systems Engineering and Electronics is a comprehensive academic periodical jointly sponsored by Defense Technology Academy of China Aerospace Science ＆ Industry Corporation, Chinese Society of Astronautics, System Engineering Society of China, and Chinese Association for System Simulation. It started publication in 1990, and now is published bimonthly.展开更多
The Journal of Systems Engineering and Electronics (English Edition) is a comprehensive academic periodical jointly sponsored by the Second Academy of China Aerospace Science and Industry Corpo- ration,the Chinese Soc...The Journal of Systems Engineering and Electronics (English Edition) is a comprehensive academic periodical jointly sponsored by the Second Academy of China Aerospace Science and Industry Corpo- ration,the Chinese Society of Astronautics,the Systems Engineering Society of China and the Chinese Association for System Simulation.It started publication in 1990,and now appears six times a year, distributed at home and abroad.展开更多
The Journal of Systems Engineering and Electronics （English Edition） is a comprehensive academic periodical jointly sponsored by the Second Academy of China Aerospace Science and Industry Corporation, the Chinese So...The Journal of Systems Engineering and Electronics （English Edition） is a comprehensive academic periodical jointly sponsored by the Second Academy of China Aerospace Science and Industry Corporation, the Chinese Society of Astronautics, the Systems Engineering Society of China, and the Chinese Association for System Simulation. It started publication in 1990, and now appears six times a year, distributed at home and abroad.展开更多
Control systems contribute to every aspect of modem society.In our life control systems exist in almost everywhere such as toasters,VCRs and smart phones.In science and technology,control systems already have widespre...Control systems contribute to every aspect of modem society.In our life control systems exist in almost everywhere such as toasters,VCRs and smart phones.In science and technology,control systems already have widespread applications,for example,steering ships,guiding missiles and driving driverless cars in the near future.In all the control systems,systems are the key platform where control should be put into.It is at the system level that control shows its values.Extracting and formulating展开更多
The Journal of Systems Engineering and Electronics （English Edition） is a comprehensive academic periodical jointly sponsored by the Second Academy of China Aerospace Science and Industry Corporation, the Chinese So...The Journal of Systems Engineering and Electronics （English Edition） is a comprehensive academic periodical jointly sponsored by the Second Academy of China Aerospace Science and Industry Corporation, the Chinese Society of Astronautics, the Systems Engineering Society of China and the Chinese Association for System Simulation. It started publication in 1990, and now appears six times a year, distributed at home and abroad.展开更多
基金Fifth Electronic Research Institute of the Ministry of Industry and Information Technology(HK07202200877)Pre-research Project on Civil Aerospace Technologies of CNSA(D020101)+2 种基金Zhejiang Provincial Science and Technology Plan Project(2022C01052)Frontier Scientific Research Program of Deep Space Exploration Laboratory(2022-QYKYJHHXYF-018,2022-QYKYJH-GCXD-001)Zhiyuan Laboratory(ZYL2024001)。
文摘Model-based system-of-systems(SOS)engineering(MBSoSE)is becoming a promising solution for the design of SoS with increasing complexity.However,bridging the models from the design phase to the simulation phase poses significant challenges and requires an integrated approach.In this study,a unified requirement modeling approach is proposed based on unified architecture framework(UAF).Theoretical models are proposed which compose formalized descriptions from both topdown and bottom-up perspectives.Based on the description,the UAF profile is proposed to represent the SoS mission and constituent systems(CS)goal.Moreover,the agent-based simulation information is also described based on the overview,design concepts,and details(ODD)protocol as the complement part of the SoS profile,which can be transformed into different simulation platforms based on the eXtensible markup language(XML)technology and model-to-text method.In this way,the design of the SoS is simulated automatically in the early design stage.Finally,the method is implemented and an example is given to illustrate the whole process.
文摘Space robots possess unique distinguishing features unlike general robots on earth, due to the particular environments in space. The developing of various practical space robots promoting the improvement of space science and technology is a complex man-machine-environment engineering problem. This paper analyses from the systems engineering viewpoint the space robot system in the scope of the architecture of robotics discipline, space environment characteristics, man-machine-environment system of space robots, the general methodology of project systems engineering and the process of space robot systems engineering.
文摘The definitions, methodology, applications, and perspectives of process system engineering are discussed from a strategic point of view. The focal points in future development of process systems engineering are to break through in methodology, to expand application fields, and to develop a new generation of process simulation systems.
