Through computer screening of Genbank and experimental analysis a novel snoRNA, termed Z25, was first identified from mammals. Z25 snoRNA is 69 nucleotide in length, possessing typical boxC/D and terminal repeat seque...Through computer screening of Genbank and experimental analysis a novel snoRNA, termed Z25, was first identified from mammals. Z25 snoRNA is 69 nucleotide in length, possessing typical boxC/D and terminal repeat sequence, a 11 nt long sequence complementarity to 18S rRNA implies that Z25 snoRNA is a 2′ O ribose methylation guide at A1678 (human coordinate) of 18S rRNA. Z25 snoRNA is encoded by the fifth intron of human, mouse and rat nucleolin genes that have been found as the host genes for U20 and U23 snoRNA.展开更多
文摘Through computer screening of Genbank and experimental analysis a novel snoRNA, termed Z25, was first identified from mammals. Z25 snoRNA is 69 nucleotide in length, possessing typical boxC/D and terminal repeat sequence, a 11 nt long sequence complementarity to 18S rRNA implies that Z25 snoRNA is a 2′ O ribose methylation guide at A1678 (human coordinate) of 18S rRNA. Z25 snoRNA is encoded by the fifth intron of human, mouse and rat nucleolin genes that have been found as the host genes for U20 and U23 snoRNA.