文摘The immune checkpoint blockade has revolutionized cancer treatment.However,not all cancer types are susceptible to this therapy.Even in melanoma,one of the best scenario,about half of the patients do not respond to immune checkpoint blockade.Since CD8+T cell is the main driving force behind cancer elimination,then having a complete and competent T cell repertoire to cover all possible cancer antigens expressed by cancer cells should be a determining factor to the success of this therapy.Conversely,if there are'holes'in patients’T cell repertoire and/or'weak spots'manifested as functional dysregulation or exhaustion on T cells specific to a set of cancer antigens that dominantly expressed by cancer cells,cancer immune escape is inevitable.However,these two types of cancer immune escape might need different treatment strategies:the first group with'holes'in the T cell repertoire,whether the'holes'are taking on a form of missing T cells to cover these cancer antigens or missing high-affinity TCRs that are known to be more sensitive to antigen stimulation,would be benefited from TCR re-directed adoptive cell transfer(ACT)therapy;the other group with T cell repertoire'weak spots'would be benefited from immune checkpoint blockade alone or in combination with additional stimulatory factors such as cytokines and peptide vaccine.In the past decade,we have developed several tools to profile the T cell repertoire from T cell receptor diversity to T cell receptor affinity to high-throughput linking antigen specificity to single T cell receptor sequences in large scale.In this talk,I will first introduce these tools and then give examples on how we use them to answer some of the fundamental questions in systems immunology with a focus on cancer immunology,which in turn help us design new therapeutics immune engineering.
文摘This article provides an overview of the architecture of system science developed by Qian Xuesen, with a particular stress laid upon the methodology and theoretical basis of systems engineering. The latter refers mainly to the establishment of systematology. Presented here is an introduction to some conclusions on the object, content and method of systematology study that have been reached by a seminar under the personal direction of Qian Xuesen.
文摘The Journal of Systems Engineering and Electronics is a comprehensive academic periodical jointly sponsored by Defense Technology Academy of China Aerospace Science ＆ Industry Corporation, Chinese Society of Astronautics, System Engineering Society of China, and Chinese Association for System Simulation. It started publication in 1990, and now is published bimonthly.
文摘This journal is devoted to the advancement of the science and technology of systems engineering and electronics through the dissemination of original archival research papers disclosing significant technical knowledge, exploratory developments, and applications in astronautics, aeronautics, and related fields. In addition, the journal also publishes survey, expository and tutorial papers. Both theory and applications will be equally emphasized. The scope of the Journal is broad and multi-disciplinary. It covers systems science, modelling and simulation, aero-space system analysis, vehicle control, communication, radar, optoelectronic detector, information acquisition and processing, target and environmental features, remote sensing,
文摘The Journal of Systems Engineering and Electronics(English Edition) is a comprehensive academic periodical jointly sponsored by the Second Academy of China Aerospace Science and Industry Corporation, the Chinese Society of Astronautics,the Systems Engineering Society of China,and the Chinese Association for System Simulation.It started publication in 1990,and now appears six times a year, distributed at home and abroad.
文摘The Journal of Systems Engineering and Electronics is a comprehensive academic periodical jointly sponsored by Defense Technology Academy of China Aerospace Science ＆ Industry Corporation, Chinese Society of Astronautics, System Engineering Society of China, and Chinese Association for System Simulation. It started publication in 1990, and now is published bimonthly.
文摘The Journal of Systems Engineering and Electronics (English Edition) is a comprehensive academic periodical jointly sponsored by the Second Academy of China Aerospace Science and Industry Corpo- ration,the Chinese Society of Astronautics,the Systems Engineering Society of China and the Chinese Association for System Simulation.It started publication in 1990,and now appears six times a year, distributed at home and abroad.
文摘The Journal of Systems Engineering and Electronics （English Edition） is a comprehensive academic periodical jointly sponsored by the Second Academy of China Aerospace Science and Industry Corporation, the Chinese Society of Astronautics, the Systems Engineering Society of China, and the Chinese Association for System Simulation. It started publication in 1990, and now appears six times a year, distributed at home and abroad.
文摘Control systems contribute to every aspect of modem society.In our life control systems exist in almost everywhere such as toasters,VCRs and smart phones.In science and technology,control systems already have widespread applications,for example,steering ships,guiding missiles and driving driverless cars in the near future.In all the control systems,systems are the key platform where control should be put into.It is at the system level that control shows its values.Extracting and formulating
文摘The Journal of Systems Engineering and Electronics （English Edition） is a comprehensive academic periodical jointly sponsored by the Second Academy of China Aerospace Science and Industry Corporation, the Chinese Society of Astronautics, the Systems Engineering Society of China and the Chinese Association for System Simulation. It started publication in 1990, and now appears six times a year, distributed at home and abroad.
